Study Report
Study Information
Basic Info
| Reference |
Lee, H. J.,2005 PMID: 15965993
|
| Citation |
Lee, H. J., et al. (2005). "Influence of the serotonin transporter promoter gene polymorphism on susceptibility to posttraumatic stress disorder." Depress Anxiety 21(3): 135-139. |
| Phenotype |
PTSD diagnosis |
| Trauma |
Various |
| Study Design |
Case-control |
| Study Type |
Candidate gene association study |
| Sample Size |
100 cases, 197 controls |
| SNP/Marker Size |
1 Variant |
| Predominant Ethnicity |
Mongloid |
| Population |
Korean |
| Gender |
Case: 57 females, 43 males. Control: 121 females, 76 males |
| Age |
Case: mean age=35.29 years, SD=10.29; control: mean age=34.76 years, SD=11.06 |
Detail Info
| Sample Diagnosis |
DSM-IV |
| Related Diagnostic Tools |
Trained psychiatrists examined all subjects using the Structured Clinical Interview for DSM-IV-Korean version. |
| Sample Status |
A total of 224 physically healthy participants were interviewed by trained psychiatrists and were ascertained to be free of major psychiatric problems. Patients with a history of alcohol or drug dependence, neurological disorders, or any concomitant DSM-IV Axis I and prominent Axis II psychiatric disorders were excluded.Patients who had suffered from major depression before the traumatic event also were excluded. |
| Controls Exposed |
NS |
| Replication Size |
None |
| Result Summary |
The frequency of the s/s genotype was significantly higher in PTSD patients than in normal controls. These findings suggest that the SERTPR s/s genotype is one of the genetic factors for the susceptibility to PTSD. |
| Potential Biomarker |
None |
Genetic result reported by this study
Normal genetic result reported by this study (count: 1)
| Marker |
Phenotype |
Related Gene |
Statistical Values |
Author Comments |
Marker's Category |
|
SERTPR
|
PTSD diagnosis |
SLC6A4 |
Genotypes: X2=4.18, P-value=0.124; allele: X2=4.05, P-value=0.044, OR=1.65, 95%CI: 1.01-2.68. When the genotypes of SERTPR were dichotomized into s/s and l/s+l/l groups, X2=4.14, P-value=0.042, OR=1.77, 95%CI: 1.02-3.06. |
There were marginal differences in genotypes between the two......
There were marginal differences in genotypes between the two groups, and the allele frequency was significantly different, when the genotype of SERTPR were dichotomized into s/s and l/s+l/l groups, the frequency of the s/s genotype was significantly higher in patients with PTSD.
More...
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Significant |
