PTSDgene database

Study Report

Study Information
Basic Info
Reference
Citation Tian, Y., et al. (2015). "Association of Genetic Factors and Gene-Environment Interactions With Risk of Developing Posttraumatic Stress Disorder in a Case-Control Study." Biol Res Nurs 17(4): 364-372.
Phenotype PTSD
Trauma 2008 Wenchuan earthquake
Study Design Case-control (longitudinal design)
Study Type Candidate gene association study, Gene-environment interaction study
Sample Size 64 cases and 119 controls
SNP/Marker Size 3 Variants
Predominant Ethnicity Mongoloid
Population Chinese Han
Gender 99 male (54.1%)
Age Mean age=14.84 years, SD=1.62.

Detail Info

Genetic result reported by this study
Normal genetic result reported by this study (count: 3)
Marker Phenotype Related Gene Statistical Values Author Comments Marker's Category
5-HTTVNTR PTSD SLC6A4 Allele frequence (10 vs 12): P-value=0.002. Genotype frequence (10/10 vs 10/12 vs 12/12): P-value<0.001. We found significant differences in the 5-HTTVNTR genotype b...... We found significant differences in the 5-HTTVNTR genotype between adolescents with and without PTSD, and the frequency of the 10 allele was significantly higher in those with PTSD compared with controls. More... Significant
DRD2_Taq 1 PTSD DRD2 Allele frequence (A1 vs A2): P-value=0.066. Genotype frequence (A1/A1 vs A1/A2 vs A2/A2): P-value=0.001. We found significant differences in the DRD2 Taq1 genotype b...... We found significant differences in the DRD2 Taq1 genotype between adolescents with and without PTSD, but the frequency of the allele was not significantly in those with PTSD compared with controls. More... Significant
5-HTTLPR PTSD SLC6A4 Allele frequence (L+ vs L vs S): P-value<0.001. Genotype frequence (LL vs LS vs L+S vs SS vs L+L): P-value<0.001. There were significant differences between adolescents with ...... There were significant differences between adolescents with and without PTSD for 5-HTTLPR genotype, and the allele frequencies also differed significantly between the two groups. More... Significant

Gene * Environment result reported by this study (count: 3)
Marker Phenotype Related Gene Environment Statistical Values Author Comments Marker's Category
5-HTTLPR PTSD SLC6A4 Earthquake exposure Interaction effect of genotype and earthquake exposure: OR=4.304, 95%CI=1.285-14.414, P-value=0.018. The interaction effects of this genotype with earthquake exp...... The interaction effects of this genotype with earthquake exposure was statistically significant. More... Significant
5-HTTVNTR PTSD SLC6A4 Earthquake exposure Interaction effect of genotype and earthquake exposure: OR=4.612, 95%CI=1.215-17.505, P-value=0.025. The interaction effects of this genotype with earthquake exp...... The interaction effects of this genotype with earthquake exposure was statistically significant. More... Significant
DRD2_Taq 1 PTSD DRD2 Earthquake exposure Interaction effect of genotype and earthquake exposure: OR=1.139, 95%CI=0.273-4.746, P-value=0.858. The interaction effects of this genotype with earthquake exp...... The interaction effects of this genotype with earthquake exposure was not statistically significant. More... Non-significant