PTSDgene database

SNP Report

Basic Info
Name rs2075652 dbSNP Ensembl
Location 11:113424176 - 113424176(+)
Variant Seq A
Ancestral Allele G
Ref Seq G
Minor Allele Frequence 0.106629
Annotation downstream_gene_variant; intron_variant; non_coding_transcript_variant
Variant Effect downstream_gene_variant(ENST00000542616); intron_variant(ENST00000535984, ENST00000540600, ENST00000542968, ENST00000543292, ENST00000346454, ENST00000362072, ENST00000538967, ENST00000544518); non_coding_transcript_variant(ENST00000535984, ENST00000540600)
SIFT Annotation tolerated_-_low_confidence; tolerated
SIFT Variant Effect tolerated_-_low_confidence(ENST00000362072, ENST00000542968, ENST00000538967, ENST00000544518); tolerated(ENST00000543292, ENST00000346454)
PolyPhen Annotation benign
PolyPhen Variant Effect benign(ENST00000543292, ENST00000362072, ENST00000542968, ENST00000346454, ENST00000538967, ENST00000544518)
rSNP? Yes Link in rVarBase
Related Regulatory Elements n/a
Chromatin State Weak transcription
No. of Marker's Association Results 1 (Positive: 1; Negative: 0; Trend: 0)
Source Literature

SNP related association results
Normal genetic study related association results (count: 1)
Reference Phenotype Statistical Values Author Comments Marker's Category
Duan, Z.,2015 PTSD diagnosis Allele dose analysis model: P-value=0.048; Dominant effect:...... Allele dose analysis model: P-value=0.048; Dominant effect: P-value=0.02; Recessive effect: P-value=0.70 More... Rs2075652 was significantly associated with the risk of PTSD...... Rs2075652 was significantly associated with the risk of PTSD in all allele dose analysis models, in dominant effect, when compared with rs2075652 GG genotypes, the combined genotypes rs2075652 AA/GA had a significantly increased effect on PTSD risk. More... Significant

SNP related genes (count: 1)
Approved Symbol Approved Name Location No. of Association Results (Positive/Negative/Trend)
DRD2 dopamine receptor D2 11q23.2 18(11/7/0)

SNPs in LD with rs2075652 (count: 2)
The LD data used here is based on 1000 Genome Phase I. LD SNP pairs were selected with a threshold r2<=0.8.

Literature-origin SNPs (count: 0)

LD-proxies (count: 2)

SNP related eQTL (count: 1)
Gene Symbol Gene Existed in PTSDgene? Tissue Trans/Cis Source
LRRC37A4P No Adipose Subcutaneous cis GTEx