PTSDgene database

SNP Report

Basic Info
Name rs17110747 dbSNP Ensembl
Location 12:72032174 - 72032174(+)
Variant Seq A
Ancestral Allele G
Ref Seq G
Minor Allele Frequence 0.145367
Annotation 3_prime_UTR_variant; intron_variant; non_coding_transcript_variant
Variant Effect 3_prime_UTR_variant(ENST00000333850); intron_variant(ENST00000550403, ENST00000547348, ENST00000551074, ENST00000547278); non_coding_transcript_variant(ENST00000550403, ENST00000547348, ENST00000551074, ENST00000547278)
SIFT Annotation deleterious
SIFT Variant Effect deleterious(ENST00000333850)
PolyPhen Annotation possibly_damaging
PolyPhen Variant Effect possibly_damaging(ENST00000333850)
rSNP? Yes Link in rVarBase
Related Regulatory Elements n/a
Chromatin State Weak transcription;Enhancers
No. of Marker's Association Results 2 (Positive: 0; Negative: 2; Trend: 0)
Source Literature

SNP related association results
Normal genetic study related association results (count: 2)
Reference Phenotype Statistical Values Author Comments Marker's Category
Solovieff, N.,2014 PTSD diagnosis P-value=0.163 P-value=0.163 Achieved nominal levels of significance with PTSD diagnosis,...... Achieved nominal levels of significance with PTSD diagnosis, although was not significant after correction for multiple testing More... Non-significant
Goenjian, A. K.,2012 PTSD-RI (PTSD symptoms) After adjusting for age, sex, exposure and environmental var...... After adjusting for age, sex, exposure and environmental variables, analyses of PTSD-RI and this SNP: P-value>0.05. More... The remainder of the TPH2 SNPs tested did not show a signifi...... The remainder of the TPH2 SNPs tested did not show a significant association with PTSD-RI scores; and the linkage scores were below 1.0. More... Non-significant


SNP related genes (count: 1)
Approved Symbol Approved Name Location No. of Association Results (Positive/Negative/Trend)
TPH2 tryptophan hydroxylase 2 12q15 10(3/7/0)

SNPs in LD with rs17110747 (count: 3)
The LD data used here is based on 1000 Genome Phase I. LD SNP pairs were selected with a threshold r2<=0.8.

Literature-origin SNPs (count: 0)

LD-proxies (count: 3)


SNP related eQTL (count: 1)
Gene Symbol Gene Existed in PTSDgene? Tissue Trans/Cis Source
RP11-707O23.5 No Adipose Subcutaneous cis GTEx