Variant Report
Basic Info
| Name | 5-HTTLPR |
|---|---|
| Type | Microsatellite |
| Location | promoter (5' flanking regulatory region) |
| Related Gene | SLC6A4 |
| No. of Association Result | 39 (Positive: 11; Negative: 28; Trend: 0) |
Variant related studies
Normal genetic study related association result (count: 39)
| Reference | Phenotype | Statistical Values | Author Comments | Marker's Category |
|---|---|---|---|---|
| Kovacic Petrovic, Z.,2016 | PTSD severity | X2=11.04, df=5, P-value=0.051 X2=11.04, df=5, P-value=0.051 | No significant association was found between the severity of...... No significant association was found between the severity of PTSD symptoms and 5-HTTLPR genotype. More... | Non-significant |
| Thakur, G. A., 2009 | Acute PTSD | OR= 4.5, 95% CI= 0.83-24.41, P-value= 0.085 OR= 4.5, 95% CI= 0.83-24.41, P-value= 0.085 | A non-signficant trend for participants with the ll genotype...... A non-signficant trend for participants with the ll genotype to be more at risk of developing acute PTSD compared to those with the ss and sl genotypes was observed. More... | Non-significant |
| Walsh, K.,2014 | Arousal symptoms | 5-HTTLPR main effect, in DNHS: P-value>0.1; in GTP: P-valu...... 5-HTTLPR main effect, in DNHS: P-value>0.1; in GTP: P-value>0.1. More... | Among DNHS or GTP participants, 5-HTTLPR did not have a main...... Among DNHS or GTP participants, 5-HTTLPR did not have a main effect on any of the PTSD symptom clusters. More... | Non-significant |
| Walsh, K.,2014 | Avoidance symptoms | 5-HTTLPR main effect, in DNHS: P-value>0.1; in GTP: P-valu...... 5-HTTLPR main effect, in DNHS: P-value>0.1; in GTP: P-value>0.1. More... | Among DNHS or GTP participants, 5-HTTLPR did not have a main...... Among DNHS or GTP participants, 5-HTTLPR did not have a main effect on any of the PTSD symptom clusters. More... | Non-significant |
| Wang, Z.,2011 | CAPS score | R=0.15, P-value=0.03 R=0.15, P-value=0.03 | The correlation between the 5-HTTLPR and the CAPS score was ...... The correlation between the 5-HTTLPR and the CAPS score was significant. More... | Significant |
| Thakur, G. A., 2009 | Chronic PTSD | OR= 4.8, 95% CI= 1.09-21.22, P-value= 0.052 OR= 4.8, 95% CI= 1.09-21.22, P-value= 0.052 | At the 12-month assessment time, when patients with acute PT...... At the 12-month assessment time, when patients with acute PTSD who remitted were grouped with those who did not initially develop PTSD and compared to the chronic PTSD patients, the effect was stronger, whereby participants with the ss or sl genotypes were less likely to suffer from chronic PTSD as compared to the ll homozygotes. More... | Non-significant |
| Koenen, K. C.,2009 | Current diagnosis of PTSD | In every model, P>0.05. In every model, P>0.05. | There was no significant main effect for 5-HTTLPR genotype. There was no significant main effect for 5-HTTLPR genotype. | Non-significant |
| Liu, Y.,2015 | Current diagnosis of PTSD | Among NHB veterans, OR=1.502, P-value=.0025. Among NHW veter...... Among NHB veterans, OR=1.502, P-value=.0025. Among NHW veterans: P-value= .4671. More... | A significant additive effect was observed for 5-HTTLPR amon...... A significant additive effect was observed for 5-HTTLPR among NHB veterans, such that the odds of having a current diagnosis of PTSD increased by 1.502 for each additional S' allele. As can be seen in Fig. 1, the rate of PTSD was higher among S' homozygotes (87/160 or 54.38%) compared with heterozygotes (108/235 or 45.96%) and L' homozygotes (59/155 or 38.06%). No main effect was observed for 5-HTTLPR among NHW veterans. As can be seen in Fig. 1, the rate of PTSD among S' homozygotes (71/149 or 47.65%), heterozygotes (123/258 or 47.67%), and L' homozygotes (69/148 or 46.62%) was nearly identical. More... | Significant |
| Xie, P.,2009 | Lifetime PTSD | Logistic GEE regression analysis(after adjusting for age, se...... Logistic GEE regression analysis(after adjusting for age, sex, childhood adversity, and adult traumatic events): European American: OR=1.24; 95% CI=0.91-1.69; P-value=0.17; African American: OR=1.22; 95% CI=0.91-1.63; P-value=0.18. In the combined sample(ancestry proportion score was entered as a covariate): OR=1.22; 95% CI=0.99-1.51; P-value=0.07. More... | After adjusting for age, sex, childhood adversity, and adult...... After adjusting for age, sex, childhood adversity, and adult traumatic events, logistic GEE regression analysis showed no significant association between 5-HTTLPR genotype and PTSD diagnosis in either European American or African American individuals.The association in the combined sample, in which ancestry proportion score was entered as a covariate, was not statistically significant. The use of diallelic genotypes, which include only the L and S alleles of the 5-HTTLPR polymorphism, in the logistic regression analysis also showed that 5-HTTLPR genotypes were not associated with PTSD. In addition, none of the psychiatric disorders that were found to be comorbid with PTSD were associated with 5-HTTLPR genotypes. More... | Non-significant |
| Kolassa, I. T.,2010 | Lifetime PTSD | Main effect of genotype: LR=6.92, P-value=0.008. Main effect of genotype: LR=6.92, P-value=0.008. | The probability of developing lifetime PTSD was found to dep...... The probability of developing lifetime PTSD was found to depend on genotype. More... | Significant |
| Xie, P.,2012 | Lifetime PTSD | genotype (After adjusting for age and sex), EA: OR=0.97, 95...... genotype (After adjusting for age and sex), EA: OR=0.97, 95% CI=0.83-1.12, P-value=0.65; AA: OR=1.04, 95% CI=0.87-1.25, P-value=0.67. More... | After adjusting for age and sex, genotype was not significan...... After adjusting for age and sex, genotype was not significantly associated with PTSD. More... | Non-significant |
| Walsh, K.,2014 | Numbing symptoms | 5-HTTLPR main effect, in DNHS: P-value>0.1; in GTP: P-valu...... 5-HTTLPR main effect, in DNHS: P-value>0.1; in GTP: P-value>0.1. More... | Among DNHS or GTP participants, 5-HTTLPR did not have a main...... Among DNHS or GTP participants, 5-HTTLPR did not have a main effect on any of the PTSD symptom clusters. More... | Non-significant |
| Kimbrel, N. A.,2015 | PCL-M scores | Univariate effects for the 5-HTTLPR polymorphism on PTSD: i...... Univariate effects for the 5-HTTLPR polymorphism on PTSD: in total sample, P-value=0.002; in European Ancestry only, P-value<0.001. More... | Significant (P-value < .0083) univariate effects for the 5-H...... Significant (P-value < .0083) univariate effects for the 5-HTTLPR polymorphism were observed on the PCL-M (small effect). Notably, the effect of 5-HTTLPR polymorphism on post-deployment adjustment among individuals of European ancestry was larger than the effect observed in the overall sample. More... | Significant |
| Dunn, E. C.,2014 | Post Traumatic Growth (PTG) | T4: joint test P-value> 0.05, variant P-value> 0.05. T4: joint test P-value> 0.05, variant P-value> 0.05. | We did not find any significant associations between the gen...... We did not find any significant associations between the genetic variants and PTS (P-values > 0.05). More... | Non-significant |
| Kilpatrick, D. G.,2007 | Post-hurricane PTSD | Final Logistic Regression: Serotonin 5-HTTLPR genotype, Adj...... Final Logistic Regression: Serotonin 5-HTTLPR genotype, Adjusted Odds Ratio=0.3, 95%CI=0.1-1.1, P-value=0.07. More... | There was no significant result found between serotonin 5-HT...... There was no significant result found between serotonin 5-HTTLPR genotype with posthurricane PTSD in the Final Logistic Regression model. More... | Non-significant |
| Mercer, K. B.,2012 | Postshooting PTSD symptoms score (delta DEQ >1 month) | In all races or white participants only, P-value>0.05. In all races or white participants only, P-value>0.05. | We did not observe main effects for 5-HTTLPR alone on PTSD s...... We did not observe main effects for 5-HTTLPR alone on PTSD symptom score (2-4 week or >1 month delta DEQ). More... | Non-significant |
| Holman, E. A.,2011 | Posttraumatic stress (PTS) symptoms 2 years after 9/11 | (Participant age, gender, pre-9/11 mental and physical healt...... (Participant age, gender, pre-9/11 mental and physical health, 9/11-related exposure and acute stress, lifetime SLE, and amount of talking about future terrorism were included as controls) With controls: any short allele, b=-0.019, SE=0.019, P-value>0.05. More... | There isn't a significant association of any short allele wi...... There isn't a significant association of any short allele with PTSD symptoms 2 years after 9/11. More... | Non-significant |
| Holman, E. A.,2011 | Posttraumatic stress (PTS) symptoms 3 years after 9/11 | (Participant age, gender, pre-9/11 mental and physical healt...... (Participant age, gender, pre-9/11 mental and physical health, 9/11-related exposure and acute stress, lifetime SLE, and amount of talking about future terrorism were included as controls) With controls: any short allele, b=-0.0219, SE=0.022, P-value>0.05. More... | There isn't a significant association of any short allele wi...... There isn't a significant association of any short allele with PTSD symptoms 3 years after 9/11. More... | Non-significant |
| Dunn, E. C.,2014 | Post-traumatic stress symptoms (PTS) | T4: joint test P-value> 0.05, variant P-value> 0.05. T4: joint test P-value> 0.05, variant P-value> 0.05. | We did not find any significant associations between the gen...... We did not find any significant associations between the genetic variants and PTS (P-values > 0.05). More... | Non-significant |
| Mellman, T. A.,2009 | PTSD | Chi-square test: X2=1.0. Regression model: OR= ...... Chi-square test: X2=1.0. Regression model: OR= 1.3, 95% CI= 0.8-2.3 More... | PTSD was not significantly associated with 5HTTLPR functiona...... PTSD was not significantly associated with 5HTTLPR functional genotypes. The relationship of 5HTTLPR LE alleles to PTSD was not significant. More... | Non-significant |
| Navarro-Mateu, F.,2013 | PTSD | S allele vs L allele: OR=1.05; 95% CI=0.87, 1.26; P-value=0....... S allele vs L allele: OR=1.05; 95% CI=0.87, 1.26; P-value=0.63; I2=63; the dominant model,BDM (S+vs LL)OR=1.01;95% CI=0.78, 1.30; P-value=0.95; I2=57; the recessive model, BRM (SS vs L+) OR=1.15; 95%CI=0.82, 1.60; P-value=0.41; I2=55, respectively) (Figs 2, 3 and 4).Secondly, a meta-analysis of the triallelic approach offered similar results for the TFM model (OR=1.15; 95%CI=0.82,1.60; P-value=0.41; I2=74), for TDM model (OR=1.02; 95%CI=0.73, 1.48; P-value=0.93; I2= 43) and for the TRM (OR=1.31; 95%CI=71, 2.41; P-value=0.38; I2=80) (Figs 5, 6 and 7, respectively).0.66, 1.74; I2=78% and TFM, OR=1.14; 95% CI: 0.70, 1.87; I2=81%), in the dominant model (BDM, OR=1.09; 95% CI: 0.61, 1.96; I2=72%, TDM, OR=0.93; 95% CI: 0.60, 1.44; I2=39%) and in the recessive model (BRM, OR=1.05; 95% CI: 0.41, 2.67; I2=73%, TRM, OR=1.40; 95% CI: 0.54, 3.57;I2=85%). More... | This is the first published meta-analysis of the relationshi...... This is the first published meta-analysis of the relationship between 5-HTTLPR polymorphisms and PTSD. They found no significant relationship between biallelic or triallelic polymorphism and PTSD, using the three possible approaches (allele frequency, dominant and recessive model). More... | Non-significant |
| Gressier, F.,2013 | PTSD | Association between PTSD and SS genotype: z=1.64, P-value=....... Association between PTSD and SS genotype: z=1.64, P-value=.10, heterogeneity: X2=40.59, P-value<.001, I2=73. An analysis grouping SS and SL versus LL participants and considering allele frequencies (S vs. L), odds ratio (OR)=0.88, 95%CI=0.67-1.15, z=0.94, P-value=.35; and OR=1.08, 95%CI=0.88-1.32, z=0.72, P-value=.47; heterogeneity: X2= 21.39, P-value=.03, I2= 49, and X2= 28.94, P-value=.002, I2= 62, respectively. More... | Random effects indicated no association between PTSD and SS ...... Random effects indicated no association between PTSD and SS genotype. However, there was evidence of high between-study heterogeneity. Egger's test indicated no evidence of publication bias. We explored gender and age as covariates with meta-regression, and found a gender-dependent association, but no influence of age. Consequently, gender explained part of the heterogeneity between studies. We also performed an analysis grouping SS and SL versus LL participants and considering allele frequencies (S vs. L). In both cases no association was found and a high between-study heterogeneity was identified. More... | Non-significant |
| Tian, Y.,2015 | PTSD | Allele frequence (L+ vs L vs S): P-value<0.001. Genotype fr...... Allele frequence (L+ vs L vs S): P-value<0.001. Genotype frequence (LL vs LS vs L+S vs SS vs L+L): P-value<0.001. More... | There were significant differences between adolescents with ...... There were significant differences between adolescents with and without PTSD for 5-HTTLPR genotype, and the allele frequencies also differed significantly between the two groups. More... | Significant |
| Telch, M. J.,2015 | PTSD | B=-0.18, P-value>0.55 B=-0.18, P-value>0.55 | There was no significant main effect of 5-HTTLPR genotype on...... There was no significant main effect of 5-HTTLPR genotype on any of the three indices of war zone stress reactions. More... | Non-significant |
| Valente, N. L.,2011 | PTSD | Chi-square test. PTSD+, PTSD?, and community control groups...... Chi-square test. PTSD+, PTSD?, and community control groups: genotype: P-value= 0.27 More... | We did not find statistically significant difference son gen...... We did not find statistically significant difference son genotypic and allelic frequencies of the short/long variants of serotonin transporter gene on PTSD+ and PTSD? groups and community control group. More... | Non-significant |
| Grabe, H. J.,2009 | PTSD category B symptom score | Genotypes: P-value>=0.05 Genotypes: P-value>=0.05 | No associations were established between the 5-HTTLPR genoty...... No associations were established between the 5-HTTLPR genotypes and criteria B, C,or D. More... | Non-significant |
| Grabe, H. J.,2009 | PTSD category C symptom score | Genotypes: P-value>=0.05 Genotypes: P-value>=0.05 | No associations were established between the 5-HTTLPR genoty...... No associations were established between the 5-HTTLPR genotypes and criteria B, C,or D. More... | Non-significant |
| Grabe, H. J.,2009 | PTSD category D symptom score | Genotypes: P-value>=0.05 Genotypes: P-value>=0.05 | No associations were established between the 5-HTTLPR genoty...... No associations were established between the 5-HTTLPR genotypes and criteria B, C,or D. More... | Non-significant |
| Grabe, H. J.,2009 | PTSD diagnosis | Genotypes: unadjusted: P-value=0.04, age and gender adjust...... Genotypes: unadjusted: P-value=0.04, age and gender adjusted: P-value=0.05. Number of LA alleles: unadjusted: P-value=0.01, age and gender adjusted: P-value=0.01. More... | All associations between the LA/LA genotype and PTSD (both c...... All associations between the LA/LA genotype and PTSD (both crude and adjusted) were statistically significant. More... | Significant |
| Pietrzak, R. H.,2013 | PTSD diagnosis | S' allele: Wald=2.47, OR=7.46, 95%CI=0.61-91.46 S' allele: Wald=2.47, OR=7.46, 95%CI=0.61-91.46 | Main effects of 5-HTTLPR genotype was not significant in the...... Main effects of 5-HTTLPR genotype was not significant in these analyses. More... | Non-significant |
| Wang, Z.,2011 | PTSD severity | OR=1.77, 95%CI: 1.33-2.35, P-value=0.000102 OR=1.77, 95%CI: 1.33-2.35, P-value=0.000102 | The S' allele predicted the PTSD severity score. The S' allele predicted the PTSD severity score. | Significant |
| Walsh, K.,2014 | PTSD severity | 5-HTTLPR main effect, in DNHS: P-value>0.1; in GTP: P-valu...... 5-HTTLPR main effect, in DNHS: P-value>0.1; in GTP: P-value<0.05. More... | Among DNHS participants, 5-HTTLPR did not have a main effect...... Among DNHS participants, 5-HTTLPR did not have a main effect on PTSD symptom total. Among GTP participants, 5-HTTLPR genotype exerted a significant main effect on total PTSD symptom severity such that those with the low expression/SS alleles had lower total PTSD symptom severity relative to those with the higher expression/SL or LL alleles. More... | Significant |
| Wang, Z.,2011 | PTSD status | Whole sample: Chi-square linear-by-linear association test:...... Whole sample: Chi-square linear-by-linear association test: X2=16.23, P-value=5.62E-05. After controlling for demographic variables: OR=1.77. Caucasian subsample: OR= 1.92 More... | There is a significant association between the 5HTTLPR polym...... There is a significant association between the 5HTTLPR polymorphism and PTSD status, reflecting the higher prevalence of the S'/S' genotype in cases (45%) versus controls (17%). The S' allele of the 5HTTLPR remained significantly associated with increased likelihood of having PTSD after controlling for demographic variables. When selecting the subset of participants who were Caucasian ( n =271), results were similar to those of the full sample, with the S' allele being associated with PTSD. More... | Significant |
| La Greca, A. M.,2013 | PTSD symptoms | Main effect of genotype on PTSD symptoms, P-value>0.05. Main effect of genotype on PTSD symptoms, P-value>0.05. | There was no main effect of genotype on PTSD symptoms. There was no main effect of genotype on PTSD symptoms. | Non-significant |
| Goenjian, A. K.,2012 | PTSD-RI (PTSD symptoms) | After adjusting for age, sex, exposure and environmental var...... After adjusting for age, sex, exposure and environmental variables, analyses of PTSD-RI and this variant: P-value>0.05. More... | There was no significant association of either 's' or 'l' al...... There was no significant association of either 's' or 'l' allele and PTSD-RI scores. More... | Non-significant |
| Olsson, A.,2015 | PTSS scores | t(16) = 3.45, P-value=0.003, d=1.73 t(16) = 3.45, P-value=0.003, d=1.73 | PTSS scores were significantly related to the 5-HTT genotype...... PTSS scores were significantly related to the 5-HTT genotype. The 9/11 survivors carrying the low expressive short allele (n=11) were characterized by significantly higher levels of PTSS than 9/11 survivors with the long homozygote version of the allele (n=6). More... | Significant |
| Kimbrel, N. A.,2015 | QOLS scores | Univariate effects for the 5-HTTLPR polymorphism on QOLS sco...... Univariate effects for the 5-HTTLPR polymorphism on QOLS scores: in total sample, P-value=0.001; in European Ancestry only, P-value<0.001. More... | Significant (P-value < .0083) univariate effects for the 5-H...... Significant (P-value < .0083) univariate effects for the 5-HTTLPR polymorphism were observed on QOLS (medium effect). Notably, the effect of 5-HTTLPR polymorphism on post-deployment adjustment among individuals of European ancestry was larger than the effect observed in the overall sample. More... | Significant |
| Walsh, K.,2014 | Reexperiencing symptoms | 5-HTTLPR main effect, in DNHS: P-value>0.1; in GTP: P-valu...... 5-HTTLPR main effect, in DNHS: P-value>0.1; in GTP: P-value>0.1. More... | Among DNHS or GTP participants, 5-HTTLPR did not have a main...... Among DNHS or GTP participants, 5-HTTLPR did not have a main effect on any of the PTSD symptom clusters. More... | Non-significant |
| Pietrzak, R. H.,2013 | Severity of PTSD symptoms | S' allele: B=0.15, P-value=0.08 (adjustment for age, sex, an...... S' allele: B=0.15, P-value=0.08 (adjustment for age, sex, and ancestral proportion scores). More... | Main effects of 5-HTTLPR genotype was not significant in the...... Main effects of 5-HTTLPR genotype was not significant in these analyses. More... | Non-significant |
Gene*Environment study related association results (count: 33)
| Reference | Phenotype | Environment | Statistical Values | Author Comments | Marker's Category |
|---|---|---|---|---|---|
| Pietrzak, R. H.,2013 | Anxious arousal symptoms | High exposure | The interaction of 5-HTTPLR S' allele x exposure:B=.44, t=5....... The interaction of 5-HTTPLR S' allele x exposure:B=.44, t=5.47, P-value<.001 More... | Secondary analyses revealed that the 5-HTTLPR S' allele x ex...... Secondary analyses revealed that the 5-HTTLPR S' allele x exposure interaction was significantly associated with anxious arousal symptoms. More... | Significant |
| Walsh, K.,2014 | Arousal symptoms | Emotional Abuse | 5-HTTLPR and Emotional Abuse interaction, in DNHS: F-value=5...... 5-HTTLPR and Emotional Abuse interaction, in DNHS: F-value=5.80, P-value<0.01; in GTP: F-value=3.18, P-value<0.05. Any S allele interacted with emotional abuse: in DNHS, F(1,129) = 4.80, P-value= .03, and GTP, F(1,538) = 5.70, P-value= .017. More... | A significant interaction was observed between 5-HTTLPR geno...... A significant interaction was observed between 5-HTTLPR genotype and emotional abuse on worst arousal symptom severity after controlling for age and sex among DNHS participants. A significant interaction between 5-HTTLPR genotype and emotional abuse emerged for the arousal symptom clusters among GTP participants. More... | Significant |
| Walsh, K.,2014 | Avoidance symptoms | Emotional Abuse | 5-HTTLPR and Emotional Abuse interaction, in DNHS: F-value=0...... 5-HTTLPR and Emotional Abuse interaction, in DNHS: F-value=0.46, P-value.0.1; in GTP: F-value=0.30, P-value>0.1. More... | The interaction between 5-HTTLPR and emotional abuse did not...... The interaction between 5-HTTLPR and emotional abuse did not reach statistical significance for the avoidance symptom severity among DNHS or GTP participants. More... | Non-significant |
| Pietrzak, R. H.,2013 | Avoidance symptoms | High exposure | The interaction of 5-HTTPLR S' allele x exposure:B=.08, t=.5...... The interaction of 5-HTTPLR S' allele x exposure:B=.08, t=.55, P-value<=.59 More... | Secondary analyses revealed that the 5-HTTLPR S' allele x ex...... Secondary analyses revealed that the 5-HTTLPR S' allele x exposure interaction was not significantly associated with avoidance symptoms. More... | Non-significant |
| Koenen, K. C.,2009 | Current Diagnosis of PTSD | Crime rate | Multivariable logistic regression models for crime rate and ...... Multivariable logistic regression models for crime rate and PTSD: in the interaction model, 5-HTTLPR genotype x crime rate: P-value=0.03. Stratified analyses: s' allele of 5-HTTLPR living in low-crime counties), odds ratio (OR)=0.61, 95%CI=0.34, 1.10; in high-crime counties: OR=1.54, 95%CI=0.72, 3.30. More... | Multivariable logistic regression models for crime rate and ...... Multivariable logistic regression models for crime rate and PTSD: In the interaction model, the interaction term for 5-HTTLPR genotype x crime rate was significant. Figure 1 presents the prevalence of PTSD for persons from high-crime-rate counties versus persons from low-crime-rate counties by 5-HTTLPR genotype. Stratified analyses showed that the s' allele of 5-HTTLPR predicted decreased risk of PTSD among persons living in low-crime counties but increased risk in high-crime counties. More... | Significant |
| Koenen, K. C.,2009 | Current Diagnosis of PTSD | Unemployment rate | Multivariable logistic regression models for unemployment ra...... Multivariable logistic regression models for unemployment rate and PTSD: in the interaction model, 5-HTTLPR genotype x unemployment rate: P-value=0.007. Stratified analyses: s' allele of 5-HTTLPR living in low-unemployment counties:OR=0.35, 95%CI=0.14-0.87; in high-unemployment counties: OR=1.46, 95%CI=0.82-2.61. More... | Multivariable logistic regression models for unemployment ra...... Multivariable logistic regression models for unemployment rate and PTSD: in the interaction model, the interaction term for 5-HTTLPR genotype x unemployment rate was significant. Figure 2 presents the prevalence of PTSD for persons from counties with high unemployment versus those with low unemployment by 5-HTTLPR genotype. Stratified analyses showed that the s' allele of 5-HTTLPR predicted decreased risk of PTSD among persons living in low-unemployment counties but increased risk in high-unemployment counties. Note that because of the loss of power in stratified analyses, only the effect of 5-HTTLPR genotype in low-unemployment counties was statistically significant. More... | Significant |
| Pietrzak, R. H.,2013 | Diagnosis of PTSD | High exposure | The interaction of 5-HTTPLR genotype x exposure: Wald=4.55, ...... The interaction of 5-HTTPLR genotype x exposure: Wald=4.55, OR=3.81, 95%CI=1.11-13.03, P-value<0.05. More... | Results of these analyses revealed that after adjustment for...... Results of these analyses revealed that after adjustment for age, sex, and ancestral proportion scores, the interaction of 5-HTTPLR genotype x exposure was significantly associated with probable diagnosis of Ike-related PTSD. More... | Significant |
| Pietrzak, R. H.,2013 | Dysphoric arousal symptoms | High exposure | The interaction of 5-HTTPLR S' allele x exposure:B=.13, t=.9...... The interaction of 5-HTTPLR S' allele x exposure:B=.13, t=.93, P-value<=.36 More... | Secondary analyses revealed that the 5-HTTLPR S' allele x ex...... Secondary analyses revealed that the 5-HTTLPR S' allele x exposure interaction was not significantly associated with dysphoric arousal symptoms. More... | Non-significant |
| Xie, P.,2012 | Lifetime PTSD | Childhood adversity (participants were asked whether, by age 13, they had witnessed or experienced a violent crime, had been sexually abused, or had been physically abused) | 5-HTTLPR genotype x childhood adversity interaction: EA, OR=...... 5-HTTLPR genotype x childhood adversity interaction: EA, OR=1.49, 95% CI=1.07-2.08, P-value=0.019; AA, OR=0.90, 95% CI=0.60-1.35, P-value=0.62. In combined sample:EA, OR=1.52, 95% CI=1.12-2.06, P-value=0.0069; AA, OR=1.14, 95% CI=0.79-1.64, P-value=0.50. More... | 5-HTTLPR genotype x childhood adversity interaction was sign...... 5-HTTLPR genotype x childhood adversity interaction was significantly associated with lifetime PTSD diagnosis in EAs, but not in AAs. The interaction effect was calculated again after adding the diagnosis of major depressive disorder into the logistic regression model as a covariate. Including depression in the model did not change the interaction effect on PTSD. We combined the data from the current study with those from our previous study investigating the interaction effect of 5-HTTLPR and childhood adversity on PTSD risk. With the increased sample size, the power to detect the interaction effect is increased, but the effect in AAs remained non-significant. After adjusting for the effects of substance dependence, the interaction of childhood adversity and 5-HTTLPR genotype on PTSD diagnosis remained largely unchanged. More... | Significant |
| Xie, P.,2009 | Lifetime PTSD | Childhood adversity, adult traumatic events | 2-way interactions, genotype x adult traumatic events intera...... 2-way interactions, genotype x adult traumatic events interaction, European American: OR=2.60; 95% CI=1.19-5.66; P-value=0.02; African American: OR=2.06; 95% CI=1.02-4.14; P-value=0.04; the combination of the 2 populations:OR=1.93; 95% CI=1.17-3.17; P-value=0.01. genotype x childhood adversity interaction: European American: OR=3.29; 95% CI=1.17-9.22; P-value=0.02; African American: OR=1.71; 95% CI=0.81-3.61; P-value=0.16, the combination of the 2 populations: OR=1.81; 95% CI=1.01-3.24; P-value=0.046. The genotype x dual stressful events interaction:European American: OR=2.86; 95% CI=1.50-5.45; P-value=.002; African American: OR=1.88; 95% CI=1.04-3.40; P-value=0.04, the combination of the 2 populations:OR=2.31; 95% CI=1.50-3.56; P-value<.001. More... | 5-HTTLPR genotypes interacted with childhood adversity and a...... 5-HTTLPR genotypes interacted with childhood adversity and adult traumatic events to increase risk for developing PTSD. More... | Significant |
| Kolassa, I. T.,2010 | Lifetime PTSD | NTE (number of traumatic events) | LR=7.85, P-value=0.11. LR=7.85, P-value=0.11. | There was a trend toward an interaction between genotype gro...... There was a trend toward an interaction between genotype groups and number of traumatic events experienced. More... | Non-significant |
| Walsh, K.,2014 | Numbing symptoms | Emotional Abuse | 5-HTTLPR and Emotional Abuse interaction, in DNHS: F-value=0...... 5-HTTLPR and Emotional Abuse interaction, in DNHS: F-value=0.44, P-value>0.1; in GTP: F-value=3.57, P-value<0.05. More... | The interaction between 5-HTTLPR and emotional abuse did not...... The interaction between 5-HTTLPR and emotional abuse did not reach statistical significance for the numbing symptom severity among DNHS participants. A significant interaction between 5-HTTLPR genotype and emotional abuse emerged for the numbing symptom clusters among GTP participants. More... | Significant |
| Pietrzak, R. H.,2013 | Numbing symptoms | High exposure | The interaction of 5-HTTPLR S' allele x exposure:B=.20, t=1....... The interaction of 5-HTTPLR S' allele x exposure:B=.20, t=1.49, P-value<=.14 More... | Secondary analyses revealed that the 5-HTTLPR S' allele x ex...... Secondary analyses revealed that the 5-HTTLPR S' allele x exposure interaction was not significantly associated with numbing symptoms. More... | Non-significant |
| Dunn, E. C.,2014 | Post Traumatic Growth (PTG) | Hurricane exposure | T4: joint test P-value> 0.05, GxE interaction P-value= 0.025...... T4: joint test P-value> 0.05, GxE interaction P-value= 0.025. More... | We found a significant association between 5-HTTLPR x exposu...... We found a significant association between 5-HTTLPR x exposure interaction and PTG. More... | Significant |
| Kilpatrick, D. G.,2007 | Post-hurricane PTSD | High hurricane exposure, Low social support | 5-HTTLPR genotype and high hurricane exposure:X2=...... 5-HTTLPR genotype and high hurricane exposure:X2=0.28, df=2, P-value=0.78; 5-HTTLPR genotype and low social support: X2=2.00, df=2, P-value=0.37. The three-way-interaction term for 5-HTTLPR genotype, social support, and hurricane exposure in the adjusted logistic regression model for posthurricane PTSD diagnosis: Wald X2=4.76, df=1, P-value<0.03; odds ratio=4.5, 95% confidence interval [CI]=1.2-17.4. For post hoc analyses, high-risk (N=27, were those with the short/short genotype, low social support, and high hurricane exposure) group vs. low-risk (N=498, were all others) group: odds ratio=20.1, 95% CI=1.4-296.6, P-value=0.03; high-risk group vs. medium risk (N=54, were those with the long/short genotype, low social support, and high hurricane exposure) group: odds ratio=5.0, 95% CI=0.8-30.8, P-value=0.09; medium-risk group vs. low-risk group:odds ratio=4.1, 95% CI=0.6-26.3, P-value=0.14. Secondary analyses were conducted with European Americans only (N=530), three-way interaction term for 5-HTTLPR genotype, social support, and hurricane exposure: odds ratio=4.1, 95% CI=0.9-9.5, P-value=0.07. More... | The two-way interaction terms for genotype by hurricane expo...... The two-way interaction terms for genotype by hurricane exposure and for genotype by social support were not significant for PTSD. The three-way-interaction term for 5-HTTLPR genotype, social support, and hurricane exposure was significant in the adjusted logistic regression model for posthurricane PTSD diagnosis. For post hoc analyses, adults in the high-risk group were significantly more likely to have posthurricane PTSD than those in the low-risk group. The high-risk group showed a tendency toward being more likely to develop PTSD than the medium-risk group. The medium-risk group was not significantly more likely to have PTSD than the low-risk group. Secondary analyses were conducted with European Americans only (N=530). The results paralleled those for the entire cohort. The three-way interaction term for 5-HTTLPR genotype, social support, and hurricane exposure showed a strong tendency for PTSD diagnosis. More... | Significant |
| Mercer, K. B.,2012 | Postshooting PTSD symptoms score (delta DEQ >1 month) | Shooting exposure | White participants only: P-value>0.01. White participants only: P-value>0.01. | Not significant. Not significant. | Non-significant |
| Holman, E. A.,2011 | Posttraumatic stress (PTS) symptoms 2 years after 9/11 | Social constraints | any short allele x social constraints, with controls:b=0.039...... any short allele x social constraints, with controls:b=0.039, SE=0.013, P-value<=0.01 More... | Genotype interacted with social constraints to predict highe...... Genotype interacted with social constraints to predict higher PTS symptoms. Examination of simple slopes revealed a significant positive association between social constraints and PTS symptoms for individuals with an s/lg allele but not for those individuals without an s/lg allele (see Figure 1a). Under low social constraints, genotype was unrelated to PTS symptoms; under high social constraints, respondents with an s/lg allele reported significantly higher PTS symptoms than those with the la/la genotype. More... | Significant |
| Holman, E. A.,2011 | Posttraumatic stress (PTS) symptoms 3 years after 9/11 | Social constraints | any short allele x social constraints, with controls:b=0.032...... any short allele x social constraints, with controls:b=0.032, SE=0.015, P-value<0.05 More... | There was a significant positive association between social ...... There was a significant positive association between social constraints and PTS symptoms for individuals with and without short alleles (Table 3; Figure 1b). Although both simple slopes were significantly different from zero, the significant interaction term indicated that the association between social constraints and PTS symptoms for individuals with an s/lg allele was significantly stronger than the relationship between social constraints and PTS symptoms for la/la individuals. Under low social constraints, genotype was unrelated to PTS symptoms; under high social constraints, respondents with an s/lg allele reported significantly higher PTS symptoms than those with the la/la genotype. More... | Significant |
| Dunn, E. C.,2014 | Post-traumatic stress symptoms (PTS) | Hurricane exposure | Genetic variants and T3 or T4 PTS interaction: all P-values ...... Genetic variants and T3 or T4 PTS interaction: all P-values > 0.05. More... | We did not find any significant associations between the gen...... We did not find any significant associations between the genetic variants and T3 or T4 PTS (all P-values > 0.05). More... | Non-significant |
| Telch, M. J.,2015 | PTSD | Average level of war zone stressors | MRM analyses: genotype: b=0.21, t=2.08, P-value<0.05. Separa...... MRM analyses: genotype: b=0.21, t=2.08, P-value<0.05. Separately for S' carriers: b=0.28, t=4.01, P-value<0.0001. Separately for L' homozygote: b=0.07, t=0.86, P-value>0.39. More... | MRM analyses revealed significant interactions between 5-HTT...... MRM analyses revealed significant interactions between 5-HTTLPR genotype and average level of war zone stressors during deployment for all three measures of war zone stress reactions. For L' homozygotes, higher levels of average stress reported in the ?eld did not predict higher symptoms, In contrast, and consistent with our hypothesis, S' carriers responded to higher levels of average stress with higher levels of PTSD symptoms. More... | Significant |
| Telch, M. J.,2015 | PTSD | Average level of war zone stressors, Race | Three way interaction: p-values ranged between 0.17 and 0.4...... Three way interaction: p-values ranged between 0.17 and 0.47 More... | The race x war zone stressors x 5-HTTLPR genotype interactio...... The race x war zone stressors x 5-HTTLPR genotype interaction for PTSD was not significant, indicating that the observed war zone stressors x 5-HTTLPR genotype interactions were not influenced by soldiers'race. More... | Non-significant |
| Telch, M. J.,2015 | PTSD | Change in stress | MRM analyses: genotype: b=-0.14, P-value>0.05 MRM analyses: genotype: b=-0.14, P-value>0.05 | Not significant effect. Not significant effect. | Non-significant |
| Tian, Y.,2015 | PTSD | Earthquake exposure | Interaction effect of genotype and earthquake exposure: OR=4...... Interaction effect of genotype and earthquake exposure: OR=4.304, 95%CI=1.285-14.414, P-value=0.018. More... | The interaction effects of this genotype with earthquake exp...... The interaction effects of this genotype with earthquake exposure was statistically significant. More... | Significant |
| Grabe, H. J.,2009 | PTSD category B symptom score | NTE (number of traumatic events) | No detail information No detail information | No statistically significant interactions emerged when perfo...... No statistically significant interactions emerged when performing the analyses for B and C criteria irrespective of the trauma threshold. More... | Non-significant |
| Grabe, H. J.,2009 | PTSD category C symptom score | NTE (number of traumatic events) | No detail information No detail information | No statistically significant interactions emerged when perfo...... No statistically significant interactions emerged when performing the analyses for B and C criteria irrespective of the trauma threshold. More... | Non-significant |
| Grabe, H. J.,2009 | PTSD category D symptom score | NTE (number of traumatic events) | RERI for the continuous genetic model (zero, one, or two LA ...... RERI for the continuous genetic model (zero, one, or two LA alleles) was 1.2 (95% CI=0.5-2.8, P-value<0.05). More... | Statistically significant interactions was found between num...... Statistically significant interactions was found between number of traumatic events and 5-HTTLPR genotype. More... | Significant |
| Grabe, H. J.,2009 | PTSD diagnosis | NTE (number of traumatic events) | Three as a cutoff point for the number of traumas: RERI was ...... Three as a cutoff point for the number of traumas: RERI was 1.3 for the unadjusted model and 1.5 (95% CI=0.5-4.3, P-value<0.05) for the fully adjusted model. Four as a cutoff point for the number of traumas: RERI increased to 1.8 (95% CI=1.6-31.7, P-value<0.05). When two was used as a cutoff point for the number of traumas, no statistically significant interactions emerged. For the final model, RERI was 3.3. More... | Statistically significant interactions was found between num...... Statistically significant interactions was found between number of traumatic events and 5-HTTLPR genotype. More... | Significant |
| Walsh, K.,2014 | PTSD severity | Emotional Abuse | 5-HTTLPR and Emotional Abuse interaction, in DNHS: F-value=2...... 5-HTTLPR and Emotional Abuse interaction, in DNHS: F-value=2.67, P-value<0.1; in GTP: F-value=2.97, P-value<0.1. More... | The interaction between 5-HTTLPR and emotional abuse did not...... The interaction between 5-HTTLPR and emotional abuse did not reach statistical significance for total PTSD symptom severity among DNHS or GTP participants. More... | Non-significant |
| Liu, Y.,2015 | PTSD status | Combat exposure | Logistic regression model 5-HTTLPR x combat exposure interac...... Logistic regression model 5-HTTLPR x combat exposure interaction term, on the NHB sample: P-value=.65; on the NHW sample: P-value=.51. More... | A second logistic regression model was conducted on the NHB ...... A second logistic regression model was conducted on the NHB sample to test for potential 5-HTTLPR x combat exposure effects on PTSD status. The results from this model were highly similar to the first. 5-HTTLPR, civilian trauma, combat trauma, and PC1 all continued to have significant main effects on PTSD; however, no other variable in the model, including the 5-HTTLPR x combat exposure interaction term, was significant. Similar results were obtained from the second logistic regression model that tested for 5-HTTLPR x combat exposure effects on PTSD among NBW sample. More... | Non-significant |
| La Greca, A. M.,2013 | PTSD symptoms | Environmental stressors | P-value>.10 P-value>.10 | There was little support for a GxE interaction in predicting...... There was little support for a GxE interaction in predicting children's symptoms of PTSD or depression. For the outcome of PTSD symptoms, no interactions approached significance (based on p<.10). More... | Non-significant |
| Walsh, K.,2014 | Reexperiencing symptoms | Emotional Abuse | 5-HTTLPR and Emotional Abuse interaction, in DNHS: F-value=4...... 5-HTTLPR and Emotional Abuse interaction, in DNHS: F-value=4.08, P-value<0.05; in GTP: F-value=3.56, P-value<0.05. In GTP, any S allele also interacted with emotional abuse to predict re-experiencing symptoms, F(1,538) = 3.76, P-value= .053. More... | A significant interaction was observed between 5-HTTLPR geno...... A significant interaction was observed between 5-HTTLPR genotype and emotional abuse on worst reexperiencing symptom severity after controlling for age and sex among DNHS participants. A significant interaction between 5-HTTLPR genotype and emotional abuse emerged for the reexperiencing symptom clusters among GTP participants. More... | Significant |
| Pietrzak, R. H.,2013 | Reexperiencing symptoms | High exposure | The interaction of 5-HTTPLR S' allele x exposure:B=.35, t=4....... The interaction of 5-HTTPLR S' allele x exposure:B=.35, t=4.56, P-value<<.001 More... | Secondary analyses revealed that the 5-HTTLPR S' allele x ex...... Secondary analyses revealed that the 5-HTTLPR S' allele x exposure interaction was significantly associated with re-experiencing symptoms. More... | Significant |
| Pietrzak, R. H.,2013 | Severity of PTSD symptoms | High exposure | The interaction of 5-HTTPLR genotype x exposure: B=0.40, P-v...... The interaction of 5-HTTPLR genotype x exposure: B=0.40, P-value<0.001. More... | Results of these analyses revealed that after adjustment for...... Results of these analyses revealed that after adjustment for age, sex, and ancestral proportion scores, the interaction of 5-HTTPLR genotype x exposure was significantly associated with severity of Ike-related PTSD. More... | Significant |
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