SNP Report
Basic Info
| Name | rs1876831 dbSNP Ensembl | ||
|---|---|---|---|
| Location | 17:45830379 - 45830379(+) | ||
| Variant Seq | T | ||
| Ancestral Allele | C | ||
| Ref Seq | C | ||
| Minor Allele Frequence | 0.0860623 | ||
| Annotation | downstream_gene_variant; non_coding_transcript_exon_variant; upstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_variant | ||
| Variant Effect | downstream_gene_variant(ENST00000580955); non_coding_transcript_exon_variant(ENST00000582766); upstream_gene_variant(ENST00000581479, ENST00000580876, ENST00000535778); intron_variant(ENST00000314537, ENST00000352855, ENST00000347197, ENST00000339069, ENST00000634540, ENST00000583888, ENST00000293493, ENST00000619154, ENST00000398285, ENST00000577353, ENST00000634876); NMD_transcript_variant(ENST00000347197, ENST00000583888); non_coding_transcript_variant(ENST00000582766, ENST00000634876) | ||
| SIFT Annotation | deleterious_-_low_confidence | ||
| SIFT Variant Effect | deleterious_-_low_confidence(ENST00000619154) | ||
| PolyPhen Annotation | unknown | ||
| PolyPhen Variant Effect | unknown(ENST00000619154) | ||
| rSNP? | Yes Link in rVarBase | ||
| Related Regulatory Elements | n/a | ||
| Chromatin State | Weak transcription | ||
| No. of Marker's Association Results | 1 (Positive: 0; Negative: 1; Trend: 0) | ||
| Source | Literature | ||
SNP related association results
| Reference | Phenotype | Statistical Values | Author Comments | Marker's Category |
|---|---|---|---|---|
| Davydow, D. S.,2014 | Post-ICU PTSD | CRHR1 (rs1876831) C allele with post-ICU PTSD symptoms, C/T ...... CRHR1 (rs1876831) C allele with post-ICU PTSD symptoms, C/T heterozygotes: beta=3.2, 95%CI=?9.8, 16.1; P-value=0.63; C/C homozygotes: beta=?0.8, 95%CI=?13.4, 11.8, P-value=0.90. More... | Carrying a CRHR1 (rs1876831) C allele was not associated wit...... Carrying a CRHR1 (rs1876831) C allele was not associated with post-ICU PTSD symptoms. After Bonferroni correction, the associations of homozygosity for the CRHBP (rs10055255) T allele with fewer post-ICU depressive symptoms and heterozygosity or homozygosity for the CRHR1 (rs1876831) C allele no longer met the threshold for statistical significance. More... | Non-significant |
SNP related genes (count: 2)
| Approved Symbol | Approved Name | Location | No. of Association Results (Positive/Negative/Trend)  |
|---|---|---|---|
| CRHR1 | corticotropin releasing hormone receptor 1 | 17q21.31 | 12(6/6/0) |
| MAPT-AS1 | MAPT antisense RNA 1 | 17q21.31 | Mapped by Literature SNP, Mapped by LD-proxy, rSNP target |
SNPs in LD with rs1876831 (count: 909)
