PTSDgene database

Study Report

Study Information
Basic Info
Reference
Citation Grabe, H. J., et al. (2009). "Serotonin transporter gene (SLC6A4) promoter polymorphisms and the susceptibility to posttraumatic stress disorder in the general population." Am J Psychiatry 166(8): 926-933.
Phenotype PTSD diagnosis, PTSD category B symptom score, PTSD category C symptom score, PTSD category D symptom score
Trauma Various
Study Design Cross-sectional study
Study Type Candidate gene association study, Gene-environment interaction study
Sample Size 3045 samples
SNP/Marker Size 1 Variant
Predominant Ethnicity Caucasian
Population Adult German residents
Gender 1571 females, 1474 males
Age Subject without traumatic experience: mean age= 50 years, SD=13.3, subjecs with at least one traumatic experience: mean age= 57.6 years, SD=15.6.

Detail Info

Genetic result reported by this study
Normal genetic result reported by this study (count: 4)
Marker Phenotype Related Gene Statistical Values Author Comments Marker's Category
5-HTTLPR PTSD category D symptom score SLC6A4 Genotypes: P-value>=0.05 No associations were established between the 5-HTTLPR genoty...... No associations were established between the 5-HTTLPR genotypes and criteria B, C,or D. More... Non-significant
5-HTTLPR PTSD category C symptom score SLC6A4 Genotypes: P-value>=0.05 No associations were established between the 5-HTTLPR genoty...... No associations were established between the 5-HTTLPR genotypes and criteria B, C,or D. More... Non-significant
5-HTTLPR PTSD category B symptom score SLC6A4 Genotypes: P-value>=0.05 No associations were established between the 5-HTTLPR genoty...... No associations were established between the 5-HTTLPR genotypes and criteria B, C,or D. More... Non-significant
5-HTTLPR PTSD diagnosis SLC6A4 Genotypes: unadjusted: P-value=0.04, age and gender adjusted: P-value=0.05. Number of LA alleles: unadjusted: P-value=0.01, age and gender adjusted: P-value=0.01. All associations between the LA/LA genotype and PTSD (both c...... All associations between the LA/LA genotype and PTSD (both crude and adjusted) were statistically significant. More... Significant

Gene * Environment result reported by this study (count: 4)
Marker Phenotype Related Gene Environment Statistical Values Author Comments Marker's Category
5-HTTLPR PTSD diagnosis SLC6A4 NTE (number of traumatic events) Three as a cutoff point for the number of traumas: RERI was 1.3 for the unadjusted model and 1.5 (95% CI=0.5-4.3, P-value<0.05) for the fully adjusted model. Four as a cutoff point for the number of traumas: RERI increased to 1.8 (95% CI=1.6-31.7, P-value<0.05). When two was used as a cutoff point for the number of traumas, no statistically significant interactions emerged. For the final model, RERI was 3.3. Statistically significant interactions was found between num...... Statistically significant interactions was found between number of traumatic events and 5-HTTLPR genotype. More... Significant
5-HTTLPR PTSD category D symptom score SLC6A4 NTE (number of traumatic events) RERI for the continuous genetic model (zero, one, or two LA alleles) was 1.2 (95% CI=0.5-2.8, P-value<0.05). Statistically significant interactions was found between num...... Statistically significant interactions was found between number of traumatic events and 5-HTTLPR genotype. More... Significant
5-HTTLPR PTSD category C symptom score SLC6A4 NTE (number of traumatic events) No detail information No statistically significant interactions emerged when perfo...... No statistically significant interactions emerged when performing the analyses for B and C criteria irrespective of the trauma threshold. More... Non-significant
5-HTTLPR PTSD category B symptom score SLC6A4 NTE (number of traumatic events) No detail information No statistically significant interactions emerged when perfo...... No statistically significant interactions emerged when performing the analyses for B and C criteria irrespective of the trauma threshold. More... Non-significant