Study Report
Study Information
Basic Info
| Reference |
Young, R. M.,2002 PMID: 12217937
|
| Citation |
Young, R. M., et al. (2002). "Harmful drinking in military veterans with post-traumatic stress disorder: association with the D2 dopamine receptor A1 allele." Alcohol Alcohol 37(5): 451-456. |
| Phenotype |
PTSD |
| Trauma |
Various |
| Study Design |
Case-control |
| Study Type |
Candidate gene association study |
| Sample Size |
91 cases, 51 controls |
| SNP/Marker Size |
1 Variant |
| Predominant Ethnicity |
Caucasian |
| Population |
Australian |
| Gender |
Case: No detail information, Control: 18 males and 33 females |
| Age |
Case: mean age=50.2 years,SD=0.7, Control: mean age=38.9 years,SD=1.9 |
Detail Info
| Sample Diagnosis |
DSM-IV |
| Related Diagnostic Tools |
Mississippi Scale for Combat-Related Posttraumatic Stress Disorder, Patients were assessed for PTSD using DSM-IV criteria by a consultant psychiatrist (B.L.) or a senior psychiatric registrar (B.K.). In addition, patients had a psychiatric history taken (B.L or B.K.) or were assessed by a clinical nurse (A.W.). |
| Sample Status |
The amount of alcohol consumed was converted to grams of pure ethanol per day. Rate of alcohol consumed during each dringking occasion in the past 12 months was also ascertained and expressed as grams of pure ethanol per hour, In addition, patients' use of cigarettes and illicit drugs was obtained, as well as first-degree family history of alcoholism. |
| Controls Exposed |
NS |
| Replication Size |
None |
| Result Summary |
In 91 PTSD patients, the frequency of the A1 allele was higher (P-value= 6.12E-03) than in the 51 controls. In the 38 PTSD harmful drinkers (>=60 g alcohol/day), A1 allelic frequency was higher (P-value= 3.91E-02) than in the 53 non-harmful drinkers (<60 g alcohol/day), the former being also higher (P-value= 3.76E-04) than in controls. However, there was no difference between non-harmful drinkers and controls. Based on DRD2 allelic association, the 35 PTSD patients with the A1+ (A1A1, A1A2) allele consumed more than twice the daily amount of alcohol than the 56 patients with the A1? (A2A2) allele (P-value= 1.94 E-03). When the hourly rate of alcohol consumed was compared, A1+ allelic patients consumed twice the rate of the A1? allelic patients (P-value< E-07). In conclusion, the DRD2 A1+ allele in servicemen with PTSD is associated with markedly more persistent and harmful drinking behaviour than in servicemen without this allele. The increased DRD2 A1+ allelic frequency found in PTSD veterans was not independent of drinking behaviour. |
| Potential Biomarker |
None |
Genetic result reported by this study
Normal genetic result reported by this study (count: 1)
| Marker |
Phenotype |
Related Gene |
Statistical Values |
Author Comments |
Marker's Category |
|
DRD2_Taq I A alleles
|
PTSD |
DRD2 |
The frequency of the A1 allele: PTSD group vs control group: X2= 7.51, P-value= 6.12E-03 |
The DRD2 A1 allele was associated with PTSD. However, this a......
The DRD2 A1 allele was associated with PTSD. However, this association was found only in the harmful drinkers. It is also possible that the greater alcohol use by DRD2 A1+ allelic patients may have a deleterious effect on PTSD symptoms and the course of this disorder. The increased DRD2 A1+ allelic frequency found in PTSD veterans was not independent of drinking behaviour.
More...
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Significant |
