PTSDgene database

SNP Report

Basic Info
Name rs6277 dbSNP Ensembl
Location 11:113412737 - 113412737(+)
Variant Seq A
Ancestral Allele G
Ref Seq G
Minor Allele Frequence 0.24401
Annotation synonymous_variant; downstream_gene_variant
Variant Effect synonymous_variant(ENST00000346454, ENST00000362072, ENST00000538967, ENST00000542968, ENST00000544518); downstream_gene_variant(ENST00000540600, ENST00000546284, ENST00000539420, ENST00000543292, ENST00000535984)
SIFT Annotation tolerated
SIFT Variant Effect tolerated(ENST00000544518, ENST00000362072, ENST00000538967, ENST00000346454, ENST00000542968)
PolyPhen Annotation benign
PolyPhen Variant Effect benign(ENST00000544518, ENST00000362072, ENST00000538967, ENST00000346454, ENST00000542968)
rSNP? Yes Link in rVarBase
Related Regulatory Elements n/a
Chromatin State Weak transcription
No. of Marker's Association Results 1 (Positive: 1; Negative: 0; Trend: 0)
Source Literature

SNP related association results
Normal genetic study related association results (count: 1)
Reference Phenotype Statistical Values Author Comments Marker's Category
Voisey, J.,2009 PTSD Allele frequencies: X2= 5.34, P-value= 0.021, Od...... Allele frequencies: X2= 5.34, P-value= 0.021, Odd's ratio (95% CI): 1.45(1.04-2.01), Genotype frequencies: Likelihood-ratio chi-square test: X2= 5.37, P-value= 0.068, Mantel-Haenszel chi-square test for trend: X2=5.33, P-value=0.021 More... A significant trend in susceptibility to PTSD was found with...... A significant trend in susceptibility to PTSD was found with respect to increasing C alleles in genotypes. The odds of an individual with PTSD having the CC genotype (rather than the TT genotype) are twice that of the controls. The analysis revealed that 14% of the susceptibility to PTSD could be attributed to having the CC genotype of rs6277 DRD2 polymorphism. More... Significant

SNP related genes (count: 1)
Approved Symbol Approved Name Location No. of Association Results (Positive/Negative/Trend)
DRD2 dopamine receptor D2 11q23.2 18(11/7/0)

SNPs in LD with rs6277 (count: 19)
The LD data used here is based on 1000 Genome Phase I. LD SNP pairs were selected with a threshold r2<=0.8.

Literature-origin SNPs (count: 0)

LD-proxies (count: 19)

SNP related eQTL (count: 1)
Gene Symbol Gene Existed in PTSDgene? Tissue Trans/Cis Source
LRRC37A4P No Adipose Subcutaneous cis GTEx