SNP Report

Basic Info

Name	rs165774 dbSNP Ensembl
Location	22:19965038 - 19965038(+)
Variant Seq	A
Ancestral Allele	G
Ref Seq	G
Minor Allele Frequence	0.203075
Annotation	downstream_gene_variant; 3_prime_UTR_variant; intron_variant; NMD_transcript_variant
Variant Effect	downstream_gene_variant(ENST00000585066, ENST00000263207, ENST00000467943, ENST00000493893, ENST00000495096); 3_prime_UTR_variant(ENST00000403184); intron_variant(ENST00000428707, ENST00000403710, ENST00000412786, ENST00000207636, ENST00000407537, ENST00000449653, ENST00000406520, ENST00000361682); NMD_transcript_variant(ENST00000207636)
SIFT Annotation	tolerated
SIFT Variant Effect	tolerated(ENST00000207636, ENST00000412786, ENST00000361682, ENST00000403184, ENST00000403710, ENST00000406520, ENST00000407537)
PolyPhen Annotation	benign
PolyPhen Variant Effect	benign(ENST00000207636, ENST00000412786, ENST00000361682, ENST00000403184, ENST00000403710, ENST00000406520, ENST00000407537)
rSNP?	No Link in rVarBase
Related Regulatory Elements	N.A.
Chromatin State	N.A.
No. of Marker's Association Results	2 (Positive: 0; Negative: 2; Trend: 0)
Source	Literature

SNP related association results

Normal genetic study related association results (count: 2)

Reference	Phenotype	Statistical Values	Author Comments	Marker's Category
Solovieff, N.,2014	PTSD diagnosis	P-value=0.015 P-value=0.015	Achieved nominal levels of significance with PTSD diagnosis,...... Achieved nominal levels of significance with PTSD diagnosis, although was not significant after correction for multiple testing More...	Non-significant
Solovieff, N.,2014	PTSD severity	P-value=0.034 P-value=0.034	Achieved nominal levels of significance with PTSD severity, ...... Achieved nominal levels of significance with PTSD severity, although was not significant after correction for multiple testing More...	Non-significant

SNP related genes (count: 2)

Approved Symbol	Approved Name	Location	No. of Association Results (Positive/Negative/Trend)
ARVCF	armadillo repeat gene deleted in velocardiofacial syndrome	22q11.21	Mapped by Literature SNP, Mapped by LD-proxy
COMT	catechol-O-methyltransferase	22q11.21	21(9/12/0)

SNPs in LD with rs165774 (count: 1)

The LD data used here is based on 1000 Genome Phase I. LD SNP pairs were selected with a threshold r²<=0.8.

rs_ID	Literature-origin SNPs with LD	Annotation	r²[population]
rs165737	rs165774	downstream_gene_variant; 3_prime_UTR_variant; intron_variant; NMD_transcript_variant	1.0000[EUR]

SNP related eQTL (count: 1)

Gene Symbol	Gene Existed in PTSDgene?	Tissue	Trans/Cis	Source
FBLL1	No	Adipose Subcutaneous	cis	GTEx