PTSDgene database

SNP Report

Basic Info
Name rs806377 dbSNP Ensembl
Location 6:88149004 - 88149004(+)
Variant Seq C
Ancestral Allele C
Ref Seq T
Minor Allele Frequence 0.490216
Annotation upstream_gene_variant; intron_variant
Variant Effect upstream_gene_variant(ENST00000362094, ENST00000468898, ENST00000549890); intron_variant(ENST00000428600, ENST00000369499, ENST00000551417, ENST00000369501)
SIFT Annotation deleterious_-_low_confidence; tolerated_-_low_confidence; deleterious
SIFT Variant Effect deleterious_-_low_confidence(ENST00000362094, ENST00000468898); tolerated_-_low_confidence(ENST00000549890, ENST00000369501, ENST00000428600, ENST00000369499); deleterious(ENST00000551417)
PolyPhen Annotation benign; probably_damaging
PolyPhen Variant Effect benign(ENST00000551417, ENST00000549890, ENST00000369501, ENST00000428600, ENST00000369499); probably_damaging(ENST00000362094, ENST00000468898)
rSNP? Yes Link in rVarBase
Related Regulatory Elements n/a
Chromatin State Weak transcription;Enhancers
No. of Marker's Association Results 1 (Positive: 0; Negative: 1; Trend: 0)
Source Literature

SNP related association results
Normal genetic study related association results (count: 1)
Reference Phenotype Statistical Values Author Comments Marker's Category
Solovieff, N.,2014 PTSD diagnosis P-value=0.125 P-value=0.125 Achieved nominal levels of significance with PTSD diagnosis,...... Achieved nominal levels of significance with PTSD diagnosis, although was not significant after correction for multiple testing More... Non-significant

SNP related genes (count: 1)
Approved Symbol Approved Name Location No. of Association Results (Positive/Negative/Trend)
CNR1 cannabinoid receptor 1 (brain) 6q14-q15 2(0/2/0)

SNPs in LD with rs806377 (count: 2)
The LD data used here is based on 1000 Genome Phase I. LD SNP pairs were selected with a threshold r2<=0.8.

Literature-origin SNPs (count: 0)

LD-proxies (count: 2)

SNP related eQTL (count: 1)
Gene Symbol Gene Existed in PTSDgene? Tissue Trans/Cis Source
CRHR1 Yes Adipose Subcutaneous cis GTEx