SNP Report

Basic Info

Name	rs17537141 dbSNP Ensembl
Location	4:46300407 - 46300407(+)
Variant Seq	C
Ancestral Allele	T
Ref Seq	T
Minor Allele Frequence	0.0591054
Annotation	downstream_gene_variant; intron_variant; NMD_transcript_variant
Variant Effect	downstream_gene_variant(ENST00000514236); intron_variant(ENST00000630416, ENST00000381620, ENST00000510233, ENST00000510861, ENST00000514090, ENST00000507069, ENST00000540012, ENST00000513005, ENST00000515082, ENST00000356504); NMD_transcript_variant(ENST00000630416, ENST00000510233, ENST00000513005)
SIFT Annotation	tolerated
SIFT Variant Effect	tolerated(ENST00000381620, ENST00000510861, ENST00000540012, ENST00000356504, ENST00000514090, ENST00000507069)
PolyPhen Annotation	unknown; benign
PolyPhen Variant Effect	unknown(ENST00000540012, ENST00000507069); benign(ENST00000381620, ENST00000510861, ENST00000356504, ENST00000514090)
rSNP?	Yes Link in rVarBase
Related Regulatory Elements	n/a
Chromatin State	Weak transcription
No. of Marker's Association Results	1 (Positive: 0; Negative: 1; Trend: 0)
Source	Literature

SNP related association results

Normal genetic study related association results (count: 1)

Reference	Phenotype	Statistical Values	Author Comments	Marker's Category
Solovieff, N.,2014	PTSD severity	P-value=0.303 P-value=0.303	Achieved nominal levels of significance with PTSD severity, ...... Achieved nominal levels of significance with PTSD severity, although was not significant after correction for multiple testing More...	Non-significant

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Association Results (Positive/Negative/Trend)
GABRA2	gamma-aminobutyric acid (GABA) A receptor, alpha 2	4p12	3(1/2/0)

SNPs in LD with rs17537141 (count: 1)

The LD data used here is based on 1000 Genome Phase I. LD SNP pairs were selected with a threshold r²<=0.8.

rs_ID	Literature-origin SNPs with LD	Annotation	r²[population]
rs3775282	rs17537141	intron_variant; NMD_transcript_variant	0.9095[EUR]

SNP related eQTL (count: 1)

Gene Symbol	Gene Existed in PTSDgene?	Tissue	Trans/Cis	Source
CRHR1-IT1	Yes	Adipose Subcutaneous	cis	GTEx