PTSDgene database

Study Report

Study Information
Basic Info
Reference
Citation Wang, L., et al. (2013). "PAC1 receptor (ADCYAP1R1) genotype is associated with PTSD's emotional numbing symptoms in Chinese earthquake survivors." J Affect Disord 150(1): 156-159.
Phenotype PTSD symptoms, Reexperiencing symptoms, Avoidance symptoms, Emotional numbing symptoms, Dsyphoric arousal symptoms, Anxious arousal symptoms
Trauma Lost their children during the 2008 Wenchuan earthquake.
Study Design Cross-sectional study
Study Type Candidate gene association study
Sample Size 319 samples
SNP/Marker Size 1 SNP
Predominant Ethnicity Mongloid
Population Chinese
Gender 94 males, 225 females
Age Mean age=44.9 years, SD= 11.6

Detail Info

Genetic result reported by this study
Normal genetic result reported by this study (count: 6)
Marker Phenotype Related Gene Statistical Values Author Comments Marker's Category
rs2267735 Avoidance symptoms ADCYAP1R1 CC carriers vs G allele carriers: In women: B=0.02, P-value=0.73, In men: B=0.02, P-value=0.84 No association was found. No association was found. Non-significant
rs2267735 Anxious arousal symptoms ADCYAP1R1 CC carriers vs G allele carriers: In women: B=0.06, P-value=0.39, In men: B=0.18, P-value=0.08 No association was found. No association was found. Non-significant
rs2267735 Emotional numbing symptoms ADCYAP1R1 CC carriers vs G allele carriers: In women: B=0.17, P-value=0.01, In men: B=0.05, P-value=0.63 Only emotional numbing symptoms were associated with rs22677...... Only emotional numbing symptoms were associated with rs2267735 in women, but not men. The rs2267735 'CC' genotpe also was associated with only emotional numbing symptoms in women after controlling for demographic variables. More... Significant
rs2267735 Dysphoric arousal symptoms ADCYAP1R1 CC carriers vs G allele carriers: In women: B=0.03, P-value=0.63, In men: B=-0.10, P-value=0.32 No association was found. No association was found. Non-significant
rs2267735 PTSD symptoms ADCYAP1R1 CC carriers vs G allele carriers: In women: B=0.12, P-value=0.08, In men: B<0.01, P-value=0.98 The rs2267735 'cc' genotype was not associated with total PT...... The rs2267735 'cc' genotype was not associated with total PTSD symptoms, the association in women was marginally significant. More... Non-significant
rs2267735 Reexperiencing symptoms ADCYAP1R1 CC carriers vs G allele carriers: In women: B=0.11, P-value=0.09, In men: B=-0.07, P-value=0.52 No association was found. No association was found. Non-significant