Study Report
Study Information
Basic Info
| Reference |
Wang, L.,2013 PMID: 23394710
|
| Citation |
Wang, L., et al. (2013). "PAC1 receptor (ADCYAP1R1) genotype is associated with PTSD's emotional numbing symptoms in Chinese earthquake survivors." J Affect Disord 150(1): 156-159. |
| Phenotype |
PTSD symptoms, Reexperiencing symptoms, Avoidance symptoms, Emotional numbing symptoms, Dsyphoric arousal symptoms, Anxious arousal symptoms |
| Trauma |
Lost their children during the 2008 Wenchuan earthquake. |
| Study Design |
Cross-sectional study |
| Study Type |
Candidate gene association study |
| Sample Size |
319 samples |
| SNP/Marker Size |
1 SNP |
| Predominant Ethnicity |
Mongloid |
| Population |
Chinese |
| Gender |
94 males, 225 females |
| Age |
Mean age=44.9 years, SD= 11.6 |
Detail Info
| Sample Diagnosis |
DSM-IV |
| Related Diagnostic Tools |
PTSD Checklist (PCL) |
| Sample Status |
All perticipants personally experienced the earthquake. |
| Controls Exposed |
NA |
| Replication Size |
None |
| Result Summary |
The results indicated that although the rs2267735 'cc' genotype was not associated with total PTSD symptoms, it could significantly predict severity of PTSD's emotional numbing symptoms in women. The findings suggest that the PACAP-PAC1 receptor pathway may play an important role in female human responses to tramatic stress. |
| Potential Biomarker |
None |
Genetic result reported by this study
Normal genetic result reported by this study (count: 6)
| Marker |
Phenotype |
Related Gene |
Statistical Values |
Author Comments |
Marker's Category |
|
rs2267735
|
Avoidance symptoms |
ADCYAP1R1 |
CC carriers vs G allele carriers: In women: B=0.02, P-value=0.73, In men: B=0.02, P-value=0.84 |
No association was found.
No association was found.
|
Non-significant |
|
rs2267735
|
Anxious arousal symptoms |
ADCYAP1R1 |
CC carriers vs G allele carriers: In women: B=0.06, P-value=0.39, In men: B=0.18, P-value=0.08 |
No association was found.
No association was found.
|
Non-significant |
|
rs2267735
|
Emotional numbing symptoms |
ADCYAP1R1 |
CC carriers vs G allele carriers: In women: B=0.17, P-value=0.01, In men: B=0.05, P-value=0.63 |
Only emotional numbing symptoms were associated with rs22677......
Only emotional numbing symptoms were associated with rs2267735 in women, but not men. The rs2267735 'CC' genotpe also was associated with only emotional numbing symptoms in women after controlling for demographic variables.
More...
|
Significant |
|
rs2267735
|
Dysphoric arousal symptoms |
ADCYAP1R1 |
CC carriers vs G allele carriers: In women: B=0.03, P-value=0.63, In men: B=-0.10, P-value=0.32 |
No association was found.
No association was found.
|
Non-significant |
|
rs2267735
|
PTSD symptoms |
ADCYAP1R1 |
CC carriers vs G allele carriers: In women: B=0.12, P-value=0.08, In men: B<0.01, P-value=0.98 |
The rs2267735 'cc' genotype was not associated with total PT......
The rs2267735 'cc' genotype was not associated with total PTSD symptoms, the association in women was marginally significant.
More...
|
Non-significant |
|
rs2267735
|
Reexperiencing symptoms |
ADCYAP1R1 |
CC carriers vs G allele carriers: In women: B=0.11, P-value=0.09, In men: B=-0.07, P-value=0.52 |
No association was found.
No association was found.
|
Non-significant |
