SNP Report

Basic Info

Name	rs806377 dbSNP Ensembl
Location	6:88149004 - 88149004(+)
Variant Seq	C
Ancestral Allele	C
Ref Seq	T
Minor Allele Frequence	0.490216
Annotation	upstream_gene_variant; intron_variant
Variant Effect	upstream_gene_variant(ENST00000362094, ENST00000468898, ENST00000549890); intron_variant(ENST00000428600, ENST00000369499, ENST00000551417, ENST00000369501)
SIFT Annotation	deleterious_-_low_confidence; tolerated_-_low_confidence; deleterious
SIFT Variant Effect	deleterious_-_low_confidence(ENST00000362094, ENST00000468898); tolerated_-_low_confidence(ENST00000549890, ENST00000369501, ENST00000428600, ENST00000369499); deleterious(ENST00000551417)
PolyPhen Annotation	benign; probably_damaging
PolyPhen Variant Effect	benign(ENST00000551417, ENST00000549890, ENST00000369501, ENST00000428600, ENST00000369499); probably_damaging(ENST00000362094, ENST00000468898)
rSNP?	Yes Link in rVarBase
Related Regulatory Elements	n/a
Chromatin State	Weak transcription;Enhancers
No. of Marker's Association Results	1 (Positive: 0; Negative: 1; Trend: 0)
Source	Literature

SNP related association results

Normal genetic study related association results (count: 1)

Reference	Phenotype	Statistical Values	Author Comments	Marker's Category
Solovieff, N.,2014	PTSD diagnosis	P-value=0.125 P-value=0.125	Achieved nominal levels of significance with PTSD diagnosis,...... Achieved nominal levels of significance with PTSD diagnosis, although was not significant after correction for multiple testing More...	Non-significant

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Association Results (Positive/Negative/Trend)
CNR1	cannabinoid receptor 1 (brain)	6q14-q15	2(0/2/0)

SNPs in LD with rs806377 (count: 2)

The LD data used here is based on 1000 Genome Phase I. LD SNP pairs were selected with a threshold r²<=0.8.

rs_ID	Literature-origin SNPs with LD	Annotation	r²[population]
rs806379	rs806377	intron_variant	0.8395[EUR]
rs806376	rs806377	upstream_gene_variant; intron_variant	0.8901[EUR]

SNP related eQTL (count: 1)

Gene Symbol	Gene Existed in PTSDgene?	Tissue	Trans/Cis	Source
CRHR1	Yes	Adipose Subcutaneous	cis	GTEx