SNP Report

Basic Info

Name	rs1541518 dbSNP Ensembl
Location	7:31108665 - 31108665(+)
Variant Seq	T
Ancestral Allele	T
Ref Seq	G
Minor Allele Frequence	0.399161
Annotation	downstream_gene_variant; 3_prime_UTR_variant
Variant Effect	downstream_gene_variant(ENST00000409363, ENST00000409489, ENST00000396211, ENST00000436116); 3_prime_UTR_variant(ENST00000614107, ENST00000304166)
SIFT Annotation	deleterious
SIFT Variant Effect	deleterious(ENST00000436116, ENST00000614107, ENST00000304166, ENST00000409489, ENST00000396211, ENST00000409363)
PolyPhen Annotation	probably_damaging; possibly_damaging
PolyPhen Variant Effect	probably_damaging(ENST00000409489); possibly_damaging(ENST00000436116, ENST00000614107, ENST00000304166, ENST00000396211, ENST00000409363)
rSNP?	Yes Link in rVarBase
Related Regulatory Elements	lncRNA
Chromatin State	Weak transcription;Strong transcription;Enhancers
No. of Marker's Association Results	1 (Positive: 0; Negative: 1; Trend: 0)
Source	Literature

SNP related association results

Normal genetic study related association results (count: 1)

Reference	Phenotype	Statistical Values	Author Comments	Marker's Category
Ressler, K. J.,2011	PTSD diagnosis	Females: P-value=0.064, males: P-value=0.974 Females: P-value=0.064, males: P-value=0.974	No significant result in females or males after multiple cor...... No significant result in females or males after multiple corrections. More...	Non-significant

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Association Results (Positive/Negative/Trend)
ADCYAP1R1	adenylate cyclase activating polypeptide 1 (pituitary) receptor type I	7p14.3	19(8/11/0)

SNPs in LD with rs1541518 (count: 6)

The LD data used here is based on 1000 Genome Phase I. LD SNP pairs were selected with a threshold r²<=0.8.


rs_ID	Annotation	No. of Association Results(Positive/Negative/Trend)	r²[population]
rs2284225	intron_variant(ENST00000436116, ENST00000614107, ENST00000409363, ENST00000409489, ENST00000304166, ENST00000396211)	1(0/1/0)	0.8757[AFR]

rs_ID	Literature-origin SNPs with LD	Annotation	r²[population]
rs4723047	rs2284225 rs1541518	intron_variant	0.8360[AFR]
rs4723046	rs2284225 rs1541518	intron_variant	0.8360[AFR]
rs7793414	rs1541518	downstream_gene_variant; 3_prime_UTR_variant	1.0000[AFR]
rs7786849	rs1541518	upstream_gene_variant	0.8382[AFR]
rs4472421	rs1541518	upstream_gene_variant	0.8947[AFR]

SNP related eQTL (count: 1)

Gene Symbol	Gene Existed in PTSDgene?	Tissue	Trans/Cis	Source
LRRC37A4P	No	Adipose Subcutaneous	cis	GTEx