PTSDgene database

SNP Report

Basic Info
Name rs17689966 dbSNP Ensembl
Location 17:45833089 - 45833089(+)
Variant Seq A
Ancestral Allele G
Ref Seq G
Minor Allele Frequence 0.360224
Annotation downstream_gene_variant; upstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_variant
Variant Effect downstream_gene_variant(ENST00000580955, ENST00000582766); upstream_gene_variant(ENST00000535778, ENST00000580876); intron_variant(ENST00000583888, ENST00000619154, ENST00000398285, ENST00000634540, ENST00000634876, ENST00000581479, ENST00000293493, ENST00000352855, ENST00000339069, ENST00000314537, ENST00000347197, ENST00000577353); NMD_transcript_variant(ENST00000583888, ENST00000347197); non_coding_transcript_variant(ENST00000634876, ENST00000581479)
SIFT Annotation deleterious_-_low_confidence; deleterious
SIFT Variant Effect deleterious_-_low_confidence(ENST00000535778); deleterious(ENST00000577353, ENST00000314537, ENST00000398285, ENST00000293493, ENST00000634540, ENST00000352855, ENST00000339069)
PolyPhen Annotation benign; probably_damaging
PolyPhen Variant Effect benign(ENST00000535778); probably_damaging(ENST00000577353, ENST00000314537, ENST00000398285, ENST00000293493, ENST00000634540, ENST00000352855, ENST00000339069)
rSNP? Yes Link in rVarBase
Related Regulatory Elements TF binding region
Chromatin State Weak transcription
No. of Marker's Association Results 1 (Positive: 1; Negative: 0; Trend: 0)
Source Literature

SNP related association results
Normal genetic study related association results (count: 1)
Reference Phenotype Statistical Values Author Comments Marker's Category
White, S.,2013 Post-hurricane PTSD symptoms In EA sunsamples: B=0.76, t=1.98, P-value=0.049 In EA sunsamples: B=0.76, t=1.98, P-value=0.049 Nominally associated with higher post-hurricane PTSD symptom...... Nominally associated with higher post-hurricane PTSD symptoms More... Significant


SNP related genes (count: 2)
Approved Symbol Approved Name Location No. of Association Results (Positive/Negative/Trend)
CRHR1 corticotropin releasing hormone receptor 1 17q21.31 12(6/6/0)
MAPT-AS1 MAPT antisense RNA 1 17q21.31 Mapped by Literature SNP, Mapped by LD-proxy, rSNP target

SNPs in LD with rs17689966 (count: 6)
The LD data used here is based on 1000 Genome Phase I. LD SNP pairs were selected with a threshold r2<=0.8.

Literature-origin SNPs (count: 1)

LD-proxies (count: 5)


SNP related eQTL (count: 1)
Gene Symbol Gene Existed in PTSDgene? Tissue Trans/Cis Source
DND1P1 No Adipose Subcutaneous cis GTEx