PTSDgene database

Study Report

Study Information
Basic Info
Reference
Citation Kimbrel, N. A., et al. (2015). "Effect of the 5-HTTLPR polymorphism on posttraumatic stress disorder, depression, anxiety, and quality of life among Iraq and Afghanistan veterans." Anxiety Stress Coping 28(4): 456-466.
Phenotype PCL-M scores, QOLS scores
Trauma Iraq/Afghanistan-era war
Study Design Case-control
Study Type Candidate gene association study
Sample Size 186 Iraq and Afghanistan war veterans
SNP/Marker Size 1 Variant
Predominant Ethnicity Caucasian
Population Predominantly white (62%; n=116)
Gender 159 males
Age Ranged from 22 to 63 years (mean age=38.6 years, SD=10.6).

Detail Info

Genetic result reported by this study
Normal genetic result reported by this study (count: 2)
Marker Phenotype Related Gene Statistical Values Author Comments Marker's Category
5-HTTLPR PCL-M scores SLC6A4 Univariate effects for the 5-HTTLPR polymorphism on PTSD: in total sample, P-value=0.002; in European Ancestry only, P-value<0.001. Significant (P-value < .0083) univariate effects for the 5-H...... Significant (P-value < .0083) univariate effects for the 5-HTTLPR polymorphism were observed on the PCL-M (small effect). Notably, the effect of 5-HTTLPR polymorphism on post-deployment adjustment among individuals of European ancestry was larger than the effect observed in the overall sample. More... Significant
5-HTTLPR QOLS scores SLC6A4 Univariate effects for the 5-HTTLPR polymorphism on QOLS scores: in total sample, P-value=0.001; in European Ancestry only, P-value<0.001. Significant (P-value < .0083) univariate effects for the 5-H...... Significant (P-value < .0083) univariate effects for the 5-HTTLPR polymorphism were observed on QOLS (medium effect). Notably, the effect of 5-HTTLPR polymorphism on post-deployment adjustment among individuals of European ancestry was larger than the effect observed in the overall sample. More... Significant