Gene Report

Basic Info

Approved Symbol	OXTR
Approved Name	oxytocin receptor
Location	3p25
Position	chr3:8750408-8769628, -1
External Links	HGNC: 8529 Entrez Gene: 5021 Ensembl: ENSG00000180914 UCSC: uc003brc.3
No. of Association Results	2 (Positive: 0; Negative: 2; trend: 0)
Annotation Type	Literature-origin, Mapped by Literature SNP, Mapped by LD-proxy

Gene related association results

Normal genetic study related association results (count: 2)

Reference	Phenotype	Marker	Gene's Category
Dunn, E. C.,2014	Post Traumatic Growth (PTG)	rs2254298 ; rs53576	Non-significant
Dunn, E. C.,2014	Post-traumatic stress symptoms (PTS)	rs2254298 ; rs53576	Non-significant

G*E study related association result (count: 1)

Reference	Phenotype	Environment	Marker	Gene's Category
Dunn, E. C.,2014	Post Traumatic Growth (PTG)	Hurricane exposure	rs2254298 ; rs53576	Non-significant

Gene functional annotation

Gene related GO terms (count: 49)

ID	Name	Type	Evidence[PMID]	No. of Genes in PTSDgene
GO:0034059	response to anoxia	biological process	IEA	1
GO:0007595	lactation	biological process	TAS[1313946]	3
GO:0042713	sperm ejaculation	biological process	IEA	2
GO:0060406	positive regulation of penile erection	biological process	IEA	2
GO:0005000	vasopressin receptor activity	molecular function	IBA	1
GO:0001967	suckling behavior	biological process	IEA	3
GO:0051968	positive regulation of synaptic transmission, glutamatergic	biological process	IEA	4
GO:0006936	muscle contraction	biological process	TAS[1313946]	3
GO:0042711	maternal behavior	biological process	IBA	3
GO:0032570	response to progesterone	biological process	IEA	2
GO:0042277	peptide binding	molecular function	IBA	3
GO:0042220	response to cocaine	biological process	IEA	7
GO:0048565	digestive tract development	biological process	IEA	4
GO:0005886	plasma membrane	cellular component	TAS	99
GO:0042755	eating behavior	biological process	IEA	4
GO:0005829	cytosol	cellular component	IEA	78
GO:0070371	ERK1 and ERK2 cascade	biological process	IEA	2
GO:0007204	positive regulation of cytosolic calcium ion concentration	biological process	IEA	7
GO:0001992	regulation of systemic arterial blood pressure by vasopressin	biological process	IBA	1
GO:0044849	estrous cycle	biological process	IEA	3
GO:0001975	response to amphetamine	biological process	IEA	9
GO:0005887	integral component of plasma membrane	cellular component	TAS[10858434]	36
GO:0060455	negative regulation of gastric acid secretion	biological process	IEA	1
GO:0005913	cell-cell adherens junction	cellular component	IEA	2
GO:0060137	maternal process involved in parturition	biological process	IEA	1
GO:0030431	sleep	biological process	IEA	3
GO:0007565	female pregnancy	biological process	IEA	9
GO:0042493	response to drug	biological process	IEA	25
GO:0032230	positive regulation of synaptic transmission, GABAergic	biological process	IEA	2
GO:0016324	apical plasma membrane	cellular component	IEA	6
GO:0007507	heart development	biological process	IEA	6
GO:0021537	telencephalon development	biological process	IEA	1
GO:0032870	cellular response to hormone stimulus	biological process	IBA	2
GO:0007613	memory	biological process	IEA	11
GO:0034097	response to cytokine	biological process	IEA	1
GO:0070474	positive regulation of uterine smooth muscle contraction	biological process	IEA	1
GO:0007186	G-protein coupled receptor signaling pathway	biological process	IEA	14
GO:0017046	peptide hormone binding	molecular function	IEA	3
GO:0007166	cell surface receptor signaling pathway	biological process	TAS[1313946]	16
GO:0035176	social behavior	biological process	IBA	9
GO:0045907	positive regulation of vasoconstriction	biological process	IBA	3
GO:0045777	positive regulation of blood pressure	biological process	IEA	3
GO:0010701	positive regulation of norepinephrine secretion	biological process	IEA	1
GO:0005902	microvillus	cellular component	IEA	2
GO:0051965	positive regulation of synapse assembly	biological process	IEA	6
GO:1901652	response to peptide	biological process	IBA	1
GO:0004990	oxytocin receptor activity	molecular function	IEA	1
GO:0043434	response to peptide hormone	biological process	IEA	6
GO:0032355	response to estradiol	biological process	IEA	9

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in PTSDgene
hsa04020	Calcium signaling pathway	11
hsa04080	Neuroactive ligand-receptor interaction	22

Gene related interactors from protein-protein interactions data in PINA v2 (count: 3)

Gene	Interactor	Interactor in PTSDgene?	Experiment Method	Interaction Type	PMID
OXTR	GRK5	No	--	--	10858434
OXTR	ARRB2	No	--	--	11279203
OXTR	GPRASP1	No	--	--	15452121