Study Report

Study Information

Basic Info

Reference	Nelson, E. C.,2014 PMID: 23647975
Citation	Nelson, E. C., et al. (2014). "PTSD risk associated with a functional DRD2 polymorphism in heroin-dependent cases and controls is limited to amphetamine-dependent individuals." Addict Biol 19(4): 700-707.
Phenotype	PTSD
Trauma	Combat
Study Design	Cross-sectional study
Study Type	Candidate gene association study
Sample Size	1343 heroin dependent cases and 406 controls
SNP/Marker Size	1,430 SNPs
Predominant Ethnicity	Caucasian
Population	Australian
Gender	Heroin dependent cases: 61.1% males, 38.9% females, control: 47.5% males, 52.5% females
Age	Heroin dependent cases: mean age=36.6 years, SD=8.5; controls: mean age=35.5 years, SD=10.5

Detail Info

Sample Diagnosis	DSM-IV
Related Diagnostic Tools	Semi-Structured Assessment for the Genetics of Alcoholism - Australia (SSAGA-OZ), National Comorbidity Survey (NCS), The Barratt Impulsiveness Scale (BIS), International Personality Disorder Examination (IPDE), All interviews were conducted in person by experienced trained interviewers.
Sample Status	Data reported here include only those individuals (N=1749) who endorsed at least one form of trauma exposure in the interview's PTSD section.
Controls Exposed	NA
Replication Size	None
Result Summary	We found a functional DRD2 promoter polymorphism (rs12364283) to be most highly associated with PTSD liability; however, this association was not significant with a stringent Bonferroni correction for multiple comparisons. The top hits include SNPs from other dopaminergic system genes: DRD2 DRD3, TH, and DBH. Additional analyses revealed the association involving rs12364283 is largely limited to amphetamine dependent individuals.
Potential Biomarker	None

Genetic result reported by this study

Normal genetic result reported by this study (count: 20)

Marker	Phenotype	Related Gene	Statistical Values	Author Comments	Marker's Category
rs7929974	PTSD	ARRB1	P-value=0.0054, OR=0.82	Although the association of this SNP is of considerably lowe...... Although the association of this SNP is of considerably lower magnitude, it is interesting to note. More...	Non-significant
rs265983	PTSD	Intergenic	P-value=0.015, OR=0.82	Although the association of this SNP is of considerably lowe...... Although the association of this SNP is of considerably lower magnitude, it is interesting to note. More...	Non-significant
rs12592749	PTSD	GABRG3	P-value=0.012, OR=1.39	Although the association of this SNP is of considerably lowe...... Although the association of this SNP is of considerably lower magnitude, it is interesting to note. More...	Non-significant
rs12805897	PTSD	DRD2	P-value=0.00029, OR=1.63	The association observed for rs12805897 is likely due to its...... The association observed for rs12805897 is likely due to its high linkage disequilibrium with rs12364283. More...	Non-significant
rs2519154	PTSD	DBH	P-value=0.016, OR=0.84	Although the association of this SNP is of considerably lowe...... Although the association of this SNP is of considerably lower magnitude, it is interesting to note. More...	Non-significant
rs6787134	PTSD	DRD3	P-value=0.0088, OR=0.80	Although the association of this SNP is of considerably lowe...... Although the association of this SNP is of considerably lower magnitude, it is interesting to note. More...	Non-significant
rs6869645	PTSD	SLC6A3	P-value=0.0076, OR=1.22	Although the association of this SNP is of considerably lowe...... Although the association of this SNP is of considerably lower magnitude, it is interesting to note. More...	Non-significant
rs1245119	PTSD	NCAM1	P-value=0.011, OR=1.22	Although the association of this SNP is of considerably lowe...... Although the association of this SNP is of considerably lower magnitude, it is interesting to note. More...	Non-significant
rs4648317	PTSD	DRD2	P-value=0.018, OR=1.26	Although the association of this SNP is of considerably lowe...... Although the association of this SNP is of considerably lower magnitude, it is interesting to note. More...	Non-significant
rs12364283	PTSD	DRD2	P-value=0.00014, OR=1.66. In only amphetamine dependent samples: OR=2.86, 95%CI: 1.92-4.27; P-value=2.6E-07	The SNP most strongly associated with PTSD is rs12364283. Ho...... The SNP most strongly associated with PTSD is rs12364283. However, this association was not significant with a stringent Bonferroni correction for multiple comparisons. Additional analyses revealed the association involving rs12364283 is largely limited to amphetamine dependent individuals. More...	Significant
rs12147956	PTSD	NRXN3	P-value=0.019, OR=0.75	Although the association of this SNP is of considerably lowe...... Although the association of this SNP is of considerably lower magnitude, it is interesting to note. More...	Non-significant
rs3859123	PTSD	GRIN2A	P-value=0.014, OR=1.20	Although the association of this SNP is of considerably lowe...... Although the association of this SNP is of considerably lower magnitude, it is interesting to note. More...	Non-significant
rs6589363	PTSD	NCAM1	P-value=0.0097, OR=1.25	Although the association of this SNP is of considerably lowe...... Although the association of this SNP is of considerably lower magnitude, it is interesting to note. More...	Non-significant
rs17794760	PTSD	TPH1	P-value=0.017, OR=1.25	Although the association of this SNP is of considerably lowe...... Although the association of this SNP is of considerably lower magnitude, it is interesting to note. More...	Non-significant
rs9933111	PTSD	GRIN2A	P-value=0.015, OR=1.35	Although the association of this SNP is of considerably lowe...... Although the association of this SNP is of considerably lower magnitude, it is interesting to note. More...	Non-significant
rs7200719	PTSD	GRIN2A	P-value=0.014, OR=1.35	Although the association of this SNP is of considerably lowe...... Although the association of this SNP is of considerably lower magnitude, it is interesting to note. More...	Non-significant
rs7604404	PTSD	ITGA6	P-value=0.0063, OR=0.76	Although the association of this SNP is of considerably lowe...... Although the association of this SNP is of considerably lower magnitude, it is interesting to note. More...	Non-significant
rs10845847	PTSD	GRIN2B	P-value=0.017, OR=0.84	Although the association of this SNP is of considerably lowe...... Although the association of this SNP is of considerably lower magnitude, it is interesting to note. More...	Non-significant
rs10840491	PTSD	TH	P-value=0.0012, OR=1.39	The only other SNP with an association within an order of ma...... The only other SNP with an association within an order of magnitude of the strongest observed signal is rs10840491 located in the tyrosine hydroxylase (TH) gene. More...	Non-significant
rs10840490	PTSD	TH	P-value=0.0029, OR=1.35	Although the association of this SNP is of considerably lowe...... Although the association of this SNP is of considerably lower magnitude, it is interesting to note. More...	Non-significant