SNP Report
Basic Info
| Name | rs74939664 dbSNP Ensembl | ||
|---|---|---|---|
| Location | 1:82481654 - 82481654(+) | ||
| Variant Seq | C | ||
| Ancestral Allele | T | ||
| Ref Seq | T | ||
| Minor Allele Frequence | 0.033147 | ||
| Annotation | upstream_gene_variant | ||
| SIFT Annotation | tolerated | ||
| SIFT Variant Effect | tolerated(ENST00000627151, ENST00000370725, ENST00000449420, ENST00000370721, ENST00000370730, ENST00000402328, ENST00000370728, ENST00000319517, ENST00000370723, ENST00000370727, ENST00000370717, ENST00000359929) | ||
| PolyPhen Annotation | benign; probably_damaging | ||
| PolyPhen Variant Effect | benign(ENST00000449420); probably_damaging(ENST00000627151, ENST00000370725, ENST00000370721, ENST00000370730, ENST00000402328, ENST00000370728, ENST00000319517, ENST00000370723, ENST00000370727, ENST00000370717, ENST00000359929) | ||
| rSNP? | Yes Link in rVarBase | ||
| Related Regulatory Elements | n/a | ||
| Chromatin State | Weak transcription | ||
| No. of Marker's Association Results | 1 (Positive: 0; Negative: 0; Trend: 1) | ||
| Source | Literature | ||
SNP related association results
| Reference | Phenotype | Statistical Values | Author Comments | Marker's Category |
|---|---|---|---|---|
| Nievergelt, C. M.,2015 | PTSD | In subjects of European: P-value=2.0E-06. In subjects of European: P-value=2.0E-06. | It met the threshold for suggestive evidence of association ...... It met the threshold for suggestive evidence of association (P-value<5E-06). More... | Trend |
G*E study related association result (count: 1)
| Reference | Phenotype | Environment | Statistical Values | Author Comments | Marker's Category |
|---|---|---|---|---|---|
| Nievergelt, C. M.,2015 | PTSD | Childhood trauma | Gene and childhood trauma interaction: P-value<0.05 in any s...... Gene and childhood trauma interaction: P-value<0.05 in any subjects. More... | It showed a non-significant interaction effect with childhoo...... It showed a non-significant interaction effect with childhood trauma on PTSD. More... | Non-significant |
SNP related genes (count: 1)
| Approved Symbol | Approved Name | Location | No. of Association Results (Positive/Negative/Trend)  |
|---|---|---|---|
| ADGRL2 | adhesion G protein-coupled receptor L2 | 1p31.1 | 1(0/0/1) |
SNPs in LD with rs74939664 (count: 0)
SNP related eQTL (count: 1)