Study Report
Study Information
Basic Info
| Reference |
Gelernter, J.,1999 PMID: 10088049
|
| Citation |
Gelernter, J., et al. (1999). "No association between D2 dopamine receptor (DRD2) "A" system alleles, or DRD2 haplotypes, and posttraumatic stress disorder." Biol Psychiatry 45(5): 620-625. |
| Phenotype |
PTSD diagnosis |
| Trauma |
Vietnam combat |
| Study Design |
Case-control |
| Study Type |
Candidate gene association study |
| Sample Size |
52 cases, 87 controls |
| SNP/Marker Size |
1 SNP,1 Variant |
| Predominant Ethnicity |
Caucasian |
| Population |
European American |
| Gender |
Not mentioned |
| Age |
Case: mean age=44.6 years, SD=3.6. Control: not mentioned |
Detail Info
| Sample Diagnosis |
Not mentioned |
| Related Diagnostic Tools |
Consensus diagnoses were made on the basis of structured clinical interviews (SCID (Spitzer et al 1992) or SADS-L (Spitzer and Endicott 1975)) and clinical evaluations by psychologists and psychiatrists specializing in PTSD. |
| Sample Status |
Of those subjects with PTSD, 38 (93%) had diagnoses of either alcohol or substance dependence, or both (alcohol dependence, 31; substance dependence, 25). |
| Controls Exposed |
Yes |
| Replication Size |
None |
| Result Summary |
Frequency of the A1 allele in this sample was 0.15, not significantly different from the 0.19 allele frequency seen in 87 control subjects. We were thus unable to replicate the previous reports of allelic association between the DRD2 TaqI "A1" allele and PTSD. There were also no significant differences in allele frequency for the "B" or "D" systems. We then computed three marker (TaqI "A","B", and "D" system) haplotypes for the sample; DRD2 haplotype frequencies also did not differ between control subjects and subjects with PTSD. |
| Potential Biomarker |
None |
Genetic result reported by this study
Normal genetic result reported by this study (count: 1)
| Marker |
Phenotype |
Related Gene |
Statistical Values |
Author Comments |
Marker's Category |
|
rs1800497
|
PTSD diagnosis |
DRD2 |
Analysis by alleles: X2=0.35, P-value=0.55; analysis by carrier: X2=0.41, P-value=0.52. |
Frequency of the A1 allele in this sample was not significan......
Frequency of the A1 allele in this sample was not significantly different from the allele frequency seen in 87 control subjects.
More...
|
Non-significant |
