PTSDgene database

Study Report

Study Information
Basic Info
Reference Solovieff, N.,2014 PMID: 24525708
Citation Solovieff, N., et al. (2014). "Genetic association analysis of 300 genes identifies a risk haplotype in SLC18A2 for post-traumatic stress disorder in two independent samples." Neuropsychopharmacology 39(8): 1872-1879.
Phenotype PTSD severity, PTSD diagnosis
Trauma Various
Study Design Case-control
Study Type Candidate gene association study
Sample Size 845 cases, 1693 controls
SNP/Marker Size 3,742 SNPs, 1 Variant
Predominant Ethnicity Caucasian
Population European-American
Gender All females
Age Mean age=55.6 years, SD=4.5

Detail Info

Genetic result reported by this study
Normal genetic result reported by this study (count: 45)
Marker Phenotype Related Gene Statistical Values Author Comments Marker's Category
rs10507545 PTSD diagnosis HTR2A P-value=0.054 Achieved nominal levels of significance with PTSD diagnosis,...... Achieved nominal levels of significance with PTSD diagnosis, although was not significant after correction for multiple testing More... Non-significant
rs7701443 PTSD diagnosis NR3C1 P-value=0.059 Achieved nominal levels of significance with PTSD diagnosis,...... Achieved nominal levels of significance with PTSD diagnosis, although was not significant after correction for multiple testing More... Non-significant
rs11564751 PTSD diagnosis SLC6A3 P-value=0.056 Achieved nominal levels of significance with PTSD diagnosis,...... Achieved nominal levels of significance with PTSD diagnosis, although was not significant after correction for multiple testing More... Non-significant
rs7126715 PTSD diagnosis DRD4 P-value=0.210 Achieved nominal levels of significance with PTSD diagnosis,...... Achieved nominal levels of significance with PTSD diagnosis, although was not significant after correction for multiple testing More... Non-significant
rs1124492 PTSD diagnosis DRD2 P-value=0.266 Achieved nominal levels of significance with PTSD diagnosis,...... Achieved nominal levels of significance with PTSD diagnosis, although was not significant after correction for multiple testing More... Non-significant
rs693547 PTSD diagnosis GABRA2 P-value=0.083 Achieved nominal levels of significance with PTSD diagnosis,...... Achieved nominal levels of significance with PTSD diagnosis, although was not significant after correction for multiple testing More... Non-significant
rs6650088 PTSD diagnosis RGS2 P-value=0.079 Achieved nominal levels of significance with PTSD diagnosis,...... Achieved nominal levels of significance with PTSD diagnosis, although was not significant after correction for multiple testing More... Non-significant
rs11606304 PTSD diagnosis TPH1 P-value=0.077 Achieved nominal levels of significance with PTSD diagnosis,...... Achieved nominal levels of significance with PTSD diagnosis, although was not significant after correction for multiple testing More... Non-significant
rs584007 PTSD diagnosis APOE P-value=0.066 Achieved nominal levels of significance with PTSD diagnosis,...... Achieved nominal levels of significance with PTSD diagnosis, although was not significant after correction for multiple testing More... Non-significant
rs12939390 PTSD diagnosis SLC6A4 P-value=0.006 Achieved nominal levels of significance with PTSD diagnosis,...... Achieved nominal levels of significance with PTSD diagnosis, although was not significant after correction for multiple testing More... Non-significant
rs10082463 - rs2015586 - rs363223 - rs363256 - rs363230 - rs363272 - rs2244249 - rs363276 - rs363279, CGGCGGAAG PTSD diagnosis SLC18A2 In the NHSII sample: P-value=0.0046, in the DNHS sample: P-value=0.049 A haplotype analysis of 9 SNPs in SLC18A2, including rs36327...... A haplotype analysis of 9 SNPs in SLC18A2, including rs363276, identified a risk haplotype and the same risk haplotype was associated with PTSD in an independent cohort of trauma-exposed African-Americans. More... Significant
rs17110747 PTSD diagnosis TPH2 P-value=0.163 Achieved nominal levels of significance with PTSD diagnosis,...... Achieved nominal levels of significance with PTSD diagnosis, although was not significant after correction for multiple testing More... Non-significant
rs1076153 PTSD severity DBH P-value=0.154 Achieved nominal levels of significance with PTSD severity, ...... Achieved nominal levels of significance with PTSD severity, although was not significant after correction for multiple testing More... Non-significant
rs165774 PTSD diagnosis COMT P-value=0.015 Achieved nominal levels of significance with PTSD diagnosis,...... Achieved nominal levels of significance with PTSD diagnosis, although was not significant after correction for multiple testing More... Non-significant
rs16472 PTSD diagnosis NPY P-value=0.358 Achieved nominal levels of significance with PTSD diagnosis,...... Achieved nominal levels of significance with PTSD diagnosis, although was not significant after correction for multiple testing More... Non-significant
rs806377 PTSD diagnosis CNR1 P-value=0.125 Achieved nominal levels of significance with PTSD diagnosis,...... Achieved nominal levels of significance with PTSD diagnosis, although was not significant after correction for multiple testing More... Non-significant
rs2073837 PTSD diagnosis DBH P-value=0.071 Achieved nominal levels of significance with PTSD diagnosis,...... Achieved nominal levels of significance with PTSD diagnosis, although was not significant after correction for multiple testing More... Non-significant
rs2576573 PTSD severity PENK B=-0.047, P-value=5.5E-05, corrected P-value=0.131 The next most significant SNP was rs2576573 with the A allel...... The next most significant SNP was rs2576573 with the A allele associated with lower PTSD symptoms. More... Significant
rs242941 PTSD severity CRHR1 P-value=0.144 Achieved nominal levels of significance with PTSD severity, ...... Achieved nominal levels of significance with PTSD severity, although was not significant after correction for multiple testing More... Non-significant
rs276651 PTSD severity FKBP5 P-value=0.089 Achieved nominal levels of significance with PTSD severity, ...... Achieved nominal levels of significance with PTSD severity, although was not significant after correction for multiple testing More... Non-significant
rs2746073 PTSD severity RGS2 P-value=0.355 Achieved nominal levels of significance with PTSD severity, ...... Achieved nominal levels of significance with PTSD severity, although was not significant after correction for multiple testing More... Non-significant
rs363276 PTSD severity SLC18A2 B=0.032, P-value=5.0E-02 No detail information. No detail information. Non-significant
rs3213207 PTSD severity DTNBP1 P-value=0.434 Achieved nominal levels of significance with PTSD severity, ...... Achieved nominal levels of significance with PTSD severity, although was not significant after correction for multiple testing More... Non-significant
rs584007 PTSD severity APOE P-value=0.020 Achieved nominal levels of significance with PTSD severity, ...... Achieved nominal levels of significance with PTSD severity, although was not significant after correction for multiple testing More... Non-significant
rs4274224 PTSD severity DRD2 P-value=0.237 Achieved nominal levels of significance with PTSD severity, ...... Achieved nominal levels of significance with PTSD severity, although was not significant after correction for multiple testing More... Non-significant
rs11606304 PTSD severity TPH1 P-value=0.120 Achieved nominal levels of significance with PTSD severity, ...... Achieved nominal levels of significance with PTSD severity, although was not significant after correction for multiple testing More... Non-significant
rs11564751 PTSD severity SLC6A3 P-value=0.009 Achieved nominal levels of significance with PTSD severity, ...... Achieved nominal levels of significance with PTSD severity, although was not significant after correction for multiple testing More... Non-significant
rs1464896 PTSD severity BDNF P-value=0.062 Achieved nominal levels of significance with PTSD severity, ...... Achieved nominal levels of significance with PTSD severity, although was not significant after correction for multiple testing More... Non-significant
rs12939390 PTSD severity SLC6A4 P-value=0.003 Achieved nominal levels of significance with PTSD severity, ...... Achieved nominal levels of significance with PTSD severity, although was not significant after correction for multiple testing More... Non-significant
rs165774 PTSD severity COMT P-value=0.034 Achieved nominal levels of significance with PTSD severity, ...... Achieved nominal levels of significance with PTSD severity, although was not significant after correction for multiple testing More... Non-significant
rs16472 PTSD severity NPY P-value=0.362 Achieved nominal levels of significance with PTSD severity, ...... Achieved nominal levels of significance with PTSD severity, although was not significant after correction for multiple testing More... Non-significant
rs2284225 PTSD severity ADCYAP1R1 P-value=0.304 Achieved nominal levels of significance with PTSD severity, ...... Achieved nominal levels of significance with PTSD severity, although was not significant after correction for multiple testing More... Non-significant
rs17537141 PTSD severity GABRA2 P-value=0.303 Achieved nominal levels of significance with PTSD severity, ...... Achieved nominal levels of significance with PTSD severity, although was not significant after correction for multiple testing More... Non-significant
rs2140887 PTSD diagnosis BDNF P-value=0.012 Achieved nominal levels of significance with PTSD diagnosis,...... Achieved nominal levels of significance with PTSD diagnosis, although was not significant after correction for multiple testing More... Non-significant
rs7300641 PTSD severity TPH2 P-value=0.048 Achieved nominal levels of significance with PTSD severity, ...... Achieved nominal levels of significance with PTSD severity, although was not significant after correction for multiple testing More... Non-significant
rs2576573 PTSD diagnosis PENK OR=0.83, P-value=2.6E-03 No detail information. No detail information. Non-significant
rs752306 PTSD severity DRD4 P-value=0.292 Achieved nominal levels of significance with PTSD severity, ...... Achieved nominal levels of significance with PTSD severity, although was not significant after correction for multiple testing More... Non-significant
rs7701443 PTSD severity NR3C1 P-value=0.209 Achieved nominal levels of significance with PTSD severity, ...... Achieved nominal levels of significance with PTSD severity, although was not significant after correction for multiple testing More... Non-significant
rs2766581 PTSD diagnosis FKBP5 P-value=0.041 Achieved nominal levels of significance with PTSD diagnosis,...... Achieved nominal levels of significance with PTSD diagnosis, although was not significant after correction for multiple testing More... Non-significant
rs7766029 PTSD severity CNR1 P-value=0.156 Achieved nominal levels of significance with PTSD severity, ...... Achieved nominal levels of significance with PTSD severity, although was not significant after correction for multiple testing More... Non-significant
rs363276 PTSD diagnosis SLC18A2 OR=1.42, P-value=2.1E-05, corrected P-value=0.045 Rs363276 was the most significant SNP and had an OR of 1.4 w...... Rs363276 was the most significant SNP and had an OR of 1.4 with PTSD cases having an excess of the A allele as compared with the controls. More... Significant
rs9534507 PTSD severity HTR2A P-value=0.027 Achieved nominal levels of significance with PTSD severity, ...... Achieved nominal levels of significance with PTSD severity, although was not significant after correction for multiple testing More... Non-significant
rs10226318 PTSD diagnosis ADCYAP1R1 P-value=0.161 Achieved nominal levels of significance with PTSD diagnosis,...... Achieved nominal levels of significance with PTSD diagnosis, although was not significant after correction for multiple testing More... Non-significant
rs1011313 PTSD diagnosis DTNBP1 P-value=0.096 Achieved nominal levels of significance with PTSD diagnosis,...... Achieved nominal levels of significance with PTSD diagnosis, although was not significant after correction for multiple testing More... Non-significant
rs242941 PTSD diagnosis CRHR1 P-value=0.084 Achieved nominal levels of significance with PTSD diagnosis,...... Achieved nominal levels of significance with PTSD diagnosis, although was not significant after correction for multiple testing More... Non-significant

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Last update: April 1, 2018