Study Report
Reference | Tian, Y.,2015 PMID: 26002549 |
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Citation | Tian, Y., et al. (2015). "Association of Genetic Factors and Gene-Environment Interactions With Risk of Developing Posttraumatic Stress Disorder in a Case-Control Study." Biol Res Nurs 17(4): 364-372. |
Phenotype | PTSD |
Trauma | 2008 Wenchuan earthquake |
Study Design | Case-control (longitudinal design) |
Study Type | Candidate gene association study, Gene-environment interaction study |
Sample Size | 64 cases and 119 controls |
SNP/Marker Size | 3 Variants |
Predominant Ethnicity | Mongoloid |
Population | Chinese Han |
Gender | 99 male (54.1%) |
Age | Mean age=14.84 years, SD=1.62. |
Marker | Phenotype | Related Gene | Statistical Values | Author Comments | Marker's Category |
---|---|---|---|---|---|
5-HTTVNTR | PTSD | SLC6A4 | Allele frequence (10 vs 12): P-value=0.002. Genotype frequence (10/10 vs 10/12 vs 12/12): P-value<0.001. | We found significant differences in the 5-HTTVNTR genotype b...... We found significant differences in the 5-HTTVNTR genotype between adolescents with and without PTSD, and the frequency of the 10 allele was significantly higher in those with PTSD compared with controls. More... | Significant |
DRD2_Taq 1 | PTSD | DRD2 | Allele frequence (A1 vs A2): P-value=0.066. Genotype frequence (A1/A1 vs A1/A2 vs A2/A2): P-value=0.001. | We found significant differences in the DRD2 Taq1 genotype b...... We found significant differences in the DRD2 Taq1 genotype between adolescents with and without PTSD, but the frequency of the allele was not significantly in those with PTSD compared with controls. More... | Significant |
5-HTTLPR | PTSD | SLC6A4 | Allele frequence (L+ vs L vs S): P-value<0.001. Genotype frequence (LL vs LS vs L+S vs SS vs L+L): P-value<0.001. | There were significant differences between adolescents with ...... There were significant differences between adolescents with and without PTSD for 5-HTTLPR genotype, and the allele frequencies also differed significantly between the two groups. More... | Significant |
Marker | Phenotype | Related Gene | Environment | Statistical Values | Author Comments | Marker's Category |
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5-HTTLPR | PTSD | SLC6A4 | Earthquake exposure | Interaction effect of genotype and earthquake exposure: OR=4.304, 95%CI=1.285-14.414, P-value=0.018. | The interaction effects of this genotype with earthquake exp...... The interaction effects of this genotype with earthquake exposure was statistically significant. More... | Significant |
5-HTTVNTR | PTSD | SLC6A4 | Earthquake exposure | Interaction effect of genotype and earthquake exposure: OR=4.612, 95%CI=1.215-17.505, P-value=0.025. | The interaction effects of this genotype with earthquake exp...... The interaction effects of this genotype with earthquake exposure was statistically significant. More... | Significant |
DRD2_Taq 1 | PTSD | DRD2 | Earthquake exposure | Interaction effect of genotype and earthquake exposure: OR=1.139, 95%CI=0.273-4.746, P-value=0.858. | The interaction effects of this genotype with earthquake exp...... The interaction effects of this genotype with earthquake exposure was not statistically significant. More... | Non-significant |