Study Report
Study Information
Basic Info
| Reference |
Bailey, J. N.,2010 PMID: 20554017
|
| Citation |
Bailey, J. N., et al. (2010). "PTSD and dopaminergic genes, DRD2 and DAT, in multigenerational families exposed to the Spitak earthquake." Psychiatry Res 178(3): 507-510. |
| Phenotype |
PTSD diagnosis, PTSD symptoms and PTSD category B symptom score, PTSD category C symptom score |
| Trauma |
1988 Spitak earthquake |
| Study Design |
Cross-sectional study |
| Study Type |
Candidate gene association study |
| Sample Size |
200 samples |
| SNP/Marker Size |
1 SNP,1 Variant |
| Predominant Ethnicity |
Caucasian |
| Population |
Caucasian Armenian |
| Gender |
121 females, 79 males |
| Age |
Not mentioned |
Detail Info
| Sample Diagnosis |
DSM-IV |
| Related Diagnostic Tools |
Posttraumatic Stress Disorder Reaction Index(PTSD-RI). |
| Sample Status |
None |
| Controls Exposed |
NA |
| Replication Size |
None |
| Result Summary |
Neither the DRD2 nor the DAT polymorphisms explained the variation seen in PTSD diagnosis, total PTSD symptom severity, and categories B and C symptom severities. These findings contradict prior reports of positive associations between both DRD2 and DAT, and PTSD. |
| Potential Biomarker |
None |
Genetic result reported by this study
Normal genetic result reported by this study (count: 8)
| Marker |
Phenotype |
Related Gene |
Statistical Values |
Author Comments |
Marker's Category |
|
rs1800497
|
PTSD category B symptom score |
DRD2 |
B=0.62, P-value=0.61 |
There was no association between DRD2/A1+ allele and PTSD ca......
There was no association between DRD2/A1+ allele and PTSD category B symptom score.
More...
|
Non-significant |
|
rs1800497
|
PTSD category C symptom score |
DRD2 |
B=1.28, P-value=0.39 |
There was no association between DRD2/A1+ allele and PTSD ca......
There was no association between DRD2/A1+ allele and PTSD category C symptom score.
More...
|
Non-significant |
|
DAT_3'UTR_VNTR
|
PTSD symptoms |
SLC6A3 |
B=-1.14, P-value=0.87 |
There was no association between DAT/9 repeat allele and PTS......
There was no association between DAT/9 repeat allele and PTSD diagnosis.
More...
|
Non-significant |
|
rs1800497
|
PTSD diagnosis |
DRD2 |
X2=0.35, P-value=0.56, after controlling for alcohol dependency: B=?3.36, P-value=0.44 |
There was no association between DRD2/A1+ allele and PTSD di......
There was no association between DRD2/A1+ allele and PTSD diagnosis.
More...
|
Non-significant |
|
DAT_3'UTR_VNTR
|
PTSD diagnosis |
SLC6A3 |
X2=2.6, P-value=0.11, after controlling for alcohol dependency: B=?2.44, P-value=0.65 |
There was no association between DAT/9 repeat allele and PTS......
There was no association between DAT/9 repeat allele and PTSD diagnosis.
More...
|
Non-significant |
|
rs1800497
|
PTSD symptoms |
DRD2 |
B=1.92, P-value=0.44 |
There was no association between DRD2/A1+ allele and total P......
There was no association between DRD2/A1+ allele and total PTSD-RI scores.
More...
|
Non-significant |
|
DAT_3'UTR_VNTR
|
PTSD category B symptom score |
SLC6A3 |
B=-1.23, P-value=0.35 |
There was no association between DAT/9 repeat allele and PTS......
There was no association between DAT/9 repeat allele and PTSD diagnosis.
More...
|
Non-significant |
|
DAT_3'UTR_VNTR
|
PTSD category C symptom score |
SLC6A3 |
B=-0.50, P-value=0.72 |
There was no association between DAT/9 repeat allele and PTS......
There was no association between DAT/9 repeat allele and PTSD diagnosis.
More...
|
Non-significant |
