PTSDgene database

Pathway Enrichment Analysis Protein-Protein Interaction Analysis

Study Report

Study Information

Basic Info

Reference	Voisey, J.,2009 PMID: 18833581
Citation	Voisey, J., et al. (2009). "The DRD2 gene 957C>T polymorphism is associated with posttraumatic stress disorder in war veterans." Depress Anxiety 26(1): 28-33.
Phenotype	PTSD
Trauma	Vietnam combat
Study Design	Case-control
Study Type	Candidate gene association study
Sample Size	127 cases, 228 controls
SNP/Marker Size	3 SNPs
Predominant Ethnicity	Caucasian
Population	Australian
Gender	Not mentioned
Age	Not mentioned

Detail Info

Genetic result reported by this study

Normal genetic result reported by this study (count: 3)

Marker	Phenotype	Related Gene	Statistical Values	Author Comments	Marker's Category
rs1799732	PTSD	DRD2	Allele frequencies: X²= 0.71, P-value= 0.40, Odd's ratio (95% CI): 0.78(0.42-1.42), Genotype frequencies: Likelihood-ratio chi-square test: X²= 0.74, P-value= 0.691	No association with PTSD was observed for rs1799732 polymorp...... No association with PTSD was observed for rs1799732 polymorphisms at the allele or genotype level. More...	Non-significant
rs1800497	PTSD	DRD2	Allele frequencies: X²= 2.80, P-value= 0.094, Odd's ratio (95% CI): 1.39(0.93-2.07), Genotype frequencies: Likelihood-ratio chi-square test: X²= 3.67, P-value= 0.160, Mantel-Haenszel chi-square test for trend: X²=2.79, P-value=0.095	No association with PTSD was observed for rs1800497 polymorp...... No association with PTSD was observed for rs1800497 polymorphisms at the allele or genotype level. More...	Non-significant
rs6277	PTSD	DRD2	Allele frequencies: X²= 5.34, P-value= 0.021, Odd's ratio (95% CI): 1.45(1.04-2.01), Genotype frequencies: Likelihood-ratio chi-square test: X²= 5.37, P-value= 0.068, Mantel-Haenszel chi-square test for trend: X²=5.33, P-value=0.021	A significant trend in susceptibility to PTSD was found with...... A significant trend in susceptibility to PTSD was found with respect to increasing C alleles in genotypes. The odds of an individual with PTSD having the CC genotype (rather than the TT genotype) are twice that of the controls. The analysis revealed that 14% of the susceptibility to PTSD could be attributed to having the CC genotype of rs6277 DRD2 polymorphism. More...	Significant