PTSDgene database

SNP Report

Basic Info
Name rs1876831 dbSNP Ensembl
Location 17:45830379 - 45830379(+)
Variant Seq T
Ancestral Allele C
Ref Seq C
Minor Allele Frequence 0.0860623
Annotation downstream_gene_variant; non_coding_transcript_exon_variant; upstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_variant
Variant Effect downstream_gene_variant(ENST00000580955); non_coding_transcript_exon_variant(ENST00000582766); upstream_gene_variant(ENST00000581479, ENST00000580876, ENST00000535778); intron_variant(ENST00000314537, ENST00000352855, ENST00000347197, ENST00000339069, ENST00000634540, ENST00000583888, ENST00000293493, ENST00000619154, ENST00000398285, ENST00000577353, ENST00000634876); NMD_transcript_variant(ENST00000347197, ENST00000583888); non_coding_transcript_variant(ENST00000582766, ENST00000634876)
SIFT Annotation deleterious_-_low_confidence
SIFT Variant Effect deleterious_-_low_confidence(ENST00000619154)
PolyPhen Annotation unknown
PolyPhen Variant Effect unknown(ENST00000619154)
rSNP? Yes Link in rVarBase
Related Regulatory Elements n/a
Chromatin State Weak transcription
No. of Marker's Association Results 1 (Positive: 0; Negative: 1; Trend: 0)
Source Literature

SNP related association results
Normal genetic study related association results (count: 1)
Reference Phenotype Statistical Values Author Comments Marker's Category
Davydow, D. S.,2014 Post-ICU PTSD CRHR1 (rs1876831) C allele with post-ICU PTSD symptoms, C/T ...... CRHR1 (rs1876831) C allele with post-ICU PTSD symptoms, C/T heterozygotes: beta=3.2, 95%CI=?9.8, 16.1; P-value=0.63; C/C homozygotes: beta=?0.8, 95%CI=?13.4, 11.8, P-value=0.90. More... Carrying a CRHR1 (rs1876831) C allele was not associated wit...... Carrying a CRHR1 (rs1876831) C allele was not associated with post-ICU PTSD symptoms. After Bonferroni correction, the associations of homozygosity for the CRHBP (rs10055255) T allele with fewer post-ICU depressive symptoms and heterozygosity or homozygosity for the CRHR1 (rs1876831) C allele no longer met the threshold for statistical significance. More... Non-significant

SNP related genes (count: 2)
Approved Symbol Approved Name Location No. of Association Results (Positive/Negative/Trend)
CRHR1 corticotropin releasing hormone receptor 1 17q21.31 12(6/6/0)
MAPT-AS1 MAPT antisense RNA 1 17q21.31 Mapped by Literature SNP, Mapped by LD-proxy, rSNP target

SNPs in LD with rs1876831 (count: 909)
The LD data used here is based on 1000 Genome Phase I. LD SNP pairs were selected with a threshold r2<=0.8.

Literature-origin SNPs (count: 1)

LD-proxies (count: 908)