PTSDgene database

Pathway Enrichment Analysis Protein-Protein Interaction Analysis

Study Report

Study Information

Basic Info

Reference	Comings, D. E.,1996 PMID: 8874837
Citation	Comings, D. E., et al. (1996). "Dopamine D2 receptor (DRD2) gene and susceptibility to posttraumatic stress disorder: a study and replication." Biol Psychiatry 40(5): 368-372.
Phenotype	PTSD diagnosis, Reexperiencing of the traumatic events, Avoidance of trauma-associated stimuli, Increased hyperreactivity and vigilance, Total PTSD score
Trauma	Combat
Study Design	Case-control
Study Type	Candidate gene association study
Sample Size	37 cases, 19 controls
SNP/Marker Size	1 SNP
Predominant Ethnicity	Caucasian
Population	Non-Hispanic whites
Gender	Not mentioned
Age	Mean age= 43.6 years

Detail Info

Sample Diagnosis	DSM-III-R
Related Diagnostic Tools	Not mentioned
Sample Status	All subjects also met DSM-IIIR criteria for either alcohol or drug dependence. Subjects were excluded from the study if they had a history of or met DSM-IIIR criteria for psychoses.
Controls Exposed	Yes
Replication Size	None
Result Summary	Of 24 with PTSD, 58.3% carried the D2Al allele. Of the remaining eight who did not meet PTSD criteria, 12.5% carried the D2Al allele (P-value= 0.04). In a replication study of 13 with PTSD, 61.5% carried the D2A1 allele. Of the remaining 11 who did not meet criteria for PTSD, 0% carried the DeAl allele (P-value= 0.002). For the combined group 59.5% of those with PTSD carried the DeAl allele versus 5.3% of those who did not have PTSD (P-value= 0.0001). These results suggest that a DRD2 variant in linkage disequilibrium with the D2Al allele confers an increased risk to PTSD, and the absence of the variant confers a relative resistance to PTSD.
Potential Biomarker	None

Genetic result reported by this study

Normal genetic result reported by this study (count: 5)

Marker	Phenotype	Related Gene	Statistical Values	Author Comments	Marker's Category
rs1800497	Avoidance of trauma-associated stimuli	DRD2	F=10.92,P-value=0.0017	All three subscores were significantly higher in the D2A1 ca...... All three subscores were significantly higher in the D2A1 carriers than the D2A2A3 homozygotes, avoidance of trauma-associated stimuli remained significant following a Bonferonni correction for multiple comparisons requiring a P-value of 0.05/4. More...	Significant
rs1800497	Total PTSD score	DRD2	F=15.89,P-value=0.0002	Total PTSD score remained significant following a Bonferonni...... Total PTSD score remained significant following a Bonferonni correction for multiple comparisons requiring a P-value of 0.05/4. More...	Significant
rs1800497	Increased hyperreactivity and vigilance	DRD2	F=23.43,P-value <0.0001	All three subscores were significantly higher in the D2A1 ca...... All three subscores were significantly higher in the D2A1 carriers than the D2A2A4 homozygotes, increased hyperreactivity and vigilance remained significant following a Bonferonni correction for multiple comparisons requiring a P-value of 0.05/4. More...	Significant
rs1800497	PTSD diagnosis	DRD2	X²=15.23, P-value=0.00010	For the total group, of those who meet criteria, 59.5% carri...... For the total group, of those who meet criteria, 59.5% carried the D2A1 allele versus 5.3% of those who did not meet criteria. More...	Significant
rs1800497	Reexperiencing of the traumatic events	DRD2	F=5.34,P-value=0.025	All three subscores were significantly higher in the D2A1 ca...... All three subscores were significantly higher in the D2A1 carriers than the D2A2A2 homozygotes. More...	Significant