SNP Report
Basic Info
| Name | rs2312236 dbSNP Ensembl | ||
|---|---|---|---|
| Location | 1:166824980 - 166824980(+) | ||
| Variant Seq | C | ||
| Ancestral Allele | C | ||
| Ref Seq | T | ||
| Minor Allele Frequence | 0.0654952 | ||
| Annotation | downstream_gene_variant | ||
| SIFT Annotation | deleterious | ||
| SIFT Variant Effect | deleterious(ENST00000354422, ENST00000456900, ENST00000338353, ENST00000435676, ENST00000441649) | ||
| PolyPhen Annotation | probably_damaging | ||
| PolyPhen Variant Effect | probably_damaging(ENST00000354422, ENST00000456900, ENST00000338353, ENST00000435676, ENST00000441649) | ||
| rSNP? | Yes Link in rVarBase | ||
| Related Regulatory Elements | Chromatin interactive region | ||
| Chromatin State | Inactive region | ||
| No. of Marker's Association Results | 1 (Positive: 0; Negative: 0; Trend: 1) | ||
| Source | Literature | ||
SNP related association results
| Reference | Phenotype | Statistical Values | Author Comments | Marker's Category |
|---|---|---|---|---|
| Nievergelt, C. M.,2015 | PTSD | In subjects of Hispanic/Native American (HNA): P-value=2.9E...... In subjects of Hispanic/Native American (HNA): P-value=2.9E-06. More... | It met the threshold for suggestive evidence of association ...... It met the threshold for suggestive evidence of association (P-value<5E-06). More... | Trend |
G*E study related association result (count: 1)
| Reference | Phenotype | Environment | Statistical Values | Author Comments | Marker's Category |
|---|---|---|---|---|---|
| Nievergelt, C. M.,2015 | PTSD | Childhood trauma | Gene and childhood trauma interaction: P-value<0.05 in any s...... Gene and childhood trauma interaction: P-value<0.05 in any subjects. More... | It showed a non-significant interaction effect with childhoo...... It showed a non-significant interaction effect with childhood trauma on PTSD. More... | Non-significant |
SNP related genes (count: 1)
| Approved Symbol | Approved Name | Location | No. of Association Results (Positive/Negative/Trend)  |
|---|---|---|---|
| POGK | pogo transposable element with KRAB domain | 1q23.2 | 1(0/0/1) |
SNPs in LD with rs2312236 (count: 2)
Literature-origin SNPs (count: 0)
LD-proxies (count: 2)
SNP related eQTL (count: 1)