PTSDgene database

SNP Report

Basic Info
Name rs74939664 dbSNP Ensembl
Location 1:82481654 - 82481654(+)
Variant Seq C
Ancestral Allele T
Ref Seq T
Minor Allele Frequence 0.033147
Annotation upstream_gene_variant
SIFT Annotation tolerated
SIFT Variant Effect tolerated(ENST00000627151, ENST00000370725, ENST00000449420, ENST00000370721, ENST00000370730, ENST00000402328, ENST00000370728, ENST00000319517, ENST00000370723, ENST00000370727, ENST00000370717, ENST00000359929)
PolyPhen Annotation benign; probably_damaging
PolyPhen Variant Effect benign(ENST00000449420); probably_damaging(ENST00000627151, ENST00000370725, ENST00000370721, ENST00000370730, ENST00000402328, ENST00000370728, ENST00000319517, ENST00000370723, ENST00000370727, ENST00000370717, ENST00000359929)
rSNP? Yes Link in rVarBase
Related Regulatory Elements n/a
Chromatin State Weak transcription
No. of Marker's Association Results 1 (Positive: 0; Negative: 0; Trend: 1)
Source Literature

SNP related association results
Normal genetic study related association results (count: 1)
Reference Phenotype Statistical Values Author Comments Marker's Category
Nievergelt, C. M.,2015 PTSD In subjects of European: P-value=2.0E-06. In subjects of European: P-value=2.0E-06. It met the threshold for suggestive evidence of association ...... It met the threshold for suggestive evidence of association (P-value<5E-06). More... Trend
G*E study related association result (count: 1)
Reference Phenotype Environment Statistical Values Author Comments Marker's Category
Nievergelt, C. M.,2015 PTSD Childhood trauma Gene and childhood trauma interaction: P-value<0.05 in any s...... Gene and childhood trauma interaction: P-value<0.05 in any subjects. More... It showed a non-significant interaction effect with childhoo...... It showed a non-significant interaction effect with childhood trauma on PTSD. More... Non-significant


SNP related genes (count: 1)
Approved Symbol Approved Name Location No. of Association Results (Positive/Negative/Trend)
ADGRL2 adhesion G protein-coupled receptor L2 1p31.1 1(0/0/1)

SNPs in LD with rs74939664 (count: 0)

SNP related eQTL (count: 1)
Gene Symbol Gene Existed in PTSDgene? Tissue Trans/Cis Source
CRHR1 Yes Adipose Subcutaneous cis GTEx