Mellman, T. A.,2009 PMID: 19842167
||Mellman, T. A., et al. (2009). "Serotonin polymorphisms and posttraumatic stress disorder in a trauma exposed African American population." Depress Anxiety 26(11): 993-997.
||Candidate gene association study
||55 cases, 63 controls
||1 SNP, 1 Variant
||Case: 12 males and 43 females, Control: 28 males and 35 females
||Case: mean age=39.5 years,SD=15.8, Control: mean age=40.3 years,SD=16.8
Genetic result reported by this study
Normal genetic result reported by this study (count: 2)
||Chi-square test: X2=9.8, P-value= 0.008. Regression model: OR= 2.7, 95% CI= 1.3-5.6, P-value= 0.006.
There was a significant association of PTSD with 5HT2A genot......
There was a significant association of PTSD with 5HT2A genotypes. The regression model revealed a significant association of the G allele with PTSD.
||Chi-square test: X2=1.0. Regression model: OR= 1.3, 95% CI= 0.8-2.3
PTSD was not significantly associated with 5HTTLPR functiona......
PTSD was not significantly associated with 5HTTLPR functional genotypes. The relationship of 5HTTLPR LE alleles to PTSD was not significant.