PTSDgene database

Study Report

Study Information
Basic Info
Reference
Citation Davydow, D. S., et al. (2014). "A pilot investigation of the association of genetic polymorphisms regulating corticotrophin-releasing hormone with posttraumatic stress and depressive symptoms in medical-surgical intensive care unit survivors." J Crit Care 29(1): 101-106.
Phenotype Post-ICU PTSD
Trauma Medical-surgical intensive care unit (ICU) hospitalization
Study Design Longitudinal pilot design
Study Type Candidate gene association study
Sample Size 93 ICU patients
SNP/Marker Size 2 SNPs
Predominant Ethnicity Caucasian
Population 25 Non-White
Gender 53 males, 40 females
Age Median age was 50.0 (IQR: 37.5, 58.0)

Detail Info

Genetic result reported by this study
Normal genetic result reported by this study (count: 2)
Marker Phenotype Related Gene Statistical Values Author Comments Marker's Category
rs10055255 Post-ICU PTSD CRHBP In unadjusted analyses, being homozygous for the CRHBP (rs10055255) T allele with post-ICU PTSD: beta=?10.8, 95%CI=?17.7, ?3.9; P-value= 0.002. In unadjusted analyses, being homozygous for the CRHBP (rs10...... In unadjusted analyses, being homozygous for the CRHBP (rs10055255) T allele was associated with significantly fewer post-ICU PTSD. The unadjusted associations we found remained significant in our fully adjusted regression models that controlled for age, race, SAPS II score at ICU admission, and in-ICU corticosteroid exposure. After Bonferroni correction, the association of homozygosity for the CRHBP (rs10055255) T allele with fewer post-ICU PTSD symptoms continued to meet the threshold for statistical significance. More... Significant
rs1876831 Post-ICU PTSD CRHR1 CRHR1 (rs1876831) C allele with post-ICU PTSD symptoms, C/T heterozygotes: beta=3.2, 95%CI=?9.8, 16.1; P-value=0.63; C/C homozygotes: beta=?0.8, 95%CI=?13.4, 11.8, P-value=0.90. Carrying a CRHR1 (rs1876831) C allele was not associated wit...... Carrying a CRHR1 (rs1876831) C allele was not associated with post-ICU PTSD symptoms. After Bonferroni correction, the associations of homozygosity for the CRHBP (rs10055255) T allele with fewer post-ICU depressive symptoms and heterozygosity or homozygosity for the CRHR1 (rs1876831) C allele no longer met the threshold for statistical significance. More... Non-significant