PTSDgene database

Study Report

Study Information
Basic Info
Reference
Citation Goenjian, A. K., et al. (2012). "Association of TPH1, TPH2, and 5HTTLPR with PTSD and depressive symptoms." J Affect Disord 140(3): 244-252.
Phenotype PTSD-RI (PTSD symptoms)
Trauma 1988 Spitak earthquake
Study Design Pedigree-based
Study Type Candidate gene association study
Sample Size 200 adults
SNP/Marker Size 8 SNPs, 1 Variant
Predominant Ethnicity Caucasian
Population Armenian
Gender 79 males, 121 females
Age No detial information (adults).

Detail Info

Genetic result reported by this study
Normal genetic result reported by this study (count: 9)
Marker Phenotype Related Gene Statistical Values Author Comments Marker's Category
rs2129575 PTSD-RI (PTSD symptoms) TPH2 After adjusting for age, sex, exposure and environmental variables, analyses of PTSD-RI and this SNP: P-value>0.05. The remainder of the TPH2 SNPs tested did not show a signifi...... The remainder of the TPH2 SNPs tested did not show a significant association with PTSD-RI scores; and the linkage scores were below 1.0. More... Non-significant
rs4290270 PTSD-RI (PTSD symptoms) TPH2 After adjusting for age, sex, exposure and environmental variables, analyses of PTSD-RI and this SNP: P-value>0.05. The remainder of the TPH2 SNPs tested did not show a signifi...... The remainder of the TPH2 SNPs tested did not show a significant association with PTSD-RI scores; and the linkage scores were below 1.0. More... Non-significant
rs1799913 PTSD-RI (PTSD symptoms) TPH1 After adjusting for age, sex, exposure and environmental variables, the family based variance component analyses of PTSD-RI with rs1799913: P-value=0.69, lod score=0.56. No significant association was observed. No significant association was observed. Non-significant
rs2108977 PTSD-RI (PTSD symptoms) TPH1 After adjusting for age, sex, exposure and environmental variables, the family based variance component analyses of PTSD-RI with the 't' allele of SNP rs2108977: X2=8.44, df=1, P-value < 0.004. Lod score=1.05. After adjusting for age, sex, exposure and environmental var...... After adjusting for age, sex, exposure and environmental variables, the family based variance component analyses revealed a significant association of PTSD-RI with the 't' allele of TPH1 SNP rs2108977. This gene explained 3% of the variance in PTSD-RI scores. More... Significant
rs1386494 PTSD-RI (PTSD symptoms) TPH2 After adjusting for age, sex, exposure and environmental variables, analyses of PTSD-RI and this SNP: P-value>0.05. The remainder of the TPH2 SNPs tested did not show a signifi...... The remainder of the TPH2 SNPs tested did not show a significant association with PTSD-RI scores; and the linkage scores were below 1.0. More... Non-significant
rs17110747 PTSD-RI (PTSD symptoms) TPH2 After adjusting for age, sex, exposure and environmental variables, analyses of PTSD-RI and this SNP: P-value>0.05. The remainder of the TPH2 SNPs tested did not show a signifi...... The remainder of the TPH2 SNPs tested did not show a significant association with PTSD-RI scores; and the linkage scores were below 1.0. More... Non-significant
rs11178997 PTSD-RI (PTSD symptoms) TPH2 After adjusting for age, sex, exposure and environmental variables, analyses of PTSD-RI and the 't' allele of TPH2 SNP rs11178997: X2=3.87, df=1, P-value=0.03. Lod score=0.02. After adjusting for age, sex, exposure and environmental var...... After adjusting for age, sex, exposure and environmental variables, analyses indicated a significant association of PTSD-RI and the 't' allele of TPH2 SNP rs11178997. This gene explained 4% of the variance of PTSD-RI scores. More... Significant
5-HTTLPR PTSD-RI (PTSD symptoms) SLC6A4 After adjusting for age, sex, exposure and environmental variables, analyses of PTSD-RI and this variant: P-value>0.05. There was no significant association of either 's' or 'l' al...... There was no significant association of either 's' or 'l' allele and PTSD-RI scores. More... Non-significant
rs4570625 PTSD-RI (PTSD symptoms) TPH2 After adjusting for age, sex, exposure and environmental variables, analyses of PTSD-RI and this SNP: P-value>0.05. The remainder of the TPH2 SNPs tested did not show a signifi...... The remainder of the TPH2 SNPs tested did not show a significant association with PTSD-RI scores; and the linkage scores were below 1.0. More... Non-significant