SNP Report
Basic Info
| Name | rs2746073 dbSNP Ensembl | ||
|---|---|---|---|
| Location | 1:192810097 - 192810097(+) | ||
| Variant Seq | A | ||
| Ancestral Allele | T | ||
| Ref Seq | T | ||
| Minor Allele Frequence | 0.250799 | ||
| Annotation | intron_variant; non_coding_transcript_variant | ||
| Variant Effect | intron_variant(ENST00000483295, ENST00000235382, ENST00000464302, ENST00000487236); non_coding_transcript_variant(ENST00000483295, ENST00000464302, ENST00000487236) | ||
| SIFT Annotation | deleterious | ||
| SIFT Variant Effect | deleterious(ENST00000235382) | ||
| PolyPhen Annotation | probably_damaging | ||
| PolyPhen Variant Effect | probably_damaging(ENST00000235382) | ||
| rSNP? | Yes Link in rVarBase | ||
| Related Regulatory Elements | Chromatin interactive region | ||
| Chromatin State | Active TSS;Enhancers;Weak transcription;Flanking Active TSS;Transcr. at gene 5' nd 3';ZNF genes & repeats;Bivalent Enhancer;Bivalent/Poised TSS | ||
| No. of Marker's Association Results | 1 (Positive: 0; Negative: 1; Trend: 0) | ||
| Source | Literature | ||
SNP related association results
| Reference | Phenotype | Statistical Values | Author Comments | Marker's Category |
|---|---|---|---|---|
| Solovieff, N.,2014 | PTSD severity | P-value=0.355 P-value=0.355 | Achieved nominal levels of significance with PTSD severity, ...... Achieved nominal levels of significance with PTSD severity, although was not significant after correction for multiple testing More... | Non-significant |
SNP related genes (count: 3)
| Approved Symbol | Approved Name | Location | No. of Association Results (Positive/Negative/Trend)  |
|---|---|---|---|
| CDC73 | cell division cycle 73 | 1q25 | rSNP target |
| UCHL5 | ubiquitin C-terminal hydrolase L5 | 1q32 | rSNP target |
| RGS2 | regulator of G-protein signaling 2 | 1q31 | 7(2/5/0) |
SNPs in LD with rs2746073 (count: 23)
Literature-origin SNPs (count: 1)
LD-proxies (count: 22)
SNP related eQTL (count: 1)