Study Report
Study Information
Basic Info
| Reference |
Valente, N. L.,2011 PMID: 21491204
|
| Citation |
Valente, N. L., et al. (2011). "Candidate-gene approach in posttraumatic stress disorder after urban violence: association analysis of the genes encoding serotonin transporter, dopamine transporter, and BDNF." J Mol Neurosci 44(1): 59-67. |
| Phenotype |
PTSD |
| Trauma |
Urban violence |
| Study Design |
Case-control |
| Study Type |
Candidate gene association study |
| Sample Size |
65 PTSD and 34 victims of violence without PTSD, and 335 in a community control group. |
| SNP/Marker Size |
1 SNP, 2 Variants |
| Predominant Ethnicity |
Caucasian |
| Population |
Brazilian |
| Gender |
Cases (n=65):33.3% males. Controls (n=34):17.6% males. More details information about the community control group you can find at PROGENE (Genetic and Pharamcogenetics Program, University of Sao Paulo) data bank. |
| Age |
PTSD+: mean age=37.9 years (SD=8.7); PTSD-: mean age=44 years (SD=13.8). More details information about the community control group you can find at PROGENE (Genetic and Pharamcogenetics Program, University of S?o Paulo) data bank. |
Detail Info
| Sample Diagnosis |
DSM-IV |
| Related Diagnostic Tools |
The interview was administered to all patients by a trained psychiatrist. The Structured Clinical Interview for DSM-IV Axis I and Axis II (SCID-I and -II; Spitzer et al. 1992);Clinician Administered PTSD Scale (CAPS);Beck Anxiety Inventory (BAI);Beck Depression Inventory (BDI); Early Trauma Inventory (ETI). |
| Sample Status |
The presence of lifetime history of bipolar disorder, psychotic disorders, and the presence of substance dependence or abuse disorders (excluding nicotine and caffeine) in the previous 6 months were exclusion criteria. The community control group consisted of 335 subjects from the PROGENE (Genetic and Pharamcogenetics Program, University of S?o Paulo) data bank. |
| Controls Exposed |
VA |
| Replication Size |
None |
| Result Summary |
We did not find a statistical significant difference between the BDNF val66met and 5-HTTPRL polymorphism and the traumatic phenotype. However, a statistical association was found between DAT1 3'UTR VNTR nine repeats and PTSD (OR= 1.82; 95% CI: 1.20-2.76). This preliminary result confirms previous reports supporting a susceptibility role for allele 9 and PTSD. |
| Potential Biomarker |
None |
Genetic result reported by this study
Normal genetic result reported by this study (count: 3)
| Marker |
Phenotype |
Related Gene |
Statistical Values |
Author Comments |
Marker's Category |
|
5-HTTLPR
|
PTSD |
SLC6A4 |
Chi-square test. PTSD+, PTSD?, and community control groups: genotype: P-value= 0.27 |
We did not find statistically significant difference son gen......
We did not find statistically significant difference son genotypic and allelic frequencies of the short/long variants of serotonin transporter gene on PTSD+ and PTSD? groups and community control group.
More...
|
Non-significant |
|
DAT_3'UTR_VNTR
|
PTSD |
SLC6A3 |
Between PTSD+, PTSD?, and community control groups: P-value=0.028, between PTSD+ and community control group: genotype: P-value=0.008, allele: P-value=0.004, between PTSD+ and PTSD?: P-value=0.3. |
For the DAT1 3'UTR VNTR, a difference was found between PTSD......
For the DAT1 3'UTR VNTR, a difference was found between PTSD+, PTSD?, and community control group. Between PTSD+ and community control group, a difference was found regarding allelic frequencies and genetic frequencies. When comparing PTSD+ and PTSD? groups, no statistical difference was observed.
More...
|
Significant |
|
rs6265
|
PTSD |
BDNF |
Chi-square test. PTSD+, PTSD?, and community control groups: genotype: P-value= 0.65 |
We did not find statistically significant difference son gen......
We did not find statistically significant difference son genotypic and allelic frequencies of the BDNF met/val polymorphism on PTSD+ and PTSD? groups and community control group.
More...
|
Non-significant |
