Study Report
Study Information
Basic Info
| Reference |
Grabe, H. J.,2009 PMID: 19487392
|
| Citation |
Grabe, H. J., et al. (2009). "Serotonin transporter gene (SLC6A4) promoter polymorphisms and the susceptibility to posttraumatic stress disorder in the general population." Am J Psychiatry 166(8): 926-933. |
| Phenotype |
PTSD diagnosis, PTSD category B symptom score, PTSD category C symptom score, PTSD category D symptom score |
| Trauma |
Various |
| Study Design |
Cross-sectional study |
| Study Type |
Candidate gene association study, Gene-environment interaction study |
| Sample Size |
3045 samples |
| SNP/Marker Size |
1 Variant |
| Predominant Ethnicity |
Caucasian |
| Population |
Adult German residents |
| Gender |
1571 females, 1474 males |
| Age |
Subject without traumatic experience: mean age= 50 years, SD=13.3, subjecs with at least one traumatic experience: mean age= 57.6 years, SD=15.6. |
Detail Info
| Sample Diagnosis |
DSM-IV |
| Related Diagnostic Tools |
The Structured Clinical Interview for DSM-IV (SCID), the Mini-Mental State Examination, the Composite International Diagnostic-Screener. |
| Sample Status |
None |
| Controls Exposed |
NA |
| Replication Size |
None |
| Result Summary |
This finding suggests that there is an additive excess risk for frequent trauma in the LA/LA genotype, which was confirmed by the relative excess risk due to interaction (RERI). In allelic analysis, RERI was 3.3. Thus, the odds ratio for PTSD in LA allele carriers exposed to three or more traumas was 3.3 times higher as a result of the interaction between PTSD and the LA allele. |
| Potential Biomarker |
None |
Genetic result reported by this study
Normal genetic result reported by this study (count: 4)
| Marker |
Phenotype |
Related Gene |
Statistical Values |
Author Comments |
Marker's Category |
|
5-HTTLPR
|
PTSD category D symptom score |
SLC6A4 |
Genotypes: P-value>=0.05 |
No associations were established between the 5-HTTLPR genoty......
No associations were established between the 5-HTTLPR genotypes and criteria B, C,or D.
More...
|
Non-significant |
|
5-HTTLPR
|
PTSD category C symptom score |
SLC6A4 |
Genotypes: P-value>=0.05 |
No associations were established between the 5-HTTLPR genoty......
No associations were established between the 5-HTTLPR genotypes and criteria B, C,or D.
More...
|
Non-significant |
|
5-HTTLPR
|
PTSD category B symptom score |
SLC6A4 |
Genotypes: P-value>=0.05 |
No associations were established between the 5-HTTLPR genoty......
No associations were established between the 5-HTTLPR genotypes and criteria B, C,or D.
More...
|
Non-significant |
|
5-HTTLPR
|
PTSD diagnosis |
SLC6A4 |
Genotypes: unadjusted: P-value=0.04, age and gender adjusted: P-value=0.05. Number of LA alleles: unadjusted: P-value=0.01, age and gender adjusted: P-value=0.01. |
All associations between the LA/LA genotype and PTSD (both c......
All associations between the LA/LA genotype and PTSD (both crude and adjusted) were statistically significant.
More...
|
Significant |
Gene * Environment result reported by this study (count: 4)
| Marker |
Phenotype |
Related Gene |
Environment |
Statistical Values |
Author Comments |
Marker's Category |
|
5-HTTLPR
|
PTSD diagnosis |
SLC6A4 |
NTE (number of traumatic events) |
Three as a cutoff point for the number of traumas: RERI was 1.3 for the unadjusted model and 1.5 (95% CI=0.5-4.3, P-value<0.05) for the fully adjusted model. Four as a cutoff point for the number of traumas: RERI increased to 1.8 (95% CI=1.6-31.7, P-value<0.05). When two was used as a cutoff point for the number of traumas, no statistically significant interactions emerged. For the final model, RERI was 3.3. |
Statistically significant interactions was found between num......
Statistically significant interactions was found between number of traumatic events and 5-HTTLPR genotype.
More...
|
Significant |
|
5-HTTLPR
|
PTSD category D symptom score |
SLC6A4 |
NTE (number of traumatic events) |
RERI for the continuous genetic model (zero, one, or two LA alleles) was 1.2 (95% CI=0.5-2.8, P-value<0.05). |
Statistically significant interactions was found between num......
Statistically significant interactions was found between number of traumatic events and 5-HTTLPR genotype.
More...
|
Significant |
|
5-HTTLPR
|
PTSD category C symptom score |
SLC6A4 |
NTE (number of traumatic events) |
No detail information |
No statistically significant interactions emerged when perfo......
No statistically significant interactions emerged when performing the analyses for B and C criteria irrespective of the trauma threshold.
More...
|
Non-significant |
|
5-HTTLPR
|
PTSD category B symptom score |
SLC6A4 |
NTE (number of traumatic events) |
No detail information |
No statistically significant interactions emerged when perfo......
No statistically significant interactions emerged when performing the analyses for B and C criteria irrespective of the trauma threshold.
More...
|
Non-significant |
