PTSDgene database

SNP Report

Basic Info
Name rs4792887 dbSNP Ensembl
Location 17:45799654 - 45799654(+)
Variant Seq T
Ancestral Allele C
Ref Seq C
Minor Allele Frequence 0.129992
Annotation non_coding_transcript_exon_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_variant
Variant Effect non_coding_transcript_exon_variant(ENST00000634876); intron_variant(ENST00000634540, ENST00000577353, ENST00000398285, ENST00000293493, ENST00000347197, ENST00000587305, ENST00000339069, ENST00000582766, ENST00000352855, ENST00000314537, ENST00000619154); NMD_transcript_variant(ENST00000347197); non_coding_transcript_variant(ENST00000587305, ENST00000634876, ENST00000582766)
SIFT Annotation deleterious; tolerated
SIFT Variant Effect deleterious(ENST00000430334); tolerated(ENST00000430334, ENST00000581448, ENST00000584420, ENST00000589780)
PolyPhen Annotation benign; possibly_damaging
PolyPhen Variant Effect benign(ENST00000430334, ENST00000581448, ENST00000584420, ENST00000589780); possibly_damaging(ENST00000430334, ENST00000584420)
rSNP? Yes Link in rVarBase
Related Regulatory Elements n/a
Chromatin State Weak transcription
No. of Marker's Association Results 2 (Positive: 1; Negative: 1; Trend: 0)
Source Literature

SNP related association results
Normal genetic study related association results (count: 2)
Reference Phenotype Statistical Values Author Comments Marker's Category
White, S.,2013 Post-hurricane PTSD diagnosis OR=0.18, P-value=.007 OR=0.18, P-value=.007 Rs4792887 was not significantly related to diagnostic status Rs4792887 was not significantly related to diagnostic status Non-significant
White, S.,2013 Post-hurricane PTSD symptoms In EA sunsamples: B=-0.31, t=-3.22, P-value=0.001 In EA sunsamples: B=-0.31, t=-3.22, P-value=0.001 Nominally associated with higher post-hurricane PTSD symptom...... Nominally associated with higher post-hurricane PTSD symptoms, after a Bonferroni adjustment for multiple testing was employed, remained significant. More... Significant

SNP related genes (count: 2)
Approved Symbol Approved Name Location No. of Association Results (Positive/Negative/Trend)
CRHR1 corticotropin releasing hormone receptor 1 17q21.31 12(6/6/0)
MAPT-AS1 MAPT antisense RNA 1 17q21.31 Mapped by Literature SNP, Mapped by LD-proxy, rSNP target

SNPs in LD with rs4792887 (count: 14)
The LD data used here is based on 1000 Genome Phase I. LD SNP pairs were selected with a threshold r2<=0.8.

Literature-origin SNPs (count: 1)

LD-proxies (count: 13)

SNP related eQTL (count: 1)
Gene Symbol Gene Existed in PTSDgene? Tissue Trans/Cis Source
DND1P1 No Adipose Subcutaneous cis GTEx