PTSDgene database

Meta-analysis Report

Basic Info
Reference
Citation Navarro-Mateu, F., et al. (2013). "Meta-analyses of the 5-HTTLPR polymorphisms and post-traumatic stress disorder." PLoS One 8(6): e66227.
Objective To conduct a meta-analysis of all published genetic association studies of 5-HTTLPR polymorphisms performed in PTSD cases.
Study Type Candidate gene association study,Gene-Environmental interaction study
Extract Database PubMed/MEDLINE, EMBASE, Web of Science databases (Web of Knowledge, WoK), PsychINFO, PsychArticles and HuGeNet (Human Genome Epidemiology Network)
Time Range up until December 2011

Detail Info

Genetic result reported by this study
Normal genetic result reported by this study (count: 1)
Marker Phenotype Related Gene Statistical Values Author Comments Marker's Category
5-HTTLPR PTSD SLC6A4 S allele vs L allele: OR=1.05; 95% CI=0.87, 1.26; P-value=0.63; I2=63; the dominant model,BDM (S+vs LL)OR=1.01;95% CI=0.78, 1.30; P-value=0.95; I2=57; the recessive model, BRM (SS vs L+) OR=1.15; 95%CI=0.82, 1.60; P-value=0.41; I2=55, respectively) (Figs 2, 3 and 4).Secondly, a meta-analysis of the triallelic approach offered similar results for the TFM model (OR=1.15; 95%CI=0.82,1.60; P-value=0.41; I2=74), for TDM model (OR=1.02; 95%CI=0.73, 1.48; P-value=0.93; I2= 43) and for the TRM (OR=1.31; 95%CI=71, 2.41; P-value=0.38; I2=80) (Figs 5, 6 and 7, respectively).0.66, 1.74; I2=78% and TFM, OR=1.14; 95% CI: 0.70, 1.87; I2=81%), in the dominant model (BDM, OR=1.09; 95% CI: 0.61, 1.96; I2=72%, TDM, OR=0.93; 95% CI: 0.60, 1.44; I2=39%) and in the recessive model (BRM, OR=1.05; 95% CI: 0.41, 2.67; I2=73%, TRM, OR=1.40; 95% CI: 0.54, 3.57;I2=85%). This is the first published meta-analysis of the relationshi...... This is the first published meta-analysis of the relationship between 5-HTTLPR polymorphisms and PTSD. They found no significant relationship between biallelic or triallelic polymorphism and PTSD, using the three possible approaches (allele frequency, dominant and recessive model). More... Non-significant