Study Report
Study Information
Basic Info
| Reference |
Olsson, A.,2015 PMID: 25338633
|
| Citation |
Olsson, A., et al. (2015). "Neural and genetic markers of vulnerability to post-traumatic stress symptoms among survivors of the World Trade Center attacks." Soc Cogn Affect Neurosci 10(6): 863-868. |
| Phenotype |
PTSS scores |
| Trauma |
9/11 terrorist attack |
| Study Design |
Case-control |
| Study Type |
Candidate gene association study |
| Sample Size |
17 survivors |
| SNP/Marker Size |
1 Variant |
| Predominant Ethnicity |
Caucasian, Mongloid |
| Population |
16 European American and 1 Asian |
| Gender |
9 males, 8 females |
| Age |
Mean age=45.6 years, SD=12. |
Detail Info
| Sample Diagnosis |
DSM-III-R |
| Related Diagnostic Tools |
Post-traumatic Stress Disorder Symptoms Scale (PSS-SR) |
| Sample Status |
PTSS was assessed at three time points: 7 months following the attack (wave 1), 18 months after the attack (wave 2) and 6 years after the attack (wave 3: at the time of this experiment). |
| Controls Exposed |
Yes |
| Replication Size |
None |
| Result Summary |
Three key findings are reported. First, carriers of the short allele displayed higher levels of PTSS. Second, both PTSS and the presence of the short allele correlated negatively with activity in a network of cortical midline regions (e.g. the retrosplenal and more posterior cingulate cortices (PCCs)) implicated in episodic memories and self-reflection when viewing 9/11 vs non-9/11 negative control images. Finally, exploratory analyses indicated that PCC activity mediated the relationship between genotype and PTSS. These results highlight the role of PCC in distress following trauma. |
| Potential Biomarker |
Their findings suggest that PCC may play a role as an endophenotype for PTSD. |
Genetic result reported by this study
Normal genetic result reported by this study (count: 1)
| Marker |
Phenotype |
Related Gene |
Statistical Values |
Author Comments |
Marker's Category |
|
5-HTTLPR
|
PTSS scores |
SLC6A4 |
t(16) = 3.45, P-value=0.003, d=1.73 |
PTSS scores were significantly related to the 5-HTT genotype......
PTSS scores were significantly related to the 5-HTT genotype. The 9/11 survivors carrying the low expressive short allele (n=11) were characterized by significantly higher levels of PTSS than 9/11 survivors with the long homozygote version of the allele (n=6).
More...
|
Significant |
