PTSDgene database

Study Report

Study Information
Basic Info
Citation Young, R. M., et al. (2002). "Harmful drinking in military veterans with post-traumatic stress disorder: association with the D2 dopamine receptor A1 allele." Alcohol Alcohol 37(5): 451-456.
Phenotype PTSD
Trauma Various
Study Design Case-control
Study Type Candidate gene association study
Sample Size 91 cases, 51 controls
SNP/Marker Size 1 Variant
Predominant Ethnicity Caucasian
Population Australian
Gender Case: No detail information, Control: 18 males and 33 females
Age Case: mean age=50.2 years,SD=0.7, Control: mean age=38.9 years,SD=1.9

Detail Info

Genetic result reported by this study
Normal genetic result reported by this study (count: 1)
Marker Phenotype Related Gene Statistical Values Author Comments Marker's Category
DRD2_Taq I A alleles PTSD DRD2 The frequency of the A1 allele: PTSD group vs control group: X2= 7.51, P-value= 6.12E-03 The DRD2 A1 allele was associated with PTSD. However, this a...... The DRD2 A1 allele was associated with PTSD. However, this association was found only in the harmful drinkers. It is also possible that the greater alcohol use by DRD2 A1+ allelic patients may have a deleterious effect on PTSD symptoms and the course of this disorder. The increased DRD2 A1+ allelic frequency found in PTSD veterans was not independent of drinking behaviour. More... Significant