Study Report
Study Information
Basic Info
| Reference |
Mellman, T. A.,2009 PMID: 19842167
|
| Citation |
Mellman, T. A., et al. (2009). "Serotonin polymorphisms and posttraumatic stress disorder in a trauma exposed African American population." Depress Anxiety 26(11): 993-997. |
| Phenotype |
PTSD |
| Trauma |
Various |
| Study Design |
Case-control |
| Study Type |
Candidate gene association study |
| Sample Size |
55 cases, 63 controls |
| SNP/Marker Size |
1 SNP, 1 Variant |
| Predominant Ethnicity |
Black |
| Population |
African American |
| Gender |
Case: 12 males and 43 females, Control: 28 males and 35 females |
| Age |
Case: mean age=39.5 years,SD=15.8, Control: mean age=40.3 years,SD=16.8 |
Detail Info
| Sample Diagnosis |
DSM-IV |
| Related Diagnostic Tools |
Clinician Assessed PTSD Scale (CAPS), Structured Clinical Interview for DSM-IV (SCID) |
| Sample Status |
This study analyses excluded participants who met criteria for psychotic and bipolar disorders, or current alcohol and substance dependence. |
| Controls Exposed |
NS |
| Replication Size |
None |
| Result Summary |
The 5HT2A (lower expressing) G allele was significantly associated with PTSD. We did not find significant associations with 5HTTLPR. Our findings suggest a relationship between genetic variation in the 5HT2A promoter region and PTSD. |
| Potential Biomarker |
None |
Genetic result reported by this study
Normal genetic result reported by this study (count: 2)
| Marker |
Phenotype |
Related Gene |
Statistical Values |
Author Comments |
Marker's Category |
|
rs6311
|
PTSD |
HTR2A |
Chi-square test: X2=9.8, P-value= 0.008. Regression model: OR= 2.7, 95% CI= 1.3-5.6, P-value= 0.006. |
There was a significant association of PTSD with 5HT2A genot......
There was a significant association of PTSD with 5HT2A genotypes. The regression model revealed a significant association of the G allele with PTSD.
More...
|
Significant |
|
5-HTTLPR
|
PTSD |
SLC6A4 |
Chi-square test: X2=1.0. Regression model: OR= 1.3, 95% CI= 0.8-2.3 |
PTSD was not significantly associated with 5HTTLPR functiona......
PTSD was not significantly associated with 5HTTLPR functional genotypes. The relationship of 5HTTLPR LE alleles to PTSD was not significant.
More...
|
Non-significant |
