PTSDgene database

Pathway Enrichment Analysis Protein-Protein Interaction Analysis

Study Report

Study Information

Basic Info

Reference	Tian, Y.,2015 PMID: 26002549
Citation	Tian, Y., et al. (2015). "Association of Genetic Factors and Gene-Environment Interactions With Risk of Developing Posttraumatic Stress Disorder in a Case-Control Study." Biol Res Nurs 17(4): 364-372.
Phenotype	PTSD
Trauma	2008 Wenchuan earthquake
Study Design	Case-control (longitudinal design)
Study Type	Candidate gene association study, Gene-environment interaction study
Sample Size	64 cases and 119 controls
SNP/Marker Size	3 Variants
Predominant Ethnicity	Mongoloid
Population	Chinese Han
Gender	99 male (54.1%)
Age	Mean age=14.84 years, SD=1.62.

Detail Info

Sample Diagnosis	DSM-IV
Related Diagnostic Tools	PTSD Checklist-Civilian Version (PCL-C), the Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders (DSM) criteria (SCID),
Sample Status	We undertook this study approximately 3 years after the 2008 Wenchuan earthquake in China, choosing three schools that had been severely struck by the earthquake from which to draw participants.
Controls Exposed	Yes
Replication Size	None
Result Summary	Results: The 5-HTTLPR and 5-HTTVNTR polymorphisms and earthquake exposure had statistically significant positive effects on PTSD. The interaction effects of 5-HTTLPR Earthquake Exposure and 5-HTTVNTR Earthquake Exposure were statistically significant. Conclusion: The development of PTSD is the result not only of a genetic effect and environmental factors but also of the interactive effect between gene and environment.
Potential Biomarker	None

Genetic result reported by this study

Normal genetic result reported by this study (count: 3)

Marker	Phenotype	Related Gene	Statistical Values	Author Comments	Marker's Category
5-HTTVNTR	PTSD	SLC6A4	Allele frequence (10 vs 12): P-value=0.002. Genotype frequence (10/10 vs 10/12 vs 12/12): P-value<0.001.	We found significant differences in the 5-HTTVNTR genotype b...... We found significant differences in the 5-HTTVNTR genotype between adolescents with and without PTSD, and the frequency of the 10 allele was significantly higher in those with PTSD compared with controls. More...	Significant
DRD2_Taq 1	PTSD	DRD2	Allele frequence (A1 vs A2): P-value=0.066. Genotype frequence (A1/A1 vs A1/A2 vs A2/A2): P-value=0.001.	We found significant differences in the DRD2 Taq1 genotype b...... We found significant differences in the DRD2 Taq1 genotype between adolescents with and without PTSD, but the frequency of the allele was not significantly in those with PTSD compared with controls. More...	Significant
5-HTTLPR	PTSD	SLC6A4	Allele frequence (L+ vs L vs S): P-value<0.001. Genotype frequence (LL vs LS vs L+S vs SS vs L+L): P-value<0.001.	There were significant differences between adolescents with ...... There were significant differences between adolescents with and without PTSD for 5-HTTLPR genotype, and the allele frequencies also differed significantly between the two groups. More...	Significant

Gene * Environment result reported by this study (count: 3)

Marker	Phenotype	Related Gene	Environment	Statistical Values	Author Comments	Marker's Category
5-HTTLPR	PTSD	SLC6A4	Earthquake exposure	Interaction effect of genotype and earthquake exposure: OR=4.304, 95%CI=1.285-14.414, P-value=0.018.	The interaction effects of this genotype with earthquake exp...... The interaction effects of this genotype with earthquake exposure was statistically significant. More...	Significant
5-HTTVNTR	PTSD	SLC6A4	Earthquake exposure	Interaction effect of genotype and earthquake exposure: OR=4.612, 95%CI=1.215-17.505, P-value=0.025.	The interaction effects of this genotype with earthquake exp...... The interaction effects of this genotype with earthquake exposure was statistically significant. More...	Significant
DRD2_Taq 1	PTSD	DRD2	Earthquake exposure	Interaction effect of genotype and earthquake exposure: OR=1.139, 95%CI=0.273-4.746, P-value=0.858.	The interaction effects of this genotype with earthquake exp...... The interaction effects of this genotype with earthquake exposure was not statistically significant. More...	Non-significant