SNP Report

Basic Info

Name	rs2284225 dbSNP Ensembl
Location	7:31098889 - 31098889(+)
Variant Seq	A
Ancestral Allele	G
Ref Seq	G
Minor Allele Frequence	0.405551
Annotation	intron_variant
Variant Effect	intron_variant(ENST00000436116, ENST00000614107, ENST00000409363, ENST00000409489, ENST00000304166, ENST00000396211)
SIFT Annotation	deleterious
SIFT Variant Effect	deleterious(ENST00000614107, ENST00000409363, ENST00000396211, ENST00000304166, ENST00000409489)
PolyPhen Annotation	probably_damaging
PolyPhen Variant Effect	probably_damaging(ENST00000614107, ENST00000409363, ENST00000396211, ENST00000304166, ENST00000409489)
rSNP?	Yes Link in rVarBase
Related Regulatory Elements	n/a
Chromatin State	Weak transcription;Strong transcription
No. of Marker's Association Results	1 (Positive: 0; Negative: 1; Trend: 0)
Source	Literature

SNP related association results

Normal genetic study related association results (count: 1)

Reference	Phenotype	Statistical Values	Author Comments	Marker's Category
Solovieff, N.,2014	PTSD severity	P-value=0.304 P-value=0.304	Achieved nominal levels of significance with PTSD severity, ...... Achieved nominal levels of significance with PTSD severity, although was not significant after correction for multiple testing More...	Non-significant

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Association Results (Positive/Negative/Trend)
ADCYAP1R1	adenylate cyclase activating polypeptide 1 (pituitary) receptor type I	7p14.3	19(8/11/0)

SNPs in LD with rs2284225 (count: 8)

The LD data used here is based on 1000 Genome Phase I. LD SNP pairs were selected with a threshold r²<=0.8.


rs_ID	Annotation	No. of Association Results(Positive/Negative/Trend)	r²[population]
rs1541518	downstream_gene_variant(ENST00000409363, ENST00000409489, ENST00000396211, ENST00000436116); 3_prime_UTR_variant(ENST00000614107, ENST00000304166)	1(0/1/0)	0.8385[EUR]

rs_ID	Literature-origin SNPs with LD	Annotation	r²[population]
rs4723047	rs2284225 rs1541518	intron_variant	0.9865[EUR]
rs741057	rs2284225	intron_variant	0.8628[EUR]
rs2284224	rs2284225	intron_variant	0.9468[EUR]
rs2299908	rs2284225	intron_variant	0.9468[EUR]
rs4723045	rs2284225	intron_variant	0.9402[EUR]
rs4723046	rs2284225 rs1541518	intron_variant	0.9933[EUR]
rs6954589	rs2284225	downstream_gene_variant; 3_prime_UTR_variant	0.8005[EUR]

SNP related eQTL (count: 1)

Gene Symbol	Gene Existed in PTSDgene?	Tissue	Trans/Cis	Source
LRRC37A4P	No	Adipose Subcutaneous	cis	GTEx