Study Report
Study Information
Basic Info
| Reference |
Rothbaum, B. O.,2014 PMID: 25188543
|
| Citation |
Rothbaum, B. O., et al. (2014). "Early intervention following trauma may mitigate genetic risk for PTSD in civilians: a pilot prospective emergency department study." J Clin Psychiatry 75(12): 1380-1387. |
| Phenotype |
PTSD symptoms at week 4, Diagnosis of PTSD at week 12 |
| Trauma |
Various |
| Study Design |
Case-control |
| Study Type |
Candidate gene association study |
| Sample Size |
Intervention group: 31 samples, Assessment group: 34 samples |
| SNP/Marker Size |
32 SNPs |
| Predominant Ethnicity |
Black |
| Population |
African American(83.1%), White, Native American, Other |
| Gender |
Intervention group: 15 males, 16 females, Assessment group: 10 males, 24 females |
| Age |
Intervention group: mean age=31.3 years, SD=11.6, Assessment group: mean age=34.7 years, SD=11.5 |
Detail Info
| Sample Diagnosis |
DSM-IV |
| Related Diagnostic Tools |
Childhood Trauma Questionnaire (CTQ), PTSD Symptom Scale-Interview Version (PSS-I), Posttraumatic Diagnostic Scale (PDS), |
| Sample Status |
None |
| Controls Exposed |
NA |
| Replication Size |
None |
| Result Summary |
A gene x intervention x time effect was detected for individual polymorphisms, in particular the PACAP receptor, ADCYAP1R1. Subjects who did not receive treatment had higher symptoms than those who received intervention. Furthermore, subjects with the "risk" genotypes who did not receive intervention had higher PTSD symptoms compared to those with the "low risk" or "resilience" genotypes or those who received intervention. |
| Potential Biomarker |
None |
Genetic result reported by this study
Normal genetic result reported by this study (count: 2)
| Marker |
Phenotype |
Related Gene |
Statistical Values |
Author Comments |
Marker's Category |
|
rs2267735
|
PTSD symptoms at week 4 |
ADCYAP1R1 |
Intervention group: P-value=0.22, Assessment group: P-value=0.32 |
There were no significant differences at the 4-week time poi......
There were no significant differences at the 4-week time point for the intervention and the assessment groups.
More...
|
Non-significant |
|
rs2267735
|
Diagnosis of PTSD at week 12 |
ADCYAP1R1 |
Intervention group: X2= 5.85, P-value=0.02, Assessment group: X2= 0.04, P-value=0.84 |
Subjects with the risk genotype (CC) were more likely to be ......
Subjects with the risk genotype (CC) were more likely to be diagnosed with PTSD at week 12 (87.5%) compared to carriers of the low-risk allele (12.5%) if they were assessed-only, whereas there was no difference between genotype risk groups in the intervention cohort.
More...
|
Significant |
