Gressier, F.,2013 PMID: 24222274
||Gressier, F., et al. (2013). "The 5-HTTLPR polymorphism and posttraumatic stress disorder: a meta-analysis." J Trauma Stress 26(6): 645-653.
||Environmental and genetic factors contribute to the development of posttraumatic stress disorder (PTSD). Variation in the 5-HTTLPR polymorphism of the serotonin transporter gene has been hypothesized to affect risk for PTSD. With the aim of investigating this association, we conducted a meta-analysis to shed light on prior controversial results and increase statistical power to detect smaller effect sizes.
||Candidate gene association study
||PubMed and ISI databases
||until December 2012
Genetic result reported by this study
Normal genetic result reported by this study (count: 1)
||Association between PTSD and SS genotype: z=1.64, P-value=.10, heterogeneity: X2=40.59, P-value<.001, I2=73. An analysis grouping SS and SL versus LL participants and considering allele frequencies (S vs. L), odds ratio (OR)=0.88, 95%CI=0.67-1.15, z=0.94, P-value=.35; and OR=1.08, 95%CI=0.88-1.32, z=0.72, P-value=.47; heterogeneity: X2= 21.39, P-value=.03, I2= 49, and X2= 28.94, P-value=.002, I2= 62, respectively.
Random effects indicated no association between PTSD and SS ......
Random effects indicated no association between PTSD and SS genotype. However, there was evidence of high between-study heterogeneity. Egger's test indicated no evidence of publication bias. We explored gender and age as covariates with meta-regression, and found a gender-dependent association, but no influence of age. Consequently, gender explained part of the heterogeneity between studies. We also performed an analysis grouping SS and SL versus LL participants and considering allele frequencies (S vs. L). In both cases no association was found and a high between-study heterogeneity was identified.