Study Report
Study Information
Basic Info
| Reference |
Zhao, L. S.,2012 PMID: 22997896
|
| Citation |
Zhao, L. S., et al. (2012). "Association study of the 5-HTT polymorphism and posttraumatic stress disorder in adolescents." Sichuan Da Xue Xue Bao Yi Xue Ban 43(4): 558-561. |
| Phenotype |
PTSD |
| Trauma |
2008 Wenchuan earthquake |
| Study Design |
Case-control |
| Study Type |
Candidate gene association study |
| Sample Size |
236 cases, 234 controls |
| SNP/Marker Size |
1 Variant |
| Predominant Ethnicity |
Mongloid |
| Population |
Chinese |
| Gender |
Case: 97 males and 139 females, Control: 99 males and 135 females |
| Age |
Case: mean age=13.7 years,SD=1, Control: mean age=15.1 years,SD=2 |
Detail Info
| Sample Diagnosis |
DSM-IV |
| Related Diagnostic Tools |
Children's reviesd impact of event scale(CRIES), Self-edited questionaire including the detail informaton and earthquake experience of subjects. |
| Sample Status |
None |
| Controls Exposed |
Yes |
| Replication Size |
None |
| Result Summary |
The allele 12 of 5-HTTVNTR may increase the risk of PTSD in Chinese Han adolescents, 12/12 genotype may be the susceptibility gene, and heterozygote 10/12 may act as the protective factor of PTSD. |
| Potential Biomarker |
None |
Genetic result reported by this study
Normal genetic result reported by this study (count: 1)
| Marker |
Phenotype |
Related Gene |
Statistical Values |
Author Comments |
Marker's Category |
|
5-HTT_intron 2_VNTR
|
PTSD |
SLC6A4 |
Allele: X2=5.42, P-value=0.020, genotype: P-value=0.023 |
The frequency of 5-HTTVNTR allele 12 in PTSD group was signi......
The frequency of 5-HTTVNTR allele 12 in PTSD group was significantly higher than control group.
More...
|
Significant |
