Gene Report

Basic Info

Approved Symbol	PENK
Approved Name	proenkephalin
Name Alias	preproenkephalin
Location	8q12.1
Position	chr8:56436674-56446734, -1
External Links	HGNC: 8831 Entrez Gene: 5179 Ensembl: ENSG00000181195 UCSC: uc003xsz.2
No. of Association Results	2 (Positive: 1; Negative: 1; trend: 0)
Annotation Type	Literature-origin, Mapped by Literature SNP, Mapped by LD-proxy

Gene related association results

Normal genetic study related association results (count: 2)

Reference	Phenotype	Marker	Gene's Category
Solovieff, N.,2014	PTSD diagnosis	rs2576573	Non-significant
Solovieff, N.,2014	PTSD severity	rs2576573	Significant

Gene functional annotation

Gene related GO terms (count: 36)

ID	Name	Type	Evidence[PMID]	No. of Genes in PTSDgene
GO:0071320	cellular response to cAMP	biological process	IEA	2
GO:0045471	response to ethanol	biological process	IEA	18
GO:0043204	perikaryon	cellular component	IEA	6
GO:0005576	extracellular region	cellular component	TAS	31
GO:0071305	cellular response to vitamin D	biological process	IEA	1
GO:0009314	response to radiation	biological process	IEA	1
GO:0032355	response to estradiol	biological process	IEA	9
GO:0032496	response to lipopolysaccharide	biological process	IEA	9
GO:2000987	positive regulation of behavioral fear response	biological process	IEA	1
GO:0007568	aging	biological process	IEA	11
GO:0001666	response to hypoxia	biological process	IEA	13
GO:0007218	neuropeptide signaling pathway	biological process	IEA	4
GO:0001649	osteoblast differentiation	biological process	IEA	3
GO:0034599	cellular response to oxidative stress	biological process	IEA	2
GO:0032280	symmetric synapse	cellular component	IEA	1
GO:0043278	response to morphine	biological process	IEA	6
GO:0007165	signal transduction	biological process	TAS[7057924]	34
GO:0035641	locomotory exploration behavior	biological process	IEA	1
GO:0071871	response to epinephrine	biological process	IEA	1
GO:0001662	behavioral fear response	biological process	IEA	7
GO:0043679	axon terminus	cellular component	IEA	6
GO:0070852	cell body fiber	cellular component	IEA	4
GO:0051867	general adaptation syndrome, behavioral process	biological process	IEA	1
GO:0009636	response to toxic substance	biological process	IEA	10
GO:0035094	response to nicotine	biological process	IEA	11
GO:0001964	startle response	biological process	IEA	3
GO:0071560	cellular response to transforming growth factor beta stimulus	biological process	IEA	2
GO:0001515	opioid peptide activity	molecular function	IEA	1
GO:0005184	neuropeptide hormone activity	molecular function	TAS[7057924]	4
GO:0005515	protein binding	molecular function	IPI[23597562]	169
GO:0098586	cellular response to virus	biological process	IEA	1
GO:0019233	sensory perception of pain	biological process	IEA	9
GO:0002118	aggressive behavior	biological process	IEA	1
GO:0030425	dendrite	cellular component	IEA	19
GO:0051592	response to calcium ion	biological process	IEA	4
GO:0014009	glial cell proliferation	biological process	IEA	2

Gene related KEGG pathways (count: 0)

Gene related interactors from protein-protein interactions data in PINA v2 (count: 2)

Gene	Interactor	Interactor in PTSDgene?	Experiment Method	Interaction Type	PMID
PENK	UBC	No	--	--	21890473
PENK	OPRM1	No	--	--	23597562 , 23597562 , 23597562