Study Report

Study Information

Basic Info

Reference	Ashley-Koch, A. E.,2015 PMID: 26114229
Citation	Ashley-Koch, A. E., et al. (2015). "Genome-wide association study of posttraumatic stress disorder in a cohort of Iraq-Afghanistan era veterans." J Affect Disord 184: 225-234.
Phenotype	Current PTSD
Trauma	1929 Iraq/Afghanistan-era war
Study Design	Case-control
Study Type	Genome-wide association study, Gene-environment interaction study
Sample Size	949 NHB (current PTSD diagnosis 40.57%) and 759 NHW (current PTSD diagnosis 42.82%).
SNP/Marker Size	NHB:5,616,481 probes. NHW:5,016,226 probes.
Predominant Ethnicity	Caucasian, Black
Population	Non-Hispanic White, Non-Hispanic Black
Gender	NHB:69.65% male; NHW:84.85% male.
Age	NHB: mean age=39.06 years, SD=9.73. NHW: mean age=36.28 years, SD=10.44.

Detail Info

Sample Diagnosis	DSM-IV, DSM-IV-TR
Related Diagnostic Tools	The Structured Clinical Interview for DSM-IV Disorders (SCID). The Clinician-Administered PTSD Scale (CAPS).The Davidson Trauma Scale (DTS). The Traumatic Life Events Questionnaire (TLEQ).
Sample Status	Interviewers in all studies received extensive training and on-going supervision from clinical psychologists with expertize in the assessment and treatment of PTSD.
Controls Exposed	Yes
Replication Size	GWAS was initially performed separately for the NHB and NHW subsets of our data set.
Result Summary	Results:SNPs within several interesting candidate genes were nominally significant. Within the NHB subset, the most significant genes were UNC13C and DSCAM. Within the NHW subset, the most significant genes were TBC1D2, SDC2 and PCDH7. In addition, PRKG1 and DDX60L were identified through meta-analysis. The top genes for the three analyses have been previously implicated in neurologic processes consistent with a role in PTSD. Pathway analysis of the top genes identified alternative splicing as the top GO term in all three analyses (FDR q<3.5E-05). Limitations: No individual SNPs met genome-wide significance in the analyses. Conclusions: This multi-racial PTSD GWAS identified biologically plausible candidate genes and suggests that post-transcriptional regulation may be important to the pathology of PTSD; however, replication of these findings is needed.
Potential Biomarker	None

Genetic result reported by this study

Normal genetic result reported by this study (count: 16)

Marker	Phenotype	Related Gene	Statistical Values	Author Comments	Marker's Category
rs10768747	Current PTSD	Intergenic	In NHB subset: OR=1.66, main effect P-value=4.68E-06.	This SNP was nominally significant with current PTSD among t...... This SNP was nominally significant with current PTSD among the NHB subset (P-value More...	Trend
rs10762479	Current PTSD	PRKG1	In meta-analysis: main effect P-value=1.60E-05.	This SNP was nominally significant with current PTSD after m...... This SNP was nominally significant with current PTSD after mete-analysis of NHB and NHW subset (P-value More...	Trend
rs10170218	Current PTSD	LINC01090	In NHB P-value=0.35, in NHW P-value=0.75, meta-analysis P-value=0.53.	We didn't find significant evidence for this specific SNP in...... We didn't find significant evidence for this specific SNP in our study. More...	Non-significant
rs10002308	Current PTSD	DDX60L	In meta-analysis: main effect P-value=1.67E-05.	This SNP was nominally significant with current PTSD after m...... This SNP was nominally significant with current PTSD after mete-analysis of NHB and NHW subset (P-value More...	Trend
rs17504106	Current PTSD	Intergenic	In NHB subset: OR=2.97, main effect P-value=4.72E-06.	This SNP was nominally significant with current PTSD among t...... This SNP was nominally significant with current PTSD among the NHB subset (P-value More...	Trend
rs12232346	Current PTSD	LOC101928174	In meta-analysis: main effect P-value=2.14E-06.	This SNP was nominally significant with current PTSD after m...... This SNP was nominally significant with current PTSD after mete-analysis of NHB and NHW subset (P-value More...	Trend
rs1116255	Current PTSD	Intergenic	In NHW subset: OR=2.19, main effect P-value=5.46E-06.	This SNP was nominally significant with current PTSD among t...... This SNP was nominally significant with current PTSD among the NHW subset (P-value More...	Trend
rs6482463	Current PTSD	PRTFDC1	In NHB P-value=0.31, in NHW P-value=0.94, meta-analysis P-value=0.40.	We didn't find significant evidence for this specific SNP in...... We didn't find significant evidence for this specific SNP in our study. More...	Non-significant
rs61793204	Current PTSD	Intergenic	In NHW subset: OR=0.40, main effect P-value=8.60E-06.	This SNP was nominally significant with current PTSD among t...... This SNP was nominally significant with current PTSD among the NHW subset (P-value More...	Trend
rs2862383	Current PTSD	Intergenic	In NHB subset: OR=1.64, main effect P-value=6.17E-06.	This SNP was nominally significant with current PTSD among t...... This SNP was nominally significant with current PTSD among the NHB subset (P-value More...	Trend
rs2437772	Current PTSD	SDC2	In NHW subset: OR=0.56, main effect P-value=6.36E-06.	This SNP was nominally significant with current PTSD among t...... This SNP was nominally significant with current PTSD among the NHW subset (P-value More...	Trend
rs6812849	Current PTSD	TLL1	In NHB P-value=0.10, in NHW P-value=0.18, meta-analysis P-value=0.04.	The only gene for which we observed any nominal evidence for...... The only gene for which we observed any nominal evidence for association in our data set was TLL. More...	Non-significant
rs73419609	Current PTSD	UNC13C	In NHB subset: OR=0.45, main effect P-value=5.67E-06.	This SNP was nominally significant with current PTSD among t...... This SNP was nominally significant with current PTSD among the NHB subset (P-value More...	Trend
rs7866350	Current PTSD	TBC1D2	In NHW subset: OR=2.27, main effect P-value=1.10E-06.	This SNP was nominally significant with current PTSD among t...... This SNP was nominally significant with current PTSD among the NHW subset (P-value More...	Trend
rs8042149	Current PTSD	RORA	In NHB P-value=0.81, in NHW P-value=0.04, meta-analysis P-value=0.32.	The only gene for which we observed any nominal evidence for...... The only gene for which we observed any nominal evidence for association in our data set was RORA. More...	Non-significant
rs834811	Current PTSD	Intergenic	In NHB subset: OR=1.63, main effect P-value=7.31E-06.	This SNP was nominally significant with current PTSD among t...... This SNP was nominally significant with current PTSD among the NHB subset (P-value More...	Trend

Gene * Environment result reported by this study (count: 24)

Marker	Phenotype	Related Gene	Environment	Statistical Values	Author Comments	Marker's Category
rs17504106	Current PTSD	Intergenic	Childhood trauma	Logistic regression (additive genetic model) in NHB subset: snp and child trauma interaction P-value=0.37.	We haven't observed significant evidence for geneenvironmen...... We haven't observed significant evidence for geneenvironment interactions of this snp with childhood trauma. More...	Non-significant
rs17504106	Current PTSD	Intergenic	NTE (number of traumatic events)	Logistic regression (additive genetic model) in NHB subset: snp and total trauma interaction P-value=0.02.	Among the NHB, we observed nominally significant interaction...... Among the NHB, we observed nominally significant interactions with total trauma for this snp. More...	Non-significant
rs2437772	Current PTSD	SDC2	Childhood trauma	Logistic regression (additive genetic model) in NHW subset: snp and child trauma interaction P-value=0.56.	We haven't observed significant evidence for geneenvironmen...... We haven't observed significant evidence for geneenvironment interactions of this snp with childhood trauma. More...	Non-significant
rs2437772	Current PTSD	SDC2	NTE (number of traumatic events)	Logistic regression (additive genetic model) in NHW subset: snp and total trauma interaction P-value=0.26.	We haven't observed significant evidence for geneenvironmen...... We haven't observed significant evidence for geneenvironment interactions of this snp with total trauma. More...	Non-significant
rs1116255	Current PTSD	Intergenic	Childhood trauma	Logistic regression (additive genetic model) in NHW subset: snp and child trauma interaction P-value=0.37.	We haven't observed significant evidence for geneenvironmen...... We haven't observed significant evidence for geneenvironment interactions of this snp with childhood trauma. More...	Non-significant
rs1116255	Current PTSD	Intergenic	NTE (number of traumatic events)	Logistic regression (additive genetic model) in NHW subset: snp and total trauma interaction P-value=0.61.	We haven't observed significant evidence for geneenvironmen...... We haven't observed significant evidence for geneenvironment interactions of this snp with total trauma. More...	Non-significant
rs12232346	Current PTSD	LOC101928174	Childhood trauma	Logistic regression (additive genetic model) in NHB subset: snp and child trauma interaction P-value=0.94; in NHW subset: snp and child trauma interaction P-value=0.35.	We haven't observed significant evidence for geneenvironmen...... We haven't observed significant evidence for geneenvironment interactions of this snp with childhood trauma. More...	Non-significant
rs12232346	Current PTSD	LOC101928174	NTE (number of traumatic events)	Logistic regression (additive genetic model) in NHB subset: snp and total trauma interaction P-value=0.62; in NHW subset: snp and total trauma interaction P-value=0.74.	We haven't observed significant evidence for geneenvironmen...... We haven't observed significant evidence for geneenvironment interactions of this snp with total trauma. More...	Non-significant
rs73419609	Current PTSD	UNC13C	Childhood trauma	Logistic regression (additive genetic model) in NHB subset: snp and child trauma interaction P-value=0.049.	Among the NHB, we observed nominally significant interaction...... Among the NHB, we observed nominally significant interactions with childhood trauma for UNC13C. More...	Non-significant
rs73419609	Current PTSD	UNC13C	NTE (number of traumatic events)	Logistic regression (additive genetic model) in NHB subset: snp and total trauma interaction P-value=0.74.	We haven't observed significant evidence for geneenvironmen...... We haven't observed significant evidence for geneenvironment interactions of this snp with total trauma. More...	Non-significant
rs7866350	Current PTSD	TBC1D2	Childhood trauma	Logistic regression (additive genetic model) in NHW subset: snp and child trauma interaction P-value=0.51.	We haven't observed significant evidence for geneenvironmen...... We haven't observed significant evidence for geneenvironment interactions of this snp with childhood trauma. More...	Non-significant
rs7866350	Current PTSD	TBC1D2	NTE (number of traumatic events)	Logistic regression (additive genetic model) in NHW subset: snp and total trauma interaction P-value=0.15.	We haven't observed significant evidence for geneenvironmen...... We haven't observed significant evidence for geneenvironment interactions of this snp with total trauma. More...	Non-significant
rs2862383	Current PTSD	Intergenic	Childhood trauma	Logistic regression (additive genetic model) in NHB subset: snp and child trauma interaction P-value=0.15.	We haven't observed significant evidence for geneenvironmen...... We haven't observed significant evidence for geneenvironment interactions of this snp with childhood trauma. More...	Non-significant
rs2862383	Current PTSD	Intergenic	NTE (number of traumatic events)	Logistic regression (additive genetic model) in NHB subset: snp and total trauma interaction P-value=0.50.	We haven't observed significant evidence for geneenvironmen...... We haven't observed significant evidence for geneenvironment interactions of this snp with total trauma. More...	Non-significant
rs61793204	Current PTSD	Intergenic	Childhood trauma	Logistic regression (additive genetic model) in NHW subset: snp and child trauma interaction P-value=0.86.	We haven't observed significant evidence for geneenvironmen...... We haven't observed significant evidence for geneenvironment interactions of this snp with childhood trauma. More...	Non-significant
rs61793204	Current PTSD	Intergenic	NTE (number of traumatic events)	Logistic regression (additive genetic model) in NHW subset: snp and total trauma interaction P-value=0.82.	We haven't observed significant evidence for geneenvironmen...... We haven't observed significant evidence for geneenvironment interactions of this snp with total trauma. More...	Non-significant
rs834811	Current PTSD	Intergenic	NTE (number of traumatic events)	Logistic regression (additive genetic model) in NHB subset: snp and total trauma interaction P-value=0.21.	We haven't observed significant evidence for geneenvironmen...... We haven't observed significant evidence for geneenvironment interactions of this snp with total trauma. More...	Non-significant
rs834811	Current PTSD	Intergenic	Childhood trauma	Logistic regression (additive genetic model) in NHB subset: snp and child trauma interaction P-value=0.83.	We haven't observed significant evidence for geneenvironmen...... We haven't observed significant evidence for geneenvironment interactions of this snp with childhood trauma. More...	Non-significant
rs10002308	Current PTSD	DDX60L	NTE (number of traumatic events)	Logistic regression (additive genetic model) in NHB subset: snp and total trauma interaction P-value=0.88; in NHW subset: snp and total trauma interaction P-value=0.01.	The interaction between the total number of traumatic events...... The interaction between the total number of traumatic events and DDX60L in the NHW subset was nominally significant, consistent with the interaction observation with childhood trauma. More...	Non-significant
rs10002308	Current PTSD	DDX60L	Childhood trauma	Logistic regression (additive genetic model) in NHB subset: snp and child trauma interaction P-value=0.39; in NHW subset: snp and child trauma interaction P-value=0.046.	Among the NHW, we observed nominally significant interaction...... Among the NHW, we observed nominally significant interactions with childhood trauma for DDX60L. More...	Non-significant
rs10768747	Current PTSD	Intergenic	NTE (number of traumatic events)	Logistic regression (additive genetic model) in NHB subset: snp and total trauma interaction P-value=0.50.	We haven't observed significant evidence for geneenvironmen...... We haven't observed significant evidence for geneenvironment interactions of this snp with total trauma. More...	Non-significant
rs10768747	Current PTSD	Intergenic	Childhood trauma	Logistic regression (additive genetic model) in NHB subset: snp and child trauma interaction P-value=0.16.	We haven't observed significant evidence for geneenvironmen...... We haven't observed significant evidence for geneenvironment interactions of this snp with childhood trauma. More...	Non-significant
rs10762479	Current PTSD	PRKG1	NTE (number of traumatic events)	Logistic regression (additive genetic model) in NHB subset: snp and total trauma interaction P-value=0.61; in NHW subset: snp and total trauma interaction P-value=0.29.	We haven't observed significant evidence for geneenvironmen...... We haven't observed significant evidence for geneenvironment interactions of this snp with total trauma. More...	Non-significant
rs10762479	Current PTSD	PRKG1	Childhood trauma	Logistic regression (additive genetic model) in NHB subset: snp and child trauma interaction P-value=0.037; in NHW subset: snp and child trauma interaction P-value=0.94.	Among the NHB, we observed nominally significant interaction...... Among the NHB, we observed nominally significant interactions with childhood trauma for PRKG1. More...	Non-significant