PTSDgene database

SNP Report

Basic Info
Name rs2746073 dbSNP Ensembl
Location 1:192810097 - 192810097(+)
Variant Seq A
Ancestral Allele T
Ref Seq T
Minor Allele Frequence 0.250799
Annotation intron_variant; non_coding_transcript_variant
Variant Effect intron_variant(ENST00000483295, ENST00000235382, ENST00000464302, ENST00000487236); non_coding_transcript_variant(ENST00000483295, ENST00000464302, ENST00000487236)
SIFT Annotation deleterious
SIFT Variant Effect deleterious(ENST00000235382)
PolyPhen Annotation probably_damaging
PolyPhen Variant Effect probably_damaging(ENST00000235382)
rSNP? Yes Link in rVarBase
Related Regulatory Elements Chromatin interactive region
Chromatin State Active TSS;Enhancers;Weak transcription;Flanking Active TSS;Transcr. at gene 5' nd 3';ZNF genes & repeats;Bivalent Enhancer;Bivalent/Poised TSS
No. of Marker's Association Results 1 (Positive: 0; Negative: 1; Trend: 0)
Source Literature

SNP related association results
Normal genetic study related association results (count: 1)
Reference Phenotype Statistical Values Author Comments Marker's Category
Solovieff, N.,2014 PTSD severity P-value=0.355 P-value=0.355 Achieved nominal levels of significance with PTSD severity, ...... Achieved nominal levels of significance with PTSD severity, although was not significant after correction for multiple testing More... Non-significant

SNP related genes (count: 3)
Approved Symbol Approved Name Location No. of Association Results (Positive/Negative/Trend)
CDC73 cell division cycle 73 1q25 rSNP target
UCHL5 ubiquitin C-terminal hydrolase L5 1q32 rSNP target
RGS2 regulator of G-protein signaling 2 1q31 7(2/5/0)

SNPs in LD with rs2746073 (count: 23)
The LD data used here is based on 1000 Genome Phase I. LD SNP pairs were selected with a threshold r2<=0.8.

Literature-origin SNPs (count: 1)

LD-proxies (count: 22)

SNP related eQTL (count: 1)
Gene Symbol Gene Existed in PTSDgene? Tissue Trans/Cis Source
WNT3 No Adipose Subcutaneous cis GTEx