PTSDgene database

SNP Report

Basic Info
Name rs2766581 dbSNP Ensembl
Location 6:35782522 - 35782522(+)
Variant Seq G
Ancestral Allele A
Ref Seq A
Minor Allele Frequence 0.249201
Annotation downstream_gene_variant; upstream_gene_variant; intron_variant
Variant Effect downstream_gene_variant(ENST00000403376, ENST00000360454, ENST00000481904, ENST00000467122); upstream_gene_variant(ENST00000428710); intron_variant(ENST00000373861)
SIFT Annotation tolerated_-_low_confidence; tolerated
SIFT Variant Effect tolerated_-_low_confidence(ENST00000360454); tolerated(ENST00000403376)
PolyPhen Annotation probably_damaging; possibly_damaging
PolyPhen Variant Effect probably_damaging(ENST00000403376); possibly_damaging(ENST00000360454)
rSNP? Yes Link in rVarBase
Related Regulatory Elements TF binding region;Chromatin interactive region
Chromatin State Enhancers;Weak transcription
No. of Marker's Association Results 1 (Positive: 0; Negative: 1; Trend: 0)
Source Literature

SNP related association results
Normal genetic study related association results (count: 1)
Reference Phenotype Statistical Values Author Comments Marker's Category
Solovieff, N.,2014 PTSD diagnosis P-value=0.041 P-value=0.041 Achieved nominal levels of significance with PTSD diagnosis,...... Achieved nominal levels of significance with PTSD diagnosis, although was not significant after correction for multiple testing More... Non-significant

SNP related genes (count: 3)
Approved Symbol Approved Name Location No. of Association Results (Positive/Negative/Trend)
CLPSL1 colipase like 1 6p21.31 Mapped by Literature SNP, Mapped by LD-proxy
CLPSL2 colipase like 2 6p21.31 Mapped by Literature SNP, Mapped by LD-proxy
FKBP5 FK506 binding protein 5 6p21.31 25(12/13/0)

SNPs in LD with rs2766581 (count: 6)
The LD data used here is based on 1000 Genome Phase I. LD SNP pairs were selected with a threshold r2<=0.8.

Literature-origin SNPs (count: 0)

LD-proxies (count: 6)

SNP related eQTL (count: 1)
Gene Symbol Gene Existed in PTSDgene? Tissue Trans/Cis Source
CRHR1 Yes Adipose Subcutaneous cis GTEx