Study Report
Study Information
Basic Info
Reference |
Kovacic Petrovic, Z.,2016 PMID: 27525827
|
Citation |
Kovacic Petrovic, Z., et al. (2016). "No association between the serotonin transporter linked polymorphic region polymorphism and severity of posttraumatic stress disorder symptoms in combat veterans with or without comorbid depression." Psychiatry Res 244: 376-381. |
Phenotype |
PTSD severity |
Trauma |
Combat |
Study Design |
Cross-sectional study |
Study Type |
Candidate gene association study |
Sample Size |
158 cases, 167 controls |
SNP/Marker Size |
1 SNP |
Predominant Ethnicity |
Caucasian |
Population |
Croatian |
Gender |
325 males, 0 females |
Age |
Case: mean age=41.0 years,SD=7.0. Control: not mentioned. |
Detail Info
Sample Diagnosis |
DSM-IV |
Related Diagnostic Tools |
Structured Clinical Interview for DSM-IV (SCID), Hamilton Depression Rating Scale (HDRS), Clinician Administered PTSD Scale (CAPS) |
Sample Status |
Participants were male, medication-free combat veterans with chronic and current combat related PTSD. 51.4% had PTSD with comorbid depression. |
Controls Exposed |
Yes |
Replication Size |
None |
Result Summary |
No significant association was found between the severity of PTSD symptoms and 5-HTTLPR genotype. |
Potential Biomarker |
Our study did not confirm that 5-HTTLPR or platelet 5-HT concentration might be used as peripheral markers of severity of PTSD symptoms. |
Genetic result reported by this study
Normal genetic result reported by this study (count: 1)
Marker |
Phenotype |
Related Gene |
Statistical Values |
Author Comments |
Marker's Category |
5-HTTLPR
|
PTSD severity |
SLC6A4 |
X2=11.04, df=5, P-value=0.051 |
No significant association was found between the severity of......
No significant association was found between the severity of PTSD symptoms and 5-HTTLPR genotype.
More...
|
Non-significant |