Gene Report

Basic Info

Approved Symbol	DRD4
Approved Name	dopamine receptor D4
Location	11p15.5
Position	chr11:637293-640706, 1
External Links	HGNC: 3025 Entrez Gene: 1815 Ensembl: ENSG00000069696 UCSC: uc001lqp.2
No. of Association Results	7 (Positive: 2; Negative: 5; trend: 0)
Annotation Type	Literature-origin, Mapped by Literature SNP

Gene related association results

Normal genetic study related association results (count: 7)

Reference	Phenotype	Marker	Gene's Category
Dragan, W. L.,2009	Avoidance/Numbing symptoms	DRD4_exon3_VNTR	Significant
Dragan, W. L.,2009	Intrusion/Arousal symptoms	DRD4_exon3_VNTR	Non-significant
Dragan, W. L.,2009	PTSD-C score	DRD4_exon3_VNTR	Significant
Dragan, W. L.,2009	PTSD-F score	DRD4_exon3_VNTR	Non-significant
Nievergelt, C. M.,2015	PTSD	rs4987059	Non-significant
Solovieff, N.,2014	PTSD diagnosis	rs7126715	Non-significant
Solovieff, N.,2014	PTSD severity	rs752306	Non-significant

G*E study related association result (count: 1)

Reference	Phenotype	Environment	Marker	Gene's Category
Nievergelt, C. M.,2015	PTSD	Childhood trauma	rs4987059	Non-significant

Gene functional annotation

Gene related GO terms (count: 52)

ID	Name	Type	Evidence[PMID]	No. of Genes in PTSDgene
GO:0004952	dopamine neurotransmitter receptor activity	molecular function	IDA[8413587]	1
GO:0043195	terminal bouton	cellular component	IEA	7
GO:0043025	neuronal cell body	cellular component	IEA	18
GO:0051586	positive regulation of dopamine uptake involved in synaptic transmission	biological process	IC[1840645]	2
GO:0001975	response to amphetamine	biological process	ISS	9
GO:1901386	negative regulation of voltage-gated calcium channel activity	biological process	IDA[7921596]	4
GO:0035240	dopamine binding	molecular function	IDA[1319557]	6
GO:0050482	arachidonic acid secretion	biological process	IDA[7512953]	3
GO:0007195	adenylate cyclase-inhibiting dopamine receptor signaling pathway	biological process	IDA[7512953]	3
GO:0030818	negative regulation of cAMP biosynthetic process	biological process	IDA[7512953\|9843378]	3
GO:0050848	regulation of calcium-mediated signaling	biological process	IEA	2
GO:0007614	short-term memory	biological process	IEA	2
GO:0016020	membrane	cellular component	IDA[7512953]	42
GO:0032417	positive regulation of sodium:proton antiporter activity	biological process	IDA[7512953]	1
GO:0012506	vesicle membrane	cellular component	IEA	3
GO:0042053	regulation of dopamine metabolic process	biological process	ISS	3
GO:0046928	regulation of neurotransmitter secretion	biological process	IEA	2
GO:0007212	dopamine receptor signaling pathway	biological process	IDA[1840645]	1
GO:0001963	synaptic transmission, dopaminergic	biological process	IBA	5
GO:0035176	social behavior	biological process	NAS[11126393\|11409696]	9
GO:0042802	identical protein binding	molecular function	IPI[21320289]	10
GO:0033674	positive regulation of kinase activity	biological process	IDA[15755724]	1
GO:0005938	cell cortex	cellular component	IEA	4
GO:0048545	response to steroid hormone	biological process	IEA	2
GO:0050709	negative regulation of protein secretion	biological process	IDA[16839358]	4
GO:0009648	photoperiodism	biological process	IEA	1
GO:0060080	inhibitory postsynaptic potential	biological process	ISS	3
GO:0008144	drug binding	molecular function	IDA[1319557\|1840645\|8413587]	13
GO:0008355	olfactory learning	biological process	IEA	2
GO:0015459	potassium channel regulator activity	molecular function	NAS[12297500]	4
GO:0048149	behavioral response to ethanol	biological process	TAS[12888781]	4
GO:0042596	fear response	biological process	ISS	2
GO:0005887	integral component of plasma membrane	cellular component	IDA[8413587\|9843378\|15755724]	36
GO:0001588	dopamine neurotransmitter receptor activity, coupled via Gs	molecular function	IBA	2
GO:0042752	regulation of circadian rhythm	biological process	ISS	1
GO:2000463	positive regulation of excitatory postsynaptic potential	biological process	IEA	4
GO:0060406	positive regulation of penile erection	biological process	IEA	2
GO:0060041	retina development in camera-type eye	biological process	IEA	6
GO:0007194	negative regulation of adenylate cyclase activity	biological process	IDA[7512953]	5
GO:0007623	circadian rhythm	biological process	IEA	5
GO:0008344	adult locomotory behavior	biological process	ISS	2
GO:0034776	response to histamine	biological process	IDA[16839358]	3
GO:0000187	activation of MAPK activity	biological process	IDA[9843378\|15755724]	8
GO:0005515	protein binding	molecular function	IPI[12297500]	169
GO:0048148	behavioral response to cocaine	biological process	ISS	5
GO:0005886	plasma membrane	cellular component	IDA[20531939]; TAS	99
GO:0017124	SH3 domain binding	molecular function	IDA[9843378]	5
GO:0042417	dopamine metabolic process	biological process	IC[1840645]	4
GO:0043197	dendritic spine	cellular component	IEA	9
GO:0006874	cellular calcium ion homeostasis	biological process	IC[7921596]	9
GO:0001662	behavioral fear response	biological process	NAS[12860355]	7
GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go	molecular function	IDA[1840645]; ISS	3

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in PTSDgene
hsa04080	Neuroactive ligand-receptor interaction	22

Gene related interactors from protein-protein interactions data in PINA v2 (count: 8)

Gene	Interactor	Interactor in PTSDgene?	Experiment Method	Interaction Type	PMID
DRD4	GRB2	No	--	--	9843378 , 9843378
DRD4	STUB1	No	--	--	20974815
DRD4	KLHL12	No	--	--	18303015 , 20100572 , 20100572
DRD4	KCNJ3	No	--	--	12297500
DRD4	KCNJ5	No	--	--	12297500
DRD4	CLIC6	No	--	--	14499480 , 14499480
DRD4	ARRB2	No	--	--	20100572
DRD4	KCNJ9	No	--	--	12297500 , 12297500