SNP Report

Basic Info

Name	rs6277 dbSNP Ensembl
Location	11:113412737 - 113412737(+)
Variant Seq	A
Ancestral Allele	G
Ref Seq	G
Minor Allele Frequence	0.24401
Annotation	synonymous_variant; downstream_gene_variant
Variant Effect	synonymous_variant(ENST00000346454, ENST00000362072, ENST00000538967, ENST00000542968, ENST00000544518); downstream_gene_variant(ENST00000540600, ENST00000546284, ENST00000539420, ENST00000543292, ENST00000535984)
SIFT Annotation	tolerated
SIFT Variant Effect	tolerated(ENST00000544518, ENST00000362072, ENST00000538967, ENST00000346454, ENST00000542968)
PolyPhen Annotation	benign
PolyPhen Variant Effect	benign(ENST00000544518, ENST00000362072, ENST00000538967, ENST00000346454, ENST00000542968)
rSNP?	Yes Link in rVarBase
Related Regulatory Elements	n/a
Chromatin State	Weak transcription
No. of Marker's Association Results	1 (Positive: 1; Negative: 0; Trend: 0)
Source	Literature

SNP related association results

Normal genetic study related association results (count: 1)

Reference	Phenotype	Statistical Values	Author Comments	Marker's Category
Voisey, J.,2009	PTSD	Allele frequencies: X²= 5.34, P-value= 0.021, Od...... Allele frequencies: X²= 5.34, P-value= 0.021, Odd's ratio (95% CI): 1.45(1.04-2.01), Genotype frequencies: Likelihood-ratio chi-square test: X²= 5.37, P-value= 0.068, Mantel-Haenszel chi-square test for trend: X²=5.33, P-value=0.021 More...	A significant trend in susceptibility to PTSD was found with...... A significant trend in susceptibility to PTSD was found with respect to increasing C alleles in genotypes. The odds of an individual with PTSD having the CC genotype (rather than the TT genotype) are twice that of the controls. The analysis revealed that 14% of the susceptibility to PTSD could be attributed to having the CC genotype of rs6277 DRD2 polymorphism. More...	Significant

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Association Results (Positive/Negative/Trend)
DRD2	dopamine receptor D2	11q23.2	18(11/7/0)

SNPs in LD with rs6277 (count: 19)

The LD data used here is based on 1000 Genome Phase I. LD SNP pairs were selected with a threshold r²<=0.8.

Literature-origin SNPs (count: 0)

LD-proxies (count: 19)

rs_ID	Literature-origin SNPs with LD	Annotation	r²[population]
rs34601878	rs2734833 rs6277	upstream_gene_variant; intron_variant	0.9128[EUR]
rs35023999	rs2734833 rs6277	intron_variant; NMD_transcript_variant	0.8199[EUR]
rs11214603	rs2734833 rs6277	downstream_gene_variant; intron_variant; non_coding_transcript_variant	1.0000[EUR]
rs10891547	rs2734833 rs6277	downstream_gene_variant; intron_variant	0.8163[EUR]
rs754672	rs2734833 rs6277	intron_variant	0.8144[EUR]
rs11214596	rs2734833 rs6277	intron_variant; NMD_transcript_variant	0.9125[EUR]
rs877137	rs2734833 rs6277	downstream_gene_variant; upstream_gene_variant	0.8641[EUR]
rs10891548	rs2734833 rs6277	downstream_gene_variant; intron_variant	0.8163[EUR]
rs12360992	rs2734833 rs6277	upstream_gene_variant; intron_variant	0.9174[EUR]
rs11214594	rs2734833 rs6277	intron_variant	0.9079[EUR]
rs7107223	rs6277	downstream_gene_variant; upstream_gene_variant	0.8594[EUR]
rs17600713	rs2734833 rs6277	upstream_gene_variant; intron_variant	0.9128[EUR]
rs10891544	rs2734833 rs6277	downstream_gene_variant; upstream_gene_variant	0.8641[EUR]
rs11214595	rs2734833 rs6277	upstream_gene_variant; intron_variant	0.9128[EUR]
rs2734849	rs2734833 rs6277	downstream_gene_variant; missense_variant	0.8155[EUR]
rs1554929	rs2734833 rs6277	downstream_gene_variant; intron_variant; non_coding_transcript_variant	0.9841[EUR]
rs11604671	rs2734833 rs6277	downstream_gene_variant; missense_variant	0.8076[EUR]
rs10891549	rs2734833 rs6277	downstream_gene_variant; intron_variant; non_coding_transcript_variant	0.9894[EUR]
rs7116782	rs2734833 rs6277	intron_variant	0.8437[EUR]

SNP related eQTL (count: 1)

Gene Symbol	Gene Existed in PTSDgene?	Tissue	Trans/Cis	Source
LRRC37A4P	No	Adipose Subcutaneous	cis	GTEx