PTSDgene database

Study Report

Study Information
Basic Info
Reference
Citation Valente, N. L., et al. (2011). "Candidate-gene approach in posttraumatic stress disorder after urban violence: association analysis of the genes encoding serotonin transporter, dopamine transporter, and BDNF." J Mol Neurosci 44(1): 59-67.
Phenotype PTSD
Trauma Urban violence
Study Design Case-control
Study Type Candidate gene association study
Sample Size 65 PTSD and 34 victims of violence without PTSD, and 335 in a community control group.
SNP/Marker Size 1 SNP, 2 Variants
Predominant Ethnicity Caucasian
Population Brazilian
Gender Cases (n=65):33.3% males. Controls (n=34):17.6% males. More details information about the community control group you can find at PROGENE (Genetic and Pharamcogenetics Program, University of Sao Paulo) data bank.
Age PTSD+: mean age=37.9 years (SD=8.7); PTSD-: mean age=44 years (SD=13.8). More details information about the community control group you can find at PROGENE (Genetic and Pharamcogenetics Program, University of S?o Paulo) data bank.

Detail Info

Genetic result reported by this study
Normal genetic result reported by this study (count: 3)
Marker Phenotype Related Gene Statistical Values Author Comments Marker's Category
5-HTTLPR PTSD SLC6A4 Chi-square test. PTSD+, PTSD?, and community control groups: genotype: P-value= 0.27 We did not find statistically significant difference son gen...... We did not find statistically significant difference son genotypic and allelic frequencies of the short/long variants of serotonin transporter gene on PTSD+ and PTSD? groups and community control group. More... Non-significant
DAT_3'UTR_VNTR PTSD SLC6A3 Between PTSD+, PTSD?, and community control groups: P-value=0.028, between PTSD+ and community control group: genotype: P-value=0.008, allele: P-value=0.004, between PTSD+ and PTSD?: P-value=0.3. For the DAT1 3'UTR VNTR, a difference was found between PTSD...... For the DAT1 3'UTR VNTR, a difference was found between PTSD+, PTSD?, and community control group. Between PTSD+ and community control group, a difference was found regarding allelic frequencies and genetic frequencies. When comparing PTSD+ and PTSD? groups, no statistical difference was observed. More... Significant
rs6265 PTSD BDNF Chi-square test. PTSD+, PTSD?, and community control groups: genotype: P-value= 0.65 We did not find statistically significant difference son gen...... We did not find statistically significant difference son genotypic and allelic frequencies of the BDNF met/val polymorphism on PTSD+ and PTSD? groups and community control group. More... Non-significant