PTSDgene database

Pathway Enrichment Analysis Protein-Protein Interaction Analysis

Study Report

Study Information

Basic Info

Reference	Duan, Z.,2015 PMID: 26363619
Citation	Duan, Z., et al. (2015). "Assessment of functional tag single nucleotide polymorphisms within the DRD2 gene as risk factors for post-traumatic stress disorder in the Han Chinese population." J Affect Disord 188: 210-217.
Phenotype	PTSD diagnosis
Trauma	Various
Study Design	Case-control
Study Type	Candidate gene association study
Sample Size	337 cases, 497 controls
SNP/Marker Size	15 SNPs
Predominant Ethnicity	Mongloid
Population	Chinese Han
Gender	Case: 222 females, 115 males. Control: 199 females, 298 males
Age	Case: mean age=38.70 years, SD=7.90. Control: mean age=34.50 years, SD=5.30

Detail Info

Sample Diagnosis	DSM-IV
Related Diagnostic Tools	The UCLA Posttraumatic Stress Disorder Reaction Index (PTSD-RI), the Structured Clinical Interview for DSM-IV Axis-I disorders Patient Version (SCID-I/P).
Sample Status	Patients were excluded if other major Axis I diagnoses (excepting major depression) were present, such as bipolar disorder, schizophrenia or other psychotic disorders, and alcohol or substance abuse during the past 6 months. Patients were also excluded if there were any medical or psychiatric conditions, including pregnancy and lactation that could pose health risks during the course of the study.
Controls Exposed	NS
Replication Size	None
Result Summary	Fifteen tag SNPs were identified in the Han Chinese population and all were common SNPs. Among 15 tSNPs, two of them significantly associated with PTSD. PTSD individuals were more likely to carry the rs2075652A and rs7131056A allele compared to the controls. The haplotype GTGATCGCGCAGGCG, had a risk effect on PTSD occurrence. Additionally, the rs2075652 polymorphism contained intronic enhancer activities.
Potential Biomarker	None

Genetic result reported by this study

Normal genetic result reported by this study (count: 19)

Marker	Phenotype	Related Gene	Statistical Values	Author Comments	Marker's Category
rs7131056	PTSD diagnosis	DRD2	Allele dose analysis model: P-value=0.04; Dominant effect: P-value=0.02; Recessive effect: P-value=0.18	Rs7131056 was significantly associated with the risk of PTSD...... Rs7131056 was significantly associated with the risk of PTSD in all allele dose analysis models, in dominant effect, compared with rs7131056 CC genotypes, the combined genotypes rs7131056 AA/AC had a significantly increased PTSD risk. More...	Significant
rs10891556	PTSD diagnosis	DRD2	Allele dose analysis model: P-value=0.41; Dominant effect: P-value=0.42; Recessive effect: P-value=0.24.	No significant results. No significant results.	Non-significant
rs12574471	PTSD diagnosis	DRD2	Allele dose analysis model: P-value=0.12; Dominant effect: P-value=0.06; Recessive effect: P-value=0.27.	No significant results. No significant results.	Non-significant
rs2242591	PTSD diagnosis	DRD2	Allele dose analysis model: P-value=0.32; Dominant effect: P-value=0.27; Recessive effect: P-value=0.23.	No significant results. No significant results.	Non-significant
rs6279	PTSD diagnosis	DRD2	Allele dose analysis model: P-value=0.29; Dominant effect: P-value=0.32; Recessive effect: P-value=0.15.	No significant results. No significant results.	Non-significant
rs4648319	PTSD diagnosis	DRD2	Allele dose analysis model: P-value=0.67; Dominant effect: P-value=0.94; Recessive effect: P-value=0.45.	No significant results. No significant results.	Non-significant
rs10891556 - rs1799978 - rs4648317 - rs7131056 - rs4460839 - rs12574471 - rs4648319 - rs4648318 - rs4586205 - rs4436578 - rs2075652 - rs2734833 - rs6279 - rs2242591 - rs1800479, TTACTCGCGCAGGCG	PTSD diagnosis	DRD2	X²=0.67, P-value= 0.41	No significant results. No significant results.	Non-significant
rs4648318	PTSD diagnosis	DRD2	Allele dose analysis model: P-value=0.42; Dominant effect: P-value=1.00; Recessive effect: P-value=0.23.	No significant results. No significant results.	Non-significant
rs10891556 - rs1799978 - rs4648317 - rs7131056 - rs4460839 - rs12574471 - rs4648319 - rs4648318 - rs4586205 - rs4436578 - rs2075652 - rs2734833 - rs6279 - rs2242591 - rs1800479, TTACTCATTTGGCTA	PTSD diagnosis	DRD2	X²=3.81, P-value= 0.05	No significant results. No significant results.	Non-significant
rs4586205	PTSD diagnosis	DRD2	Allele dose analysis model: P-value=0.29; Dominant effect: P-value=0.66; Recessive effect: P-value=0.12.	No significant results. No significant results.	Non-significant
rs10891556 - rs1799978 - rs4648317 - rs7131056 - rs4460839 - rs12574471 - rs4648319 - rs4648318 - rs4586205 - rs4436578 - rs2075652 - rs2734833 - rs6279 - rs2242591 - rs1800479, GTGATCATTTGGCTA	PTSD diagnosis	DRD2	X²=0.02, P-value= 0.89	No significant results. No significant results.	Non-significant
rs4648317	PTSD diagnosis	DRD2	Allele dose analysis model: P-value=0.10; Dominant effect: P-value=0.31; Recessive effect: P-value=0.04.	For the recessive effect, compared with the combined genotyp...... For the recessive effect, compared with the combined genotypes rs4648317 GA/GG, rs4648317, AA genotypes had a significantly decreased PTSD risk. More...	Significant
rs10891556 - rs1799978 - rs4648317 - rs7131056 - rs4460839 - rs12574471 - rs4648319 - rs4648318 - rs4586205 - rs4436578 - rs2075652 - rs2734833 - rs6279 - rs2242591 - rs1800479, GTGATCGCGCAGGCG	PTSD diagnosis	DRD2	X²=10.07, P-value= 0.002	Haplotype analysis showed that the haplotype, ht2 (GTGATCGCG...... Haplotype analysis showed that the haplotype, ht2 (GTGATCGCGCAGGCG), was significantly higher in patients than healthy volunteers, suggesting that ht2 had a risk effect on PTSD development. More...	Significant
rs1800479	PTSD diagnosis	DRD2	Allele dose analysis model: P-value=0.46; Dominant effect: P-value=0.42; Recessive effect: P-value=0.32.	No significant results. No significant results.	Non-significant
rs1799978	PTSD diagnosis	DRD2	Allele dose analysis model: P-value=0.61; Dominant effect: P-value=0.56; Recessive effect: P-value=0.41.	No significant results. No significant results.	Non-significant
rs4436578	PTSD diagnosis	DRD2	Allele dose analysis model: P-value=0.07; Dominant effect: P-value=0.02; Recessive effect: P-value=0.48.	Also when the dominant effect was measured, compared with rs...... Also when the dominant effect was measured, compared with rs4436578 TT genotypes, the combined genotypes rs4436578 CC/CT had a significantly increased PTSD risk. More...	Significant
rs4460839	PTSD diagnosis	DRD2	Allele dose analysis model: P-value=0.17; Dominant effect: P-value=0.37; Recessive effect: P-value=0.08.	No significant results. No significant results.	Non-significant
rs2734833	PTSD diagnosis	DRD2	Allele dose analysis model: P-value=0.48; Dominant effect: P-value=0.91; Recessive effect: P-value=0.52.	No significant results. No significant results.	Non-significant
rs2075652	PTSD diagnosis	DRD2	Allele dose analysis model: P-value=0.048; Dominant effect: P-value=0.02; Recessive effect: P-value=0.70	Rs2075652 was significantly associated with the risk of PTSD...... Rs2075652 was significantly associated with the risk of PTSD in all allele dose analysis models, in dominant effect, when compared with rs2075652 GG genotypes, the combined genotypes rs2075652 AA/GA had a significantly increased effect on PTSD risk. More...	Significant