PTSDgene database

SNP Report

Basic Info
Name rs584007 dbSNP Ensembl
Location 19:44913221 - 44913221(+)
Variant Seq G
Ref Seq A
Minor Allele Frequence 0.402955
Annotation downstream_gene_variant; non_coding_transcript_exon_variant; upstream_gene_variant; non_coding_transcript_variant
Variant Effect downstream_gene_variant(ENST00000446996, ENST00000425718, ENST00000434152, ENST00000252486); non_coding_transcript_exon_variant(ENST00000623895); upstream_gene_variant(ENST00000592535, ENST00000586638, ENST00000589781, ENST00000588750, ENST00000590334, ENST00000588802, ENST00000592885, ENST00000592176, ENST00000589078); non_coding_transcript_variant(ENST00000623895)
SIFT Annotation deleterious_-_low_confidence; deleterious
SIFT Variant Effect deleterious_-_low_confidence(ENST00000592885, ENST00000586638); deleterious(ENST00000588750, ENST00000592535, ENST00000588802)
PolyPhen Annotation unknown; benign; possibly_damaging
PolyPhen Variant Effect unknown(ENST00000586638); benign(ENST00000588750, ENST00000592535, ENST00000588802); possibly_damaging(ENST00000592885)
rSNP? Yes Link in rVarBase
Related Regulatory Elements TF binding region;Chromatin interactive region
Chromatin State Enhancers;Weak transcription;Flanking Active TSS;Bivalent Enhancer
No. of Marker's Association Results 2 (Positive: 0; Negative: 2; Trend: 0)
Source Literature

SNP related association results
Normal genetic study related association results (count: 2)
Reference Phenotype Statistical Values Author Comments Marker's Category
Solovieff, N.,2014 PTSD diagnosis P-value=0.066 P-value=0.066 Achieved nominal levels of significance with PTSD diagnosis,...... Achieved nominal levels of significance with PTSD diagnosis, although was not significant after correction for multiple testing More... Non-significant
Solovieff, N.,2014 PTSD severity P-value=0.020 P-value=0.020 Achieved nominal levels of significance with PTSD severity, ...... Achieved nominal levels of significance with PTSD severity, although was not significant after correction for multiple testing More... Non-significant


SNP related genes (count: 4)
Approved Symbol Approved Name Location No. of Association Results (Positive/Negative/Trend)
APOE apolipoprotein E 19q13.31 6(2/4/0)
APOC1 apolipoprotein C-I 19q13.2 Mapped by Literature SNP, Mapped by LD-proxy
PPP1R37 protein phosphatase 1 regulatory subunit 37 19q13.32 rSNP target
APOC4 apolipoprotein C-IV 19q13.2 rSNP target

SNPs in LD with rs584007 (count: 4)
The LD data used here is based on 1000 Genome Phase I. LD SNP pairs were selected with a threshold r2<=0.8.

Literature-origin SNPs (count: 0)

LD-proxies (count: 4)


SNP related eQTL (count: 1)
Gene Symbol Gene Existed in PTSDgene? Tissue Trans/Cis Source
RP5-1109J22.1 No Adipose Subcutaneous cis GTEx