Gene Report

Basic Info

Approved Symbol	DBH
Symbol Alias	DBM
Approved Name	dopamine beta-hydroxylase (dopamine beta-monooxygenase)
Location	9q34
Position	chr9:133636360-133659344, 1
External Links	HGNC: 2689 Entrez Gene: 1621 Ensembl: ENSG00000123454 UCSC: uc004cel.3
No. of Association Results	4 (Positive: 0; Negative: 4; trend: 0)
Annotation Type	Literature-origin, Mapped by Literature SNP, Mapped by LD-proxy

Gene related association results

Normal genetic study related association results (count: 4)

Reference	Phenotype	Marker	Gene's Category
Mustapic, M.,2007	Chronic PTSD	rs1611115	Non-significant
Nelson, E. C.,2014	PTSD	rs2519154	Non-significant
Solovieff, N.,2014	PTSD diagnosis	rs2073837	Non-significant
Solovieff, N.,2014	PTSD severity	rs1076153	Non-significant

Gene functional annotation

Gene related GO terms (count: 36)

ID	Name	Type	Evidence[PMID]	No. of Genes in PTSDgene
GO:0005507	copper ion binding	molecular function	IEA	3
GO:0007613	memory	biological process	IEA	11
GO:0016020	membrane	cellular component	TAS[3443096]	42
GO:0031418	L-ascorbic acid binding	molecular function	IEA	1
GO:0042423	catecholamine biosynthetic process	biological process	TAS	3
GO:0002443	leukocyte mediated immunity	biological process	IEA	1
GO:0042309	homoiothermy	biological process	IEA	1
GO:0042420	dopamine catabolic process	biological process	IEA	5
GO:0001975	response to amphetamine	biological process	IEA	9
GO:0001816	cytokine production	biological process	IEA	1
GO:0050900	leukocyte migration	biological process	IEA	3
GO:0003824	catalytic activity	molecular function	TAS[3443096]	1
GO:0048149	behavioral response to ethanol	biological process	IEA	4
GO:0034466	chromaffin granule lumen	cellular component	IEA	1
GO:0042596	fear response	biological process	IEA	2
GO:0008542	visual learning	biological process	IEA	6
GO:0042593	glucose homeostasis	biological process	IEA	7
GO:0042421	norepinephrine biosynthetic process	biological process	IEA	2
GO:0030658	transport vesicle membrane	cellular component	IEA	3
GO:0044281	small molecule metabolic process	biological process	TAS	38
GO:0042127	regulation of cell proliferation	biological process	IEA	2
GO:0034774	secretory granule lumen	cellular component	TAS	2
GO:0004500	dopamine beta-monooxygenase activity	molecular function	TAS	1
GO:0005737	cytoplasm	cellular component	TAS[3443096]	109
GO:0016021	integral component of membrane	cellular component	IEA	56
GO:0005576	extracellular region	cellular component	NAS[14718574]	31
GO:0007626	locomotory behavior	biological process	IEA	9
GO:0048265	response to pain	biological process	IEA	4
GO:0045907	positive regulation of vasoconstriction	biological process	IEA	3
GO:0042584	chromaffin granule membrane	cellular component	IEA	1
GO:0034641	cellular nitrogen compound metabolic process	biological process	TAS	11
GO:0001974	blood vessel remodeling	biological process	IEA	1
GO:0055114	oxidation-reduction process	biological process	IEA	18
GO:0042711	maternal behavior	biological process	IEA	3
GO:2001236	regulation of extrinsic apoptotic signaling pathway	biological process	IEA	1
GO:0007268	synaptic transmission	biological process	TAS[2880016]	32

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in PTSDgene
hsa00350	Tyrosine metabolism	5

Gene related interactors from protein-protein interactions data in PINA v2 (count: 3)

Gene	Interactor	Interactor in PTSDgene?	Experiment Method	Interaction Type	PMID
DBH	ITSN1	No	--	colocalization	16874303 , 16874303 , 16874303
DBH	PRADC1	No	--	--	15498570
DBH	CLN3	No	--	--	23464991