Study Report
Study Information
Basic Info
| Reference |
Thakur, G. A., 2009 PMID: 19444877
|
| Citation |
Thakur, G. A., et al. (2009). "Development and persistence of posttraumatic stress disorder and the 5-HTTLPR polymorphism." J Trauma Stress 22(3): 240-243. |
| Phenotype |
Acute PTSD, Chronic PTSD |
| Trauma |
A life-threatening motor vehicle accident |
| Study Design |
Cohort study |
| Study Type |
Candidate gene association study |
| Sample Size |
41 samples |
| SNP/Marker Size |
1 Variant |
| Predominant Ethnicity |
Caucasian |
| Population |
Not mentioned |
| Gender |
19 males and 22 females |
| Age |
SS genotype: mean age=30.5 years, SD=11.2, sl genotype: mean age=30.3 years, SD=11.6, ll genotype: mean age=36.2 years, SD=11.8 |
Detail Info
| Sample Diagnosis |
DSM-IV |
| Related Diagnostic Tools |
Peritraumatic Distress Inventory (PDI), Peritraumatic Dissociative Experiences Questionnaire (PDEQ), Clinician-Administered PTSD Scale (CAPS), Mini International Neuropsychiatric Interview (MINI), Participants underwent a complete diagnostic assessment by a master-level clinical psychologist. Eleven months later, participants were reassessed by the same clinical psychologist, blind to the participants PTSD diagnosis, using the same battery of tests. |
| Sample Status |
Participants with no prior diagnosis of PTSD who had experienced a life-threatening motor vehicle accident (n= 37) or another type of trauma (n= 4) in the previous month were recruited. |
| Controls Exposed |
NA |
| Replication Size |
None |
| Result Summary |
At Time 1, a nonsignificant trend for higher acute PTSD rate in ll homozygotes (82%) was observed compared to those with ss and sl genotypes (50%). At Time 2, higher chronic PTSD rate was found in ll homozygotes (55%) compared to those with ss and sl genotypes (20%), with an odds ratio of 4.8 (95% CI= 1.09-21.22). Contrary to previous findings, these data are suggestive of a protective role for the s allele of 5-HTTLPR in chronic PTSD. |
| Potential Biomarker |
None |
Genetic result reported by this study
Normal genetic result reported by this study (count: 2)
| Marker |
Phenotype |
Related Gene |
Statistical Values |
Author Comments |
Marker's Category |
|
5-HTTLPR
|
Acute PTSD |
SLC6A4 |
OR= 4.5, 95% CI= 0.83-24.41, P-value= 0.085 |
A non-signficant trend for participants with the ll genotype......
A non-signficant trend for participants with the ll genotype to be more at risk of developing acute PTSD compared to those with the ss and sl genotypes was observed.
More...
|
Non-significant |
|
5-HTTLPR
|
Chronic PTSD |
SLC6A4 |
OR= 4.8, 95% CI= 1.09-21.22, P-value= 0.052 |
At the 12-month assessment time, when patients with acute PT......
At the 12-month assessment time, when patients with acute PTSD who remitted were grouped with those who did not initially develop PTSD and compared to the chronic PTSD patients, the effect was stronger, whereby participants with the ss or sl genotypes were less likely to suffer from chronic PTSD as compared to the ll homozygotes.
More...
|
Non-significant |
