PTSDgene database

Pathway Enrichment Analysis Protein-Protein Interaction Analysis

Study Report

Study Information

Basic Info

Reference	Amstadter, A. B.,2011 PMID: 21508513
Citation	Amstadter, A. B., et al. (2011). "Corticotrophin-releasing hormone type 1 receptor gene (CRHR1) variants predict posttraumatic stress disorder onset and course in pediatric injury patients." Dis Markers 30(2-3): 89-99.
Phenotype	Acute UCLA PTSD-RI score, Acute symptoms of PTSD, Decline in PTSD symptoms
Trauma	Injuries between April 2002 and January 2004
Study Design	Cohort study
Study Type	Candidate gene association study
Sample Size	103 samples
SNP/Marker Size	8 SNPs
Predominant Ethnicity	Caucasian
Population	42 Non-Hispanic White, 47 Non-Hispanic Black, 14 Other
Gender	76 males, 27 females
Age	7-8 years: 8; 9-10 years: 7; 11-12 years: 9; 13-14 years: 11; 15-16 years: 31; 17-18 years: 34

Detail Info

Genetic result reported by this study

Normal genetic result reported by this study (count: 10)

Marker	Phenotype	Related Gene	Statistical Values	Author Comments	Marker's Category
rs12936181	Acute UCLA PTSD-RI score	CRHR1	B=2.07, t=0.99, Empirical P-value=0.42	No significant result. No significant result.	Non-significant
rs12944712	Acute symptoms of PTSD	CRHR1	Latent growth analyses, z-statistic=3.35, P-value<0.001.	Having an increasing number of G alleles was significantly a...... Having an increasing number of G alleles was significantly associated with more acute symptoms of PTSD. More...	Significant
rs4458044	Acute UCLA PTSD-RI score	CRHR1	B=-1.53, t=-0.62, Empirical P-value=1.00	No significant result. No significant result.	Non-significant
rs2424942	Acute UCLA PTSD-RI score	CRHR1	B=-1.00, t=-0.40, Empirical P-value=0.78	No significant result. No significant result.	Non-significant
rs4074461	Acute UCLA PTSD-RI score	CRHR1	B=4.10, t=2.40, Empirical P-value=0.02	This SNP was significantly related to PTSD symptom frequency...... This SNP was significantly related to PTSD symptom frequency. More...	Significant
rs12944712	Decline in PTSD symptoms	CRHR1	Latent growth analyses, z-statistic=-3.74, P-value<0.001.	An increasing number of G alleles was associated with a sign...... An increasing number of G alleles was associated with a significantly greater decline in PTSD symptoms over time. More...	Significant
rs17763104	Acute UCLA PTSD-RI score	CRHR1	B=-6.66, t=-2.46, Empirical P-value=0.02	This SNP was significantly related to PTSD symptom frequency...... This SNP was significantly related to PTSD symptom frequency. More...	Significant
rs17763658	Acute UCLA PTSD-RI score	CRHR1	B=3.90, t=1.19, Empirical P-value=0.26	No significant result. No significant result.	Non-significant
rs12944712	Acute UCLA PTSD-RI score	CRHR1	B=-5.36, t=-2.94, Empirical P-value=0.005	This SNP was significantly related to PTSD symptom frequency...... This SNP was significantly related to PTSD symptom frequency. With Bonferroni correction, one of the eight SNPs (rs12944712) remained significantly associated with PTSD symptom frequency. More...	Significant
rs17690314	Acute UCLA PTSD-RI score	CRHR1	B=-5.41, t=-1.87, Empirical P-value=0.08	No significant result. No significant result.	Non-significant