Rothbaum, B. O.,2014 PMID: 25188543
||Rothbaum, B. O., et al. (2014). "Early intervention following trauma may mitigate genetic risk for PTSD in civilians: a pilot prospective emergency department study." J Clin Psychiatry 75(12): 1380-1387.
||PTSD symptoms at week 4, Diagnosis of PTSD at week 12
||Candidate gene association study
||Intervention group: 31 samples, Assessment group: 34 samples
||African American(83.1%), White, Native American, Other
||Intervention group: 15 males, 16 females, Assessment group: 10 males, 24 females
||Intervention group: mean age=31.3 years, SD=11.6, Assessment group: mean age=34.7 years, SD=11.5
Genetic result reported by this study
Normal genetic result reported by this study (count: 2)
||PTSD symptoms at week 4
||Intervention group: P-value=0.22, Assessment group: P-value=0.32
There were no significant differences at the 4-week time poi......
There were no significant differences at the 4-week time point for the intervention and the assessment groups.
||Diagnosis of PTSD at week 12
||Intervention group: X2= 5.85, P-value=0.02, Assessment group: X2= 0.04, P-value=0.84
Subjects with the risk genotype (CC) were more likely to be ......
Subjects with the risk genotype (CC) were more likely to be diagnosed with PTSD at week 12 (87.5%) compared to carriers of the low-risk allele (12.5%) if they were assessed-only, whereas there was no difference between genotype risk groups in the intervention cohort.