Gene Report

Basic Info

Approved Symbol	CNR1
Previous Symbol	CNR
Symbol Alias	"CB1K5\|CB-R\|CB1\|CANN6\|CB1A"
Approved Name	cannabinoid receptor 1 (brain)
Location	6q14-q15
Position	chr6:88139864-88166359, -1
External Links	HGNC: 2159 Entrez Gene: 1268 Ensembl: ENSG00000118432 UCSC: uc003pmq.4
No. of Association Results	2 (Positive: 0; Negative: 2; trend: 0)
Annotation Type	Literature-origin, Mapped by Literature SNP, Mapped by LD-proxy

Gene related association results

Normal genetic study related association results (count: 2)

Reference	Phenotype	Marker	Gene's Category
Solovieff, N.,2014	PTSD diagnosis	rs806377	Non-significant
Solovieff, N.,2014	PTSD severity	rs7766029	Non-significant

Gene functional annotation

Gene related GO terms (count: 40)

ID	Name	Type	Evidence[PMID]	No. of Genes in PTSDgene
GO:0045759	negative regulation of action potential	biological process	IEA	1
GO:0045777	positive regulation of blood pressure	biological process	IEA	3
GO:0043231	intracellular membrane-bounded organelle	cellular component	IEA	9
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway	biological process	IDA[18761332]	3
GO:0004949	cannabinoid receptor activity	molecular function	IDA[18761332]	1
GO:0005887	integral component of plasma membrane	cellular component	TAS[1718258]	36
GO:0031622	positive regulation of fever generation	biological process	IEA	3
GO:0043278	response to morphine	biological process	IEA	6
GO:0060259	regulation of feeding behavior	biological process	IEA	1
GO:0002866	positive regulation of acute inflammatory response to antigenic stimulus	biological process	IEA	1
GO:0031999	negative regulation of fatty acid beta-oxidation	biological process	IEA	1
GO:0045471	response to ethanol	biological process	IEA	18
GO:0010976	positive regulation of neuron projection development	biological process	IEA	4
GO:0060135	maternal process involved in female pregnancy	biological process	IEA	1
GO:0030424	axon	cellular component	IEA	16
GO:0033602	negative regulation of dopamine secretion	biological process	IEA	2
GO:0032228	regulation of synaptic transmission, GABAergic	biological process	IEA	2
GO:0032496	response to lipopolysaccharide	biological process	IEA	9
GO:0035094	response to nicotine	biological process	IEA	11
GO:0007613	memory	biological process	IEA	11
GO:0045121	membrane raft	cellular component	IEA	7
GO:0043065	positive regulation of apoptotic process	biological process	IEA	12
GO:0030426	growth cone	cellular component	IEA	4
GO:0007568	aging	biological process	IEA	11
GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	biological process	TAS[1718258]	3
GO:0033004	negative regulation of mast cell activation	biological process	IEA	1
GO:0008144	drug binding	molecular function	IEA	13
GO:0019233	sensory perception of pain	biological process	IEA	9
GO:0005886	plasma membrane	cellular component	TAS	99
GO:0051001	negative regulation of nitric-oxide synthase activity	biological process	IEA	2
GO:0051966	regulation of synaptic transmission, glutamatergic	biological process	IEA	1
GO:0042220	response to cocaine	biological process	IEA	7
GO:0038171	cannabinoid signaling pathway	biological process	IDA[18761332]; IEA; TAS[1718258]	1
GO:0042593	glucose homeostasis	biological process	IEA	7
GO:0007283	spermatogenesis	biological process	IEA	7
GO:0007584	response to nutrient	biological process	IEA	5
GO:0045776	negative regulation of blood pressure	biological process	IEA	5
GO:0060405	regulation of penile erection	biological process	IEA	1
GO:0050796	regulation of insulin secretion	biological process	IEA	6
GO:0007413	axonal fasciculation	biological process	IEA	1

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in PTSDgene
hsa04080	Neuroactive ligand-receptor interaction	22

Gene related interactors from protein-protein interactions data in PINA v2 (count: 4)

Gene	Interactor	Interactor in PTSDgene?	Experiment Method	Interaction Type	PMID
CNR1	ADORA2A	No	--	colocalization	17356572 , 17356572 , 17356572
CNR1	GNAI1	No	--	--	11168387 , 11168387
CNR1	RAP1GAP	No	--	--	15657046
CNR1	GNA15	No	--	--	12095632