PTSDgene database

Pathway Enrichment Analysis Protein-Protein Interaction Analysis

Study Report

Study Information

Basic Info

Reference	Goenjian, A. K.,2012 PMID: 22483952
Citation	Goenjian, A. K., et al. (2012). "Association of TPH1, TPH2, and 5HTTLPR with PTSD and depressive symptoms." J Affect Disord 140(3): 244-252.
Phenotype	PTSD-RI (PTSD symptoms)
Trauma	1988 Spitak earthquake
Study Design	Pedigree-based
Study Type	Candidate gene association study
Sample Size	200 adults
SNP/Marker Size	8 SNPs, 1 Variant
Predominant Ethnicity	Caucasian
Population	Armenian
Gender	79 males, 121 females
Age	No detial information (adults).

Detail Info

Sample Diagnosis	DSM-IV
Related Diagnostic Tools	An earthquake exposure profile was completed for each participant using a modified version of a DSM IV-based exposure questionnaire previously utilized in studies after disasters (Roussos et al., 2005). Posttraumatic stress symptoms were evaluated using the UCLA Posttraumatic Stress Disorder Reaction Index (PTSD-RI), a 22-item self-report scale based on DSM-IV PTSD criteria (Steinberg et al., 2004). Depressive symptoms were evaluated using the Beck Depression Inventory (BDI).
Sample Status	Participants included 200 adults exposed to the 1988 Spitak earthquake from 12 multigenerational families (3 to 5 generations).
Controls Exposed	Yes
Replication Size	None
Result Summary	RESULTS: After adjusting for age, sex, exposure and environmental variables, there was a significant association of PTSD symptoms with the 't' allele of TPH1 SNP rs2108977 (P-value<0.004), explaining 3% of the phenotypic variance. This allele also showed a non-significant trend for an association with depressive symptoms (P-value=0.08). Also, there was a significant association of PTSD symptoms and the 't' allele of TPH2 SNP rs11178997 (P-value=0.03), explaining 4% of the variance. Depressive symptoms were significantly associated with the 's' allele of 5HTTLPR (P-value=0.03), explaining 4% of the variance. LIMITATIONS: Retrospective rating of exposure may have been subject to memory failure leading to misestimation of symptom severities. Second, findings may not be generalizable to other ethnic/racial populations. CONCLUSION: To our knowledge, this is the first published report showing that variants in TPH1 and TPH2 genes constitute risk factors for PTSD symptoms. Additionally, the TPH1 gene may be associated pleiotropically with PTSD and depressive symptoms. The association of the 's' allele of 5HTTLPR polymorphism with depression adds to similar findings from case/case-control studies.
Potential Biomarker	None

Genetic result reported by this study

Normal genetic result reported by this study (count: 9)

Marker	Phenotype	Related Gene	Statistical Values	Author Comments	Marker's Category
rs2129575	PTSD-RI (PTSD symptoms)	TPH2	After adjusting for age, sex, exposure and environmental variables, analyses of PTSD-RI and this SNP: P-value>0.05.	The remainder of the TPH2 SNPs tested did not show a signifi...... The remainder of the TPH2 SNPs tested did not show a significant association with PTSD-RI scores; and the linkage scores were below 1.0. More...	Non-significant
rs4290270	PTSD-RI (PTSD symptoms)	TPH2	After adjusting for age, sex, exposure and environmental variables, analyses of PTSD-RI and this SNP: P-value>0.05.	The remainder of the TPH2 SNPs tested did not show a signifi...... The remainder of the TPH2 SNPs tested did not show a significant association with PTSD-RI scores; and the linkage scores were below 1.0. More...	Non-significant
rs1799913	PTSD-RI (PTSD symptoms)	TPH1	After adjusting for age, sex, exposure and environmental variables, the family based variance component analyses of PTSD-RI with rs1799913: P-value=0.69, lod score=0.56.	No significant association was observed. No significant association was observed.	Non-significant
rs2108977	PTSD-RI (PTSD symptoms)	TPH1	After adjusting for age, sex, exposure and environmental variables, the family based variance component analyses of PTSD-RI with the 't' allele of SNP rs2108977: X²=8.44, df=1, P-value < 0.004. Lod score=1.05.	After adjusting for age, sex, exposure and environmental var...... After adjusting for age, sex, exposure and environmental variables, the family based variance component analyses revealed a significant association of PTSD-RI with the 't' allele of TPH1 SNP rs2108977. This gene explained 3% of the variance in PTSD-RI scores. More...	Significant
rs1386494	PTSD-RI (PTSD symptoms)	TPH2	After adjusting for age, sex, exposure and environmental variables, analyses of PTSD-RI and this SNP: P-value>0.05.	The remainder of the TPH2 SNPs tested did not show a signifi...... The remainder of the TPH2 SNPs tested did not show a significant association with PTSD-RI scores; and the linkage scores were below 1.0. More...	Non-significant
rs17110747	PTSD-RI (PTSD symptoms)	TPH2	After adjusting for age, sex, exposure and environmental variables, analyses of PTSD-RI and this SNP: P-value>0.05.	The remainder of the TPH2 SNPs tested did not show a signifi...... The remainder of the TPH2 SNPs tested did not show a significant association with PTSD-RI scores; and the linkage scores were below 1.0. More...	Non-significant
rs11178997	PTSD-RI (PTSD symptoms)	TPH2	After adjusting for age, sex, exposure and environmental variables, analyses of PTSD-RI and the 't' allele of TPH2 SNP rs11178997: X²=3.87, df=1, P-value=0.03. Lod score=0.02.	After adjusting for age, sex, exposure and environmental var...... After adjusting for age, sex, exposure and environmental variables, analyses indicated a significant association of PTSD-RI and the 't' allele of TPH2 SNP rs11178997. This gene explained 4% of the variance of PTSD-RI scores. More...	Significant
5-HTTLPR	PTSD-RI (PTSD symptoms)	SLC6A4	After adjusting for age, sex, exposure and environmental variables, analyses of PTSD-RI and this variant: P-value>0.05.	There was no significant association of either 's' or 'l' al...... There was no significant association of either 's' or 'l' allele and PTSD-RI scores. More...	Non-significant
rs4570625	PTSD-RI (PTSD symptoms)	TPH2	After adjusting for age, sex, exposure and environmental variables, analyses of PTSD-RI and this SNP: P-value>0.05.	The remainder of the TPH2 SNPs tested did not show a signifi...... The remainder of the TPH2 SNPs tested did not show a significant association with PTSD-RI scores; and the linkage scores were below 1.0. More...	Non-significant