Study Report
Study Information
Basic Info
| Reference |
Wang, Z.,2011 PMID: 21818827
|
| Citation |
Wang, Z., et al. (2011). "The relationship between combat-related posttraumatic stress disorder and the 5-HTTLPR/rs25531 polymorphism." Depress Anxiety 28(12): 1067-1073. |
| Phenotype |
PTSD status, CAPS score, PTSD severity |
| Trauma |
Combat |
| Study Design |
Case-control |
| Study Type |
Candidate gene association study |
| Sample Size |
212 cases, 176 controls |
| SNP/Marker Size |
1 Variant |
| Predominant Ethnicity |
Caucasian, Black |
| Population |
Case: 149 European Americans, 50 African Americans, 13 others; Control: 131 European Americans, 41 African Americans, 4 others |
| Gender |
Case: 185 males, 27 females, Control: 154 males and 22 females |
| Age |
Case: mean age=48.7 years,SD=14.47, Control: mean age=49.5 years,SD=13.85 |
Detail Info
| Sample Diagnosis |
DSM-IV |
| Related Diagnostic Tools |
Structured Clinical Interview for DSM-IV (SCIDA), MiniInternational Neuropsychiatric Interview (MINI), Clinician Administered PTSD Scale (CAPS), Combat Exposure Scale (CES), after collecting the demographic and deployment information, the participants were assessed by a trained research assistant for the presence of PTSD or other psychiatric disorders. A board-certified psychiatrist interviewed participants for combat exposure history and PTSD status. |
| Sample Status |
For those with PTSD, 61%, n =129 met criteria for comorbid major depressive disorder and 30%, n =64 met criteria for comorbid substance abuse. Subjects with current or lifetime DSM-IV schizophrenia, other psychotic disorders, bipolar disorder, and active substance abuse or dependence in the past six months were excluded. Control subjects were free of Axis I psychiatric disorders. |
| Controls Exposed |
Yes |
| Replication Size |
None |
| Result Summary |
There were significant intergroup (PTSD versus non-PTSD) differences in the genotype frequencies of 5-HTTLPR/rs25531 (X2=16.23, P-value=5.62E-05). The 5HTTLPR S'/S' (low transcriptionally efficient) genotype was also associated with the PTSD severity score in the 228 participants who had combat severity data (r=0.15, P-value=0.03). In summary, this study showed a significant association between the specific 5-HTTLPR/ rs25531 genotype and PTSD. The triallelic polymorphism was highly correlated with PTSD severity. Despite the limitations of this study, our data do suggest that the low expressing 5HTTLPR variant is a significant genetic risk factor for PTSD development after severe trauma exposure. |
| Potential Biomarker |
None |
Genetic result reported by this study
Normal genetic result reported by this study (count: 3)
| Marker |
Phenotype |
Related Gene |
Statistical Values |
Author Comments |
Marker's Category |
|
5-HTTLPR
|
PTSD severity |
SLC6A4 |
OR=1.77, 95%CI: 1.33-2.35, P-value=0.000102 |
The S' allele predicted the PTSD severity score.
The S' allele predicted the PTSD severity score.
|
Significant |
|
5-HTTLPR
|
PTSD status |
SLC6A4 |
Whole sample: Chi-square linear-by-linear association test: X2=16.23, P-value=5.62E-05. After controlling for demographic variables: OR=1.77. Caucasian subsample: OR= 1.92 |
There is a significant association between the 5HTTLPR polym......
There is a significant association between the 5HTTLPR polymorphism and PTSD status, reflecting the higher prevalence of the S'/S' genotype in cases (45%) versus controls (17%). The S' allele of the 5HTTLPR remained significantly associated with increased likelihood of having PTSD after controlling for demographic variables. When selecting the subset of participants who were Caucasian ( n =271), results were similar to those of the full sample, with the S' allele being associated with PTSD.
More...
|
Significant |
|
5-HTTLPR
|
CAPS score |
SLC6A4 |
R=0.15, P-value=0.03 |
The correlation between the 5-HTTLPR and the CAPS score was ......
The correlation between the 5-HTTLPR and the CAPS score was significant.
More...
|
Significant |
