SNP Report

Basic Info

Name	rs4074461 dbSNP Ensembl
Location	17:45777790 - 45777790(+)
Variant Seq	T
Ancestral Allele	T
Ref Seq	G
Minor Allele Frequence	0.372204
Annotation	intron_variant; non_coding_transcript_variant
Variant Effect	intron_variant(ENST00000634540, ENST00000587305); non_coding_transcript_variant(ENST00000587305)
SIFT Annotation	deleterious; tolerated
SIFT Variant Effect	deleterious(ENST00000430334); tolerated(ENST00000430334, ENST00000581448, ENST00000584420, ENST00000589780)
PolyPhen Annotation	benign; possibly_damaging
PolyPhen Variant Effect	benign(ENST00000430334, ENST00000581448, ENST00000584420, ENST00000589780); possibly_damaging(ENST00000430334, ENST00000584420)
rSNP?	Yes Link in rVarBase
Related Regulatory Elements	n/a
Chromatin State	Weak transcription
No. of Marker's Association Results	1 (Positive: 1; Negative: 0; Trend: 0)
Source	Literature

SNP related association results

Normal genetic study related association results (count: 1)

Reference	Phenotype	Statistical Values	Author Comments	Marker's Category
Amstadter, A. B.,2011	Acute UCLA PTSD-RI score	B=4.10, t=2.40, Empirical P-value=0.02 B=4.10, t=2.40, Empirical P-value=0.02	This SNP was significantly related to PTSD symptom frequency...... This SNP was significantly related to PTSD symptom frequency. More...	Significant

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Association Results (Positive/Negative/Trend)
CRHR1	corticotropin releasing hormone receptor 1	17q21.31	12(6/6/0)

SNPs in LD with rs4074461 (count: 9)

The LD data used here is based on 1000 Genome Phase I. LD SNP pairs were selected with a threshold r²<=0.8.

rs_ID	Annotation	No. of Association Results(Positive/Negative/Trend)	r²[population]

rs7209436	intron_variant(ENST00000293493, ENST00000619154, ENST00000314537, ENST00000398285, ENST00000352855, ENST00000582766, ENST00000587305, ENST00000634540, ENST00000347197, ENST00000577353, ENST00000339069); NMD_transcript_variant(ENST00000347197); non_coding_transcript_variant(ENST00000582766, ENST00000587305)	2(0/2/0)	0.8053[EUR]
rs110402	upstream_gene_variant(ENST00000580955); intron_variant(ENST00000352855, ENST00000619154, ENST00000582766, ENST00000634876, ENST00000587305, ENST00000634540, ENST00000398285, ENST00000314537, ENST00000347197, ENST00000577353, ENST00000293493, ENST00000339069); NMD_transcript_variant(ENST00000347197); non_coding_transcript_variant(ENST00000582766, ENST00000634876, ENST00000587305)	2(0/2/0)	0.8590[EUR]
rs242924	intron_variant(ENST00000577353, ENST00000339069, ENST00000398285, ENST00000582766, ENST00000634876, ENST00000352855, ENST00000634540, ENST00000619154, ENST00000580955, ENST00000587305, ENST00000347197, ENST00000293493, ENST00000314537); NMD_transcript_variant(ENST00000580955, ENST00000347197); non_coding_transcript_variant(ENST00000582766, ENST00000634876, ENST00000587305)	2(0/2/0)	0.8345[EUR]

rs_ID	Literature-origin SNPs with LD	Annotation	r²[population]
rs12952301	rs4074461 rs7209436 rs242924 rs110402	intron_variant; non_coding_transcript_variant	0.9947[EUR]
rs12950522	rs4074461 rs7209436 rs242924 rs110402	upstream_gene_variant; intron_variant; non_coding_transcript_variant	0.9686[EUR]
rs4792880	rs4074461	intron_variant; non_coding_transcript_variant	0.8697[EUR]
rs35909029	rs4074461	intron_variant; non_coding_transcript_variant	0.8207[EUR]
rs6503448	rs4074461	intron_variant; non_coding_transcript_variant	0.8603[EUR]
rs6503450	rs4074461	intron_variant; non_coding_transcript_variant	0.8983[EUR]

SNP related eQTL (count: 1)

Gene Symbol	Gene Existed in PTSDgene?	Tissue	Trans/Cis	Source
DND1P1	No	Adipose Subcutaneous	cis	GTEx